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Product Details
19097-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LINGO1 Fusion Protein Ag13553 (36-351 aa encoded by BC011057)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SGSATGCPP RCECSAQDRA VLCHRKRFVA VPEGIPTETR LLDLGKNRIK TLNQDEFASF PHLEELELNE NIVSAVEPGA FNNLFNLRTL GLRSNRLKLI PLGVFTGLSN LTKLDISENK IVILLDYMFQ DLYNLKSLEV GDNDLVYISH RAFSGLNSLE QLTLEKCNLT SIPTEALSHL HGLIVLRLRH LNINAIRDYS FKRLYRLKVL EISHWPYLDT MTPNCLYGLN LTSLSITHCN LTAVPYLAVR HLVYLRFLNL SYNPISTIEG SMLHELLRLQ EIQLVGGQLA VVEPYAFRGL NYLRVLNVSG NQLTTLE (36-351 aa encoded by BC011057)
Target Information
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: leucine rich repeat neuronal 6A; leucine-rich repeat; Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine-rich repeat neuronal 6A; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
Gene Aliases: 4930471K13Rik; AV148400; LERN1; LINGO-1; LINGO1; LRRN6A; UNQ201; UNQ201/PRO227
UniProt ID: (Human) Q96FE5, (Mouse) Q9D1T0
Entrez Gene ID: (Human) 84894, (Rat) 315691, (Mouse) 235402
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