Proteintech

Kir4.1 Polyclonal Antibody

Kir4.1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

Kir4.1 Antibody (12503-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 12503-1-AP ( Kir4.1 antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Kir4.1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12503-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Kir4.1 Fusion Protein Ag3182 (224-426 aa encoded by BC034036)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ETIRFSQHA VVASHNGKPC LMIRVANMRK SLLIGCQVTG KLLQTHQTKE GENIRLNQVN VTFQVDTASD SPFLILPLTF YHVVDETSPL KDLPLRSGEG DFELVLILSG TVESTSATCQ VRTSYLPEEI LWGYEFTPAI SLSASGKYIA DFSLFDQVVK VASPSGLRDS TVRYGDPEKL KLEESLREQA EKEGSALSVR ISNV (224-426 aa encoded by B C034036)

Target Information

The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation.

Neuron

Curry RN,Aiba I,Meyer J,Lozzi B,Ko Y,McDonald MF,Rosenbaum A,Cervantes A,Huang-Hobbs E,Cocito C,Greenfield JP,Jalali A,Gavvala J,Mohila C,Serin Harmanci A,Noebels J,Rao G,Deneen B

Wed Mar 01 00:00:00 EST 2023

A novel model of subretinal edema induced by DL-alpha aminoadipic acid.

Experimental eye research

Xie Z,Wu X,Cheng R,Huang J,Wang X,Shi Q,Xu B,Paulus YM,Yuan S,Liu Q

Wed Mar 01 00:00:00 EST 2023

Low reliability of anti-KIR4.1_83-120 peptide auto-antibodies in multiple sclerosis patients.

Multiple sclerosis (Houndmills, Basingstoke, England)

Marino M,Frisullo G,Di Sante G,Samengo DM,Provenzano C,Mirabella M,Pani G,Ria F,Bartoccioni E

Fri Jun 01 00:00:00 EDT 2018

Low reliability of anti-KIR4.1_83-120 peptide auto-antibodies in multiple sclerosis patients.

Multiple sclerosis (Houndmills, Basingstoke, England)

Marino M,Frisullo G,Di Sante G,Samengo DM,Provenzano C,Mirabella M,Pani G,Ria F,Bartoccioni E

Fri Jun 01 00:00:00 EDT 2018

Wnt/β-catenin signaling mediates the seizure-facilitating effect of postischemic reactive astrocytes after pentylenetetrazole-kindling.

Glia

Yang J,Zhang X,Wu Y,Zhao B,Liu X,Pan Y,Liu Y,Ding Y,Qiu M,Wang YZ,Zhao G

Wed Jun 01 00:00:00 EDT 2016

Wnt/β-catenin signaling mediates the seizure-facilitating effect of postischemic reactive astrocytes after pentylenetetrazole-kindling.

Glia

Yang J,Zhang X,Wu Y,Zhao B,Liu X,Pan Y,Liu Y,Ding Y,Qiu M,Wang YZ,Zhao G

Wed Jun 01 00:00:00 EDT 2016

Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease.

Glia

Minkel HR,Anwer TZ,Arps KM,Brenner M,Olsen ML

Tue Dec 01 00:00:00 EST 2015

Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease.

Glia

Minkel HR,Anwer TZ,Arps KM,Brenner M,Olsen ML

Tue Dec 01 00:00:00 EST 2015

Bioinformatics

Protein Aliases: ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; BIRK10; Brain-specific inwardly rectifying K(+) channel 1; glial ATP-dependent inwardly rectifying potassium channel KIR4.1; Inward rectifier K(+) channel Kir1.2; Inward rectifier K(+) channel Kir4.1; inward rectifier K+ channel KIR1.2; KCNJ13 PEN; kir4.1; Potassium channel, inwardly rectifying subfamily J member 10; potassium channel, inwardly rectifying subfamily J, member 10; potassium inwardly-rectifying channel, subfamily J, member 10

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Gene Aliases: BIR10; BIRK-1; BIRK-10; Kab-2; KCNJ10; KCNJ13-PEN; KIR1.2; KIR4.1; SESAME

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UniProt ID: (Human) P78508, (Rat) P49655, (Mouse) Q9JM63

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Entrez Gene ID: (Human) 3766, (Rat) 29718, (Mouse) 16513

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Function(s)

inward rectifier potassium channel activity protein binding ATP binding ATP-activated inward rectifier potassium channel activity G-protein activated inward rectifier potassium channel activity receptor binding potassium channel activity identical protein binding nucleotide binding voltage-gated ion channel activity ion channel transporter

Process(es)

potassium ion transport visual perception adult walking behavior potassium ion import central nervous system myelination regulation of ion transmembrane transport regulation of long-term neuronal synaptic plasticity glutamate reuptake potassium ion homeostasis regulation of resting membrane potential inflammatory response response to blue light oligodendrocyte development optic nerve development regulation of membrane potential protein homotetramerization response to glucocorticoid response to mineralocorticoid regulation of sensory perception of pain L-glutamate import membrane hyperpolarization potassium ion transmembrane transport transport ion transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Kir4.1 Polyclonal Antibody

Kir4.1 Antibody (12503-1-AP) in IHC (P)

Product Details

12503-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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