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Methionine-tRNA ligase (EC 6.1.1.10) catalyzes the chemical reaction: ATP + L-methionine + tRNAMet <--> AMP + diphosphate + L-methionyl-tRNAMetThe 3 substrates of this enzyme are ATP, L-methionine, and tRNA(Met), whereas its 3 products are AMP, diphosphate, and L-methionyl-tRNA(Met).This enzyme participates in 3 metabolic pathways: methionine metabolism, selenoamino acid metabolism, and aminoacyl-trna biosynthesis.
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Protein Aliases: EC 6.1.1.10; methionine tRNA ligase 2, mitochondrial; methionine--tRNA ligase 2; Methionine--tRNA ligase, mitochondrial; methionine-tRNA synthetase 2 (mitochondrial); methionine-tRNA synthetase 2, mitochondrial; Methionyl-tRNA synthetase 2; methionyl-tRNA synthetase 2, mitochondrial; methionyl-tRNA synthetase, mitochondrial; mitochondrial methionine--tRNA ligase; Mitochondrial methionyl-tRNA synthetase; MtMetRS
Gene Aliases: C730026E21Rik; COXPD25; MARS2; MetRS; mtMetRS; RGD1311527
UniProt ID: (Human) Q96GW9, (Mouse) Q499X9
Entrez Gene ID: (Human) 92935, (Mouse) 212679, (Rat) 316403
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