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Invitrogen
Laminin gamma-1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 9
Laminin gamma-1 Antibody (PA5-90889) in IHC (P)
Immunohistochemistry analysis of Laminin gamma-1 in paraffin-embedded human breast cancer using. Samples were incubated with Laminin gamma-1 Polyclonal antibody (Product # PA5-90889) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-90889
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1275 of human LAMC1 (NP_0022843)
Conjugate
Form
Liquid
Concentration
1.82 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806276
Product Specific Information
Positive Samples: LO2, Mouse heart, Mouse kidney, Rat heart
Immunogen sequence: ECPACYRLVK DKVADHRVKL QELESLIANL GTGDEMVTDQ AFEDRLKEAE REVMDLLREA QDVKDVDQNL MDRLQRVNNT LSSQISRLQN IRNTIEETGN LAEQARAHVE NTERLIEIAS RELEKAKVAA ANVSVTQPES TGDPNNMTLL AEEARKLAER HKQEADDIVR VAKTANDTST EAYNLLLRTL AGENQTAFEI EELNRKYEQA KNISQDLEKQ AARVHEEAKR AGDKAVEIYA SVAQLS
Target Information
Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each Laminin is a heterotrimer of alpha, beta and gamma chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Laminin B2 chain; Laminin subunit gamma-1; laminin, gamma 1 (formerly LAMB2); Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; S-LAM gamma; S-laminin subunit gamma
Gene Aliases: B2e; LAMB2; LAMC1
UniProt ID: (Human) P11047
Entrez Gene ID: (Human) 3915, (Mouse) 226519, (Rat) 117036
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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