Proteintech

MARK2 Polyclonal Antibody

MARK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MARK2 Antibody (15492-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using (Product # 15492-1-AP) (MARK2 antibody) at dilution of 1:600 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

MARK2 Antibody in Immunoprecipitation (IP)

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Product Details

15492-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MARK2 Fusion Protein Ag7884 (10-372 aa encoded by BC008771)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LNERDTEQP TLGHLDSKPS SKSNMIRGRN SATSADEQPH IGNYRLLKTI GKGNFAKVKL ARHILTGKEV AVKIIDKTQL NSSSLQKLFR EVRIMKVLNH PNIVKLFEVI ETEKTLYLVM EYASGGEVFD YLVAHGRMKE KEARAKFRQI VSAVQYCHQK FIVHRDLKAE NLLLDADMNI KIADFGFSNE FTFGNKLDTF CGSPPYAAPE LFQGKKYDGP EVDVWSLGVI LYTLVSGSLP FDGQNLKELR ERVLRGKYRI PFYMSTDCEN LLKKFLILNP SKRGTLEQIM KDRWMNVGHE DDELKPYVEP LPDYKDPRRT ELMVSMGYTR EEIQDSLVGQ RYNEVMATYL LLGYKSSELE GDTI (10-372 aa encoded by BC008771)

Target Information

MARK2 is a serine/threonine protein kinase involved in the control of cell polarity and microtubule stability. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lanthanum Chloride Induces Axon Abnormality Through LKB1-MARK2 and LKB1-STK25-GM130 Signaling Pathways.

Cellular and molecular neurobiology

Song Z,Mao H,Liu J,Sun W,Wu S,Lu X,Jin C,Yang J

Sat Apr 01 00:00:00 EDT 2023

Molecular determinants of αVβ5 localization in flat clathrin lattices - role of αVβ5 in cell adhesion and proliferation.

Journal of cell science

Zuidema A,Wang W,Kreft M,Bleijerveld OB,Hoekman L,Aretz J,Böttcher RT,Fässler R,Sonnenberg A

Wed Jun 01 00:00:00 EDT 2022

MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.

Endocrinology

Tang EI,Cheng CY

Tue Oct 11 00:00:00 EDT 2022

MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.

Endocrinology

Tang EI,Cheng CY

Tue Oct 11 00:00:00 EDT 2022

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.

Nature communications

Chan TY,Egbert CM,Maxson JE,Siddiqui A,Larsen LJ,Kohler K,Balasooriya ER,Pennington KL,Tsang TM,Frey M,Soderblom EJ,Geng H,Müschen M,Forostyan TV,Free S,Mercenne G,Banks CJ,Valdoz J,Whatcott CJ,Foulks JM,Bearss DJ,O'Hare T,Huang DCS,Christensen KA,Moody J,Warner SL,Tyner JW,Andersen JL

Thu Sep 09 00:00:00 EDT 2021

The Non-hormonal Male Contraceptive Adjudin Exerts its Effects via MAPs and Signaling Proteins mTORC1/rpS6 and FAK-Y407.

Endocrinology

Wang L,Yan M,Li H,Wu S,Ge R,Wong CKC,Silvestrini B,Sun F,Cheng CY

Fri Jan 01 00:00:00 EST 2021

NC1-Peptide From Collagen α3 (IV) Chains in the Basement Membrane of Testes Regulates Spermatogenesis via p-FAK-Y407.

Endocrinology

Li H,Liu S,Wu S,Ge R,Cheng CY

Thu Oct 01 00:00:00 EDT 2020

CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization.

Endocrinology

Mao BP,Li L,Ge R,Li C,Wong CKC,Silvestrini B,Lian Q,Cheng CY

Sat Jun 01 00:00:00 EDT 2019

Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury.

Journal of neuroinflammation

DiBona VL,Zhu W,Shah MK,Rafalia A,Ben Cheikh H,Crockett DP,Zhang H

Thu Jan 17 00:00:00 EST 2019

Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury.

Journal of neuroinflammation

DiBona VL,Zhu W,Shah MK,Rafalia A,Ben Cheikh H,Crockett DP,Zhang H

Thu Jan 17 00:00:00 EST 2019

Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Gao Y,Mruk D,Chen H,Lui WY,Lee WM,Cheng CY

Wed Feb 01 00:00:00 EST 2017

Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Gao Y,Mruk D,Chen H,Lui WY,Lee WM,Cheng CY

Wed Feb 01 00:00:00 EST 2017

Basement Membrane Laminin α2 Regulation of BTB Dynamics via Its Effects on F-Actin and Microtubule Cytoskeletons Is Mediated Through mTORC1 Signaling.

Endocrinology

Gao Y,Chen H,Lui WY,Lee WM,Cheng CY

Sat Apr 01 00:00:00 EDT 2017

An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.

Molecular cell

Goodwin JM,Svensson RU,Lou HJ,Winslow MM,Turk BE,Shaw RJ

Thu Aug 07 00:00:00 EDT 2014

An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.

Molecular cell

Goodwin JM,Svensson RU,Lou HJ,Winslow MM,Turk BE,Shaw RJ

Thu Aug 07 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: ELKL motif kinase; ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; MARK2; mark2 {ECO:0000312|RGD:708483}; MGC99619; OTTHUMP00000218338; OTTHUMP00000218339; OTTHUMP00000218340; OTTHUMP00000218343; Par-1b; PAR1 homolog; PAR1 homolog b; Ser/Thr protein kinase PAR-1B; serine/threonine kinase; serine/threonine protein kinase EMK; Serine/threonine-protein kinase MARK2; testicular tissue protein Li 117

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Gene Aliases: Emk; EMK-1; EMK1; MARK2; PAR-1; Par-1b; Par1b

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UniProt ID: (Human) Q7KZI7, (Rat) O08679, (Mouse) Q05512

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Entrez Gene ID: (Human) 2011, (Rat) 60328, (Mouse) 13728

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Function(s)

magnesium ion binding protein serine/threonine kinase activity protein binding ATP binding lipid binding protein kinase activator activity poly(A) RNA binding tau-protein kinase activity cadherin binding involved in cell-cell adhesion nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding non-receptor serine/threonine protein kinase

Process(es)

microtubule cytoskeleton organization mitophagy neuron migration protein phosphorylation positive regulation of neuron projection development Wnt signaling pathway peptidyl-threonine phosphorylation establishment of cell polarity activation of protein kinase activity intracellular signal transduction establishment or maintenance of epithelial cell apical/basal polarity protein autophosphorylation regulation of axonogenesis regulation of cytoskeleton organization mitochondrion localization cell-cell adhesion multicellular organism development phosphorylation cell differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MARK2 Polyclonal Antibody

MARK2 Antibody (15492-1-AP) in IHC (P)

Product Details

15492-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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