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Product Details
PA5-109910
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 254-460 of human DNA Ligase III/LIG3 (NP_0392692)
Conjugate
Form
Liquid
Concentration
0.75 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855321
Product Specific Information
Immunogen sequence: CDPRHKDCLL REFRKLCAMV ADNPSYNTKT QIIQDFLRKG SAGDGFHGDV YLTVKLLLPG VIKTVYNLND KQIVKLFSRI FNCNPDDMAR DLEQGDVSET IRVFFEQSKS FPPAAKSLLT IQEVDEFLLR LSKLTKEDEQ QQALQDIASR CTANDLKCII RLIKHDLKMN SGAKHVLDAL DPNAYEAFKA SRNLQDVVER VLHNAQE
Target Information
There are four distinct ligase proteins found in mammalian cells. The activity of these DNA ligases is required for the joining of DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase III gene product migrates as a 100 kDa (a-form) protein in somatic tissues, is ubiquitously expressed and complexes with XRCC-1 and a 97 kDa (beta form) protein that is found in testis. DNA Ligase III is involved in rejoining DNA single-strand breaks and in the base excision repair pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA ligase (ATP) 3; DNA ligase 3; DNA ligase III; ligase II, DNA, ATP-dependent; ligase III, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP] 3
Gene Aliases: D11Wsu78e; LIG2; LIG3
UniProt ID: (Human) P49916
Entrez Gene ID: (Human) 3980, (Rat) 303369, (Mouse) 16882
double-strand break repair via homologous recombination
lagging strand elongation
transcription-coupled nucleotide-excision repair
base-excision repair, DNA ligation
nucleotide-excision repair, DNA gap filling
double-strand break repair
cell cycle
V(D)J recombination
cell division
DNA biosynthetic process
negative regulation of mitochondrial DNA replication
DNA ligation
nucleotide-excision repair
double-strand break repair via nonhomologous end joining
DNA recombination
mitochondrion organization
mitochondrial DNA repair
negative regulation of DNA recombination
double-strand break repair via alternative nonhomologous end joining
DNA replication
DNA repair
cellular response to DNA damage stimulus
DNA ligation involved in DNA repair
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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