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Product Details
17376-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MAPK11 Fusion Protein Ag11184 (1-364 aa encoded by BC027933)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSGPRAGFY RQELNKTVWE VPQRLQGLRP VGSGAYGSVC SAYDARLRQK VAVKKLSRPF QSLIHARRTY RELRLLKHLK HENVIGLLDV FTPATSIEDF SEVYLVTTLM GADLNNIVKC QALSDEHVQF LVYQLLRGLK YIHSAGIIHR DLKPSNVAVN EDCELRILDF GLARQADEEM TGYVATRWYR APEIMLNWMH YNQTVDIWSV GCIMAELLQG KALFPGSDYI DQLKRIMEVV GTPSPEVLAK ISSEHARTYI QSLPPMPQKD LSSIFRGANP LAIDLLGRML VLDSDQRVSA AEALAHAYFS QYHDPEDEPE AEPYDESVEA KERTLEEWKE LTYQEVLSFK PPEPPKPPGS LEIEQ (1-364 aa encoded by BC027933)
Target Information
MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP kinase 11; MAP kinase p38 beta; MAPK 11; mitogen activated protein kinase 11; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; OTTHUMP00000196655; p38-2; protein kinase, mitogen activated kinase, 11, p38beta; SAPK2b; Stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b
Gene Aliases: MAPK11; p38-2; P38B; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B
UniProt ID: (Human) Q15759, (Mouse) Q9WUI1
Entrez Gene ID: (Human) 5600, (Rat) 689314, (Mouse) 19094
MAPK cascade
activation of MAPK activity
transcription, DNA-templated
response to stress
signal transduction
Ras protein signal transduction
positive regulation of gene expression
intracellular signal transduction
positive regulation of erythrocyte differentiation
vascular endothelial growth factor receptor signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
positive regulation of muscle cell differentiation
negative regulation of cardiac muscle cell proliferation
cellular response to virus
regulation of signal transduction by p53 class mediator
positive regulation of interleukin-12 secretion
protein phosphorylation
regulation of cardiac muscle cell proliferation
regulation of transcription, DNA-templated
phosphorylation
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