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Product Details
H00002011-M01
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3B12
Immunogen
MARK2 (AAH08771, 401 a.a. approximately 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: QAAGPAIPTS NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST NRSRNSPLLE RASLGQASIQ NGKDSLTMPG
Target Information
MARK2 is a serine/threonine protein kinase involved in the control of cell polarity and microtubule stability. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ELKL motif kinase; ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; MARK2; mark2 {ECO:0000312|RGD:708483}; MGC99619; OTTHUMP00000218338; OTTHUMP00000218339; OTTHUMP00000218340; OTTHUMP00000218343; Par-1b; PAR1 homolog; PAR1 homolog b; Ser/Thr protein kinase PAR-1B; serine/threonine kinase; serine/threonine protein kinase EMK; Serine/threonine-protein kinase MARK2; testicular tissue protein Li 117
Gene Aliases: Emk; EMK-1; EMK1; MARK2; PAR-1; Par-1b; Par1b
UniProt ID: (Human) Q7KZI7, (Rat) O08679, (Mouse) Q05512
Entrez Gene ID: (Human) 2011, (Rat) 60328, (Mouse) 13728
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
lipid binding
protein kinase activator activity
poly(A) RNA binding
tau-protein kinase activity
cadherin binding involved in cell-cell adhesion
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
microtubule cytoskeleton organization
mitophagy
neuron migration
protein phosphorylation
positive regulation of neuron projection development
Wnt signaling pathway
peptidyl-threonine phosphorylation
establishment of cell polarity
activation of protein kinase activity
intracellular signal transduction
establishment or maintenance of epithelial cell apical/basal polarity
protein autophosphorylation
regulation of axonogenesis
regulation of cytoskeleton organization
mitochondrion localization
cell-cell adhesion
multicellular organism development
phosphorylation
cell differentiation
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