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Product Details
PA5-103211
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LAMB2(Accession P55268), corresponding to amino acid residues G72-A122.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852578
Product Specific Information
Antibody detects endogenous levels of total LAMB2.
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Laminin B1s chain; Laminin chain B3; laminin chain beta 2; Laminin S; Laminin subunit beta-2; laminin, beta 2 (laminin S); Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-LAM beta; S-laminin subunit beta
Gene Aliases: AW211941; Lamb-2; LAMB2; LAMS; NPHS5; npht; SLAM
UniProt ID: (Human) P55268, (Mouse) Q61292, (Rat) P15800
Entrez Gene ID: (Human) 3913, (Mouse) 16779, (Rat) 25473
cell adhesion
axon guidance
neuromuscular junction development
visual perception
astrocyte development
Schwann cell development
extracellular matrix organization
axon extension involved in regeneration
retina development in camera-type eye
metanephric glomerular visceral epithelial cell development
metanephric glomerular basement membrane development
cell morphogenesis involved in differentiation
neuron projection development
synapse organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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