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Product Details
H00004117-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3E5
Immunogen
MAK (AAH39825, 358 a.a. approximately 457 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: PPKQQSQEKP PQTLFPSIVK NMPTKPNGTL SHKSGRRRWG QTIFKSGDSW EELEDYDFGA SHSKKPSMGV FKEKRKKDSP FRQQVKMAVI SLSAHQFPTL
Target Information
The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ417M14.2; Male germ cell-associated kinase; male germ cell-associated kinase retinal-enriched isoform; Protein kinase RCK; serine/threonine protein kinase MAK; Serine/threonine-protein kinase MAK; testicular secretory protein Li 28
Gene Aliases: A930010O05Rik; MAK; Rck; RP62
UniProt ID: (Human) P20794, (Mouse) Q04859, (Rat) P20793
Entrez Gene ID: (Human) 4117, (Mouse) 17152, (Rat) 25677
transcription coactivator activity
protein kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
nucleotide binding
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
multicellular organism development
spermatogenesis
cell differentiation
photoreceptor cell maintenance
protein autophosphorylation
regulation of cell cycle
phosphorylation
regulation of nucleic acid-templated transcription
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