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LETMD1 Antibody (PA5-96069) in IHC (P)
Immunohistochemistry analysis of LETMD1 in paraffin-embedded mouse kidney. Samples were incubated with LETMD1 Polyclonal antibody (Product # PA5-96069) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96069
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 161-360 of human LETMD1 (NP_0562313)
Conjugate
Form
Liquid
Concentration
1.29 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2807871
Product Specific Information
Immunogen sequence: FPRQLLIRHF WTPKQQTDFL DIYHAFRKQS HPEIISYLEK VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS NHPLGMNQLQ ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL LSTNYLGTRR; Positive Samples: MCF7, Mouse liver; Cellular Location: Mitochondrion outer membrane, Single-pass membrane protein
Target Information
HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360 amino acid single-pass membrane protein that is expressed in the kidney, liver, skeletal muscle, heart and brain. It is suggested that HCCR-1 may be involved in tumorigenesis and may function as a negative regulator of the p53 tumor suppressor. Overexpression of HCCR-1 may cause mitochondrial dysfunction that can lead to UVC or staurosporine-induced apoptosis resistance and progression of tumor formation. HCCR-1 is considered a candidate biomarker for breast cancer. Various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix have high HCCR-1. Six isoforms exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cervical cancer 1 proto-oncogene protein p40; Cervical cancer proto-oncogene 2 protein; Cervical cancer receptor; HCCR-1; HCRR-2; LETM1 domain-containing protein 1; MCC-32; regulator of TP53
Gene Aliases: 1110019O13Rik; AI593524; BB130465; BB235638; HCCR-1; HCCR-2; HCCR1; HCRR-2; LETMD1; MCC-32; Mccr; RGD1310591
UniProt ID: (Human) Q6P1Q0, (Mouse) Q924L1
Entrez Gene ID: (Human) 25875, (Mouse) 68614, (Rat) 681352
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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