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Product Details
CF500796
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3H1
Immunogen
Full length human recombinant protein of human LEMD3 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inner nuclear membrane protein Man1; integral inner nuclear membrane protein; LEM domain-containing protein 3
Gene Aliases: LEMD3; MAN1; RGD1561001
UniProt ID: (Human) Q9Y2U8
Entrez Gene ID: (Dog) 608380, (Human) 23592, (Rat) 680066
angiogenesis
blood vessel endothelial cell migration involved in intussusceptive angiogenesis
nucleus organization
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
negative regulation of activin receptor signaling pathway
skeletal muscle cell differentiation
regulation of cell cycle
regulation of extracellular matrix organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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