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Product Details
PA5-76197
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human LHCGR.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2719924
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
LHCGR encodes the receptor for both luteinizing hormone and choriogonadotropin. It is family 1 of G-protein coupled receptors, FSH/LSH/TSH superfamily, and its basic function is acting as luteinizing hormone/choriogonadotropin receptor (gonadotropin receptor). Regulating the development and function of Leyding cells in males. It also plays a role in male secondary sexual characterdevelopment. Mutations in this gonadotropinreceptor results in disorders of male secondary sexual characteristic development, such as familial male precocious puperty and male pseudohermaphtoditism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HCG receptor; hypergonadotropic hypogonadism; LH receptor; LH/CG-R; LHR; LSH-R; Luteinizing hormone receptor; Lutropin receptor; Lutropin-choriogonadotropic hormone receptor; lutropin/choriogonadotropin receptor
Gene Aliases: Gpcr19-rs1; HHG; LCGR; LGR2; LH-R; LH/CG-R; LH/CGR; LHCGR; LHR; LHRHR; LSH-R; LSHR; ULG5
UniProt ID: (Human) P22888, (Rat) P16235, (Mouse) P30730
Entrez Gene ID: (Human) 3973, (Rat) 25477, (Mouse) 16867
luteinizing hormone receptor activity
G-protein coupled peptide receptor activity
choriogonadotropin hormone receptor activity
choriogonadotropin hormone binding
peptide hormone binding
identical protein binding
protein homodimerization activity
ATPase binding
signal transducer activity
G-protein coupled receptor activity
protein-hormone receptor activity
G-protein coupled receptor
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
male gonad development
hormone-mediated signaling pathway
ovulation cycle process
male genitalia development
positive regulation of inositol trisphosphate biosynthetic process
luteinizing hormone signaling pathway
positive regulation of cAMP-mediated signaling
cognition
cellular response to gonadotropin stimulus
ovarian follicle development
protein targeting to lysosome
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
spermatogenesis
central nervous system development
female gonad development
positive regulation of calcium ion transport into cytosol
response to drug
development of secondary male sexual characteristics
positive regulation of hormone biosynthetic process
arachidonic acid secretion
regulation of steroid biosynthetic process
positive regulation of calcium-mediated signaling
positive regulation of release of sequestered calcium ion into cytosol
uterus development
seminiferous tubule development
regulation of steroid hormone biosynthetic process
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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