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Product Details
OSL00018W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from n-terminal region of human LIN7 (A, B, C) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: LIN7A, B, C.
Target Information
LIN7A Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hLin7B; hVeli2; lin 7 homolog a; lin 7 homolog b; lin 7 homolog C; lin-7 homolog B; lin-7 homolog C; LIN-7 protein 3; lin-7-A; lin-7-Ba; lin-7-C; Lin-7A; Lin-7B; Lin-7C; MALS-1; MALS-2; MALS-3; mammalian LIN-7 1; Mammalian lin-seven protein 1; Mammalian lin-seven protein 2; Mammalian lin-seven protein 3; mLin-7; mLin7C; Protein lin-7 homolog A; Protein lin-7 homolog B; Protein lin-7 homolog C; Tax interaction protein 33; TIP-33; Veli-1; veli-1 protein; Veli-2; veli-2 protein; Veli-3; veli-3 protein; vertebrate homolog of C. elegans Lin-7 type 1; vertebrate homolog of C. elegans Lin-7 type 2; vertebrate homolog of C. elegans Lin-7 type 3; Vertebrate lin-7 homolog 1; Vertebrate lin-7 homolog 2; Vertebrate lin-7 homolog 3; vertebrate LIN7 homolog 1
Gene Aliases: 9130007B12Rik; AI303698; AI848705; AU019331; AW125731; D2Ertd520e; LIN-7-C; LIN-7A; LIN-7B; LIN-7C; LIN7; LIN7A; LIN7B; LIN7C; MALS-1; MALS-2; MALS-3; MALS1; MALS2; MALS3; TIP-33; UNQ3116/PRO10200; Veli; VELI1; Veli1a; VELI2; VELI3
UniProt ID: (Human) O14910, (Human) Q9HAP6, (Human) Q9NUP9, (Mouse) Q8JZS0, (Rat) Q9Z252, (Mouse) O88951, (Rat) Q792I0, (Mouse) O88952
Entrez Gene ID: (Human) 8825, (Human) 64130, (Human) 55327, (Mouse) 108030, (Rat) 85327, (Rat) 60377, (Mouse) 22342, (Rat) 60442, (Mouse) 22343
protein complex assembly
exocytosis
neurotransmitter secretion
protein transport
maintenance of epithelial cell apical/basal polarity
synaptic vesicle transport
inner ear development
protein localization to basolateral plasma membrane
morphogenesis of an epithelial sheet
transport
asymmetric protein localization
cell-cell junction assembly
Performance Guarantee
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