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Product Details
MA1-40129
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Goat,
Human,
Non-human primate,
Sheep,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6G3
Immunogen
Human natural and recombinant LBP.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2138321
Product Specific Information
MA1-40129 detects LBP from human, bovine, dog, goat, cynomologous monkey, rabbit, rat, sheep, and swine samples. Does not react with mouse or equine samples.
MA1-40129 has been successfully used in immunoprecipitation, functional assays and ELISA applications. Not useful in Immunohistochemistry or Western blot applications. ELISA: monoclonal antibody 3F9 can be used both as coating and as detector.
The MA1-40129 immunogen is human natural and recombinant LBP.
Endotoxin <24 EU/mg.
Target Information
The LBP protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acute phase protein; binds bacterial LPS; BPI fold containing family D, member 2; LBP; Lipopolysaccharide-binding protein; LPS-binding protein
Gene Aliases: BPIFD2; LBP; LPSBP
UniProt ID: (Bovine) Q2TBI0, (Human) P18428
Entrez Gene ID: (Bovine) 512242, (Pig) 397303, (Rabbit) 100009124, (Human) 3929, (Goat) 102186029, (Dog) 485869, (Sheep) 101104595, (Rat) 29469
macrophage activation involved in immune response
lipid transport
acute-phase response
positive regulation of tumor necrosis factor production
innate immune response
defense response to Gram-negative bacterium
cellular response to lipopolysaccharide
liver development
leukocyte chemotaxis involved in inflammatory response
cellular defense response
opsonization
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
detection of molecule of bacterial origin
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of macrophage activation
negative regulation of growth of symbiont in host
defense response to Gram-positive bacterium
positive regulation of phagocytosis, engulfment
positive regulation of respiratory burst involved in inflammatory response
cellular response to lipoteichoic acid
positive regulation of neutrophil chemotaxis
regulation of membrane permeability
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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