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Product Details
PA5-101177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MAPKAPK3(Accession Q16644), corresponding to amino acid residues M299-V349.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850620
Product Specific Information
Antibody detects endogenous levels of total MAPK3.
Target Information
MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MAPKAPK3 was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3pK; Chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAPK-3; mitogen activated protein kinase-activated protein kinase 3; OTTHUMP00000210806; OTTHUMP00000210807
Gene Aliases: 3PK; AI874665; MAPKAP-K3; MAPKAP3; MAPKAPK-3; MAPKAPK3; MapkKapk3; MK-3; MK3
UniProt ID: (Human) Q16644, (Rat) Q66H84, (Mouse) Q3UMW7
Entrez Gene ID: (Human) 7867, (Rat) 315994, (Mouse) 102626
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
MAP kinase kinase activity
protein binding
calmodulin binding
ATP binding
calcium-dependent protein serine/threonine kinase activity
nucleotide binding
protein kinase activity
signal transducer activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase binding
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPK activity
toll-like receptor signaling pathway
response to stress
signal transduction
cell surface receptor signaling pathway
Ras protein signal transduction
peptidyl-serine phosphorylation
response to lipopolysaccharide
response to cytokine
macropinocytosis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
protein phosphorylation
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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