Proteintech

MAVS/VISA Polyclonal Antibody

MAVS/VISA Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 12

MAVS/VISA Antibody (14341-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using (Product # 14341-1-AP) (MAVS; VISA antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

MAVS/VISA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MAVS/VISA Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14341-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 48 publications 48 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 5 publications 5 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MAVS; VISA Fusion Protein Ag5655 (1-347 aa encoded by BC044952)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPFAEDKTY KYICRNFSNF CNVDVVEILP YLPCLTARDQ DRLRATCTLS GNRDTLWHLF NTLQRRPGWV EYFIAALRGC ELVDLADEVA SVYESYQPRT SDRPPDPLEP PSLPAERPGP PTPAAAHSIP YNSCREKEPS YPMPVQETQA PESPGENSEQ ALQTLSPRAI PRNPDGGPLE SSSDLAALSP LTSSGHQEKD TELGSTHTAG ATSSLTPSRG PVSPSVSFQP LARSTPRASR LPGPTGSVVS TGTSFSSSSP GLASAGAAEG KQGAESDQAE PIICSSGAEA PANSLPSKVP TTLMPVNTVA LKVPANPASV STVPSKLPTS SKPPGAVPSN ALTNPAPS (1-347 aa encoded by BC044952)

Target Information

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. Multiple isoforms of MAVS are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.

Nature chemical biology

Zhao X,Stein KR,Chen V,Griffin ME,Lairson LL,Hang HC

Sun Oct 01 00:00:00 EDT 2023

TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination.

The Journal of biological chemistry

Chen YY,Ran XH,Ni RZ,Mu D

Mon May 01 00:00:00 EDT 2023

Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses.

Nature communications

Deng S,He W,Gong AY,Li M,Wang Y,Xia Z,Zhang XT,Huang Pacheco AS,Naqib A,Jenkins M,Swanson PC,Drescher KM,Strauss-Soukup JK,Belshan M,Chen XM

Thu Mar 16 00:00:00 EDT 2023

Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses.

Nature communications

Deng S,He W,Gong AY,Li M,Wang Y,Xia Z,Zhang XT,Huang Pacheco AS,Naqib A,Jenkins M,Swanson PC,Drescher KM,Strauss-Soukup JK,Belshan M,Chen XM

Thu Mar 16 00:00:00 EDT 2023

TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.

Signal transduction and targeted therapy

Zheng W,Zhou Z,Rui Y,Ye R,Xia F,Guo F,Liu X,Su J,Lou M,Yu XF

Fri Feb 24 00:00:00 EST 2023

A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Ding N,You AB,Yang H,Hu GS,Lai CP,Liu W,Ye F

Thu Jun 01 00:00:00 EDT 2023

CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.

The EMBO journal

Yi J,Wang L,Hu GS,Zhang YY,Du J,Ding JC,Ji X,Shen HF,Huang HH,Ye F,Liu W

Mon May 15 00:00:00 EDT 2023

IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.

Viruses

Chen L,Li X,Deng Y,Bi Y,Yan Z,Yang Y,Zhang X,Li H,Xie J,Feng R

Tue Mar 28 00:00:00 EDT 2023

Heterogeneous Nuclear Protein U Degraded the m⁶A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.

Journal of virology

Zhou H,Yan Y,Gao J,Ma M,Liu Y,Shi X,Zhang Q,Xu X

Tue Feb 28 00:00:00 EST 2023

ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.

Developmental cell

Yi J,Wang L,Du J,Wang M,Shen H,Liu Z,Qin Y,Liu J,Hu G,Xiao R,Ding J,Chen X,Wang H,Huang H,Ouyang G,Liu W

Mon May 08 00:00:00 EDT 2023

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses.

Proceedings of the National Academy of Sciences of the United States of America

Carlson RJ,Leiken MD,Guna A,Hacohen N,Blainey PC

Tue Apr 18 00:00:00 EDT 2023

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses.

Proceedings of the National Academy of Sciences of the United States of America

Carlson RJ,Leiken MD,Guna A,Hacohen N,Blainey PC

Tue Apr 18 00:00:00 EDT 2023

DDX56 inhibits PRV replication through regulation of IFN-β signaling pathway by targeting cGAS.

Frontiers in microbiology

Xie J,Li X,Yang S,Yan Z,Chen L,Yang Y,Li D,Zhang X,Feng R

Tue Sep 13 00:00:00 EDT 2022

Antiviral Effect of Selenomethionine on Porcine Deltacoronavirus in Pig Kidney Epithelial Cells.

Frontiers in microbiology

Ren Z,Jia G,He H,Ding T,Yu Y,Zuo Z,Hu Y,Zhong Z,Yu S,Deng H,Shen L,Cao S,Peng G,Wang Y,Cai D,Gou L,Ma X,Liu H,Zhou Z,Deng Y,Yang D,Deng J

Sat Mar 05 00:00:00 EST 2022

MiR-29a inhibits MPP + - Induced cell death and inflammation in Parkinson's disease model in vitro by potential targeting of MAVS.

European journal of pharmacology

Yang YL,Lin TK,Huang YH

Sat Nov 05 00:00:00 EDT 2022

STING1 is essential for an RNA-virus triggered autophagy.

Autophagy

Zhang R,Qin X,Yang Y,Zhu X,Zhao S,Zhang Z,Su Q,Zhao Z,Yin X,Meng X,Zhang Z,Li Y

Fri Apr 01 00:00:00 EDT 2022

Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.

Journal of virology

Zhang R,Lin H,You Q,Zhang Z,Bai L,Chen F,Zhu X,Zhang Z,Li Y

Wed Oct 26 00:00:00 EDT 2022

BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.

Frontiers in immunology

Huang JP,Li J,Xiao YP,Xu LG

Thu Sep 08 00:00:00 EDT 2022

BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.

Frontiers in immunology

Huang JP,Li J,Xiao YP,Xu LG

Thu Sep 08 00:00:00 EDT 2022

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.

Journal of virology

Rebendenne A,Valadão ALC,Tauziet M,Maarifi G,Bonaventure B,McKellar J,Planès R,Nisole S,Arnaud-Arnould M,Moncorgé O,Goujon C

Thu Mar 25 00:00:00 EDT 2021

Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.

Frontiers in immunology

Yang B,Zhang G,Qin X,Huang Y,Ren X,Sun J,Ma S,Liu Y,Song D,Liu Y,Cui Y,Wang H,Wang J

Thu Dec 23 00:00:00 EST 2021

Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.

Frontiers in immunology

Yang B,Zhang G,Qin X,Huang Y,Ren X,Sun J,Ma S,Liu Y,Song D,Liu Y,Cui Y,Wang H,Wang J

Thu Dec 23 00:00:00 EST 2021

Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.

Autophagy

Wang R,Zhu Y,Ren C,Yang S,Tian S,Chen H,Jin M,Zhou H

Mon Feb 01 00:00:00 EST 2021

Curcumol inhibits encephalomyocarditis virus by promoting IFN-β secretion.

BMC veterinary research

Zheng J,Xu Y,Khan A,Sun P,Sun Y,Fan K,Yin W,Wang S,Li H,Sun N

Thu Sep 30 00:00:00 EDT 2021

PINK1 Inhibits Multimeric Aggregation and Signaling of MAVS and MAVS-Dependent Lung Pathology.

American journal of respiratory cell and molecular biology

Kim SH,Shin HJ,Yoon CM,Lee SW,Sharma L,Dela Cruz CS,Kang MJ

Sat May 01 00:00:00 EDT 2021

PINK1 Inhibits Multimeric Aggregation and Signaling of MAVS and MAVS-Dependent Lung Pathology.

American journal of respiratory cell and molecular biology

Kim SH,Shin HJ,Yoon CM,Lee SW,Sharma L,Dela Cruz CS,Kang MJ

Sat May 01 00:00:00 EDT 2021

Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury.

Journal of inflammation research

Zhu Y,Huang G,Yang Y,Yong C,Yu X,Wang G,Yi L,Gao K,Tian F,Qian S,Zhou E,Zou Y

Fri Apr 29 00:00:00 EDT 2022

The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.

Cell reports

Li S,Kuang M,Chen L,Li Y,Liu S,Du H,Cao L,You F

Tue Jan 19 00:00:00 EST 2021

The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.

Cell reports

Li S,Kuang M,Chen L,Li Y,Liu S,Du H,Cao L,You F

Tue Jan 19 00:00:00 EST 2021

Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.

Cell reports

Shen Y,Tang K,Chen D,Hong M,Sun F,Wang S,Ke Y,Wu T,Sun R,Qian J,Du Y

Tue Jun 22 00:00:00 EDT 2021

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS.

Frontiers in immunology

Li W,Qiao J,You Q,Zong S,Peng Q,Liu Y,Hu S,Liu W,Li S,Shu X,Sun B

Tue Dec 14 00:00:00 EST 2021

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS.

Frontiers in immunology

Li W,Qiao J,You Q,Zong S,Peng Q,Liu Y,Hu S,Liu W,Li S,Shu X,Sun B

Tue Dec 14 00:00:00 EST 2021

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS.

Frontiers in immunology

Li W,Qiao J,You Q,Zong S,Peng Q,Liu Y,Hu S,Liu W,Li S,Shu X,Sun B

Tue Dec 14 00:00:00 EST 2021

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS.

Frontiers in immunology

Li W,Qiao J,You Q,Zong S,Peng Q,Liu Y,Hu S,Liu W,Li S,Shu X,Sun B

Tue Dec 14 00:00:00 EST 2021

Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.

Journal of immunology (Baltimore, Md. : 1950)

Zuo Q,Cheng Z,Zhang G,Xia Y,Xu G,Cao W,Yang X,Fu Y,He R,Fang P,Guo Y,Nie L,Huang Y,Liu L,Zhan J,Liu S,Zhu Y

Thu Jul 15 00:00:00 EDT 2021

HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5.

Frontiers in microbiology

Li X,Ma R,Wu B,Niu Y,Li H,Li D,Xie J,Idris A,Feng R

Wed Dec 15 00:00:00 EST 2021

Inhibition of MAVS Aggregation-Mediated Type-I Interferon Signaling by Foot-and-Mouth Disease Virus VP3.

Viruses

Ekanayaka P,Lee BH,Weerawardhana A,Chathuranga K,Park JH,Lee JS

Mon Sep 06 00:00:00 EDT 2021

Induction of autophagy and suppression of type I IFN secretion by CSFV.

Autophagy

Xie B,Zhao M,Song D,Wu K,Yi L,Li W,Li X,Wang K,Chen J

Thu Apr 01 00:00:00 EDT 2021

Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.

Theranostics

Li W,Luo Z,Yan CY,Wang XH,He ZJ,Ouyang SH,Yan C,Liu LF,Zhou QQ,Mu HL,Gong HB,Duan WJ,Liang L,Kurihara H,Feng D,Li YF,He RR

Tue Jun 01 00:00:00 EDT 2021

A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.

The Journal of biological chemistry

Min YQ,Ning YJ,Wang H,Deng F

Fri Jul 10 00:00:00 EDT 2020

DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy.

BMC biology

Szymura SJ,Bernal GM,Wu L,Zhang Z,Crawley CD,Voce DJ,Campbell PA,Ranoa DE,Weichselbaum RR,Yamini B

Tue Mar 24 00:00:00 EDT 2020

Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS.

Signal transduction and targeted therapy

Luo Z,Liu LF,Jiang YN,Tang LP,Li W,Ouyang SH,Tu LF,Wu YP,Gong HB,Yan CY,Jiang S,Lu YH,Liu T,Jiang Z,Kurihara H,Yu Y,Yao XS,Li YF,He RR

Fri Sep 18 00:00:00 EDT 2020

Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS.

Signal transduction and targeted therapy

Luo Z,Liu LF,Jiang YN,Tang LP,Li W,Ouyang SH,Tu LF,Wu YP,Gong HB,Yan CY,Jiang S,Lu YH,Liu T,Jiang Z,Kurihara H,Yu Y,Yao XS,Li YF,He RR

Fri Sep 18 00:00:00 EDT 2020

Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS.

Signal transduction and targeted therapy

Luo Z,Liu LF,Jiang YN,Tang LP,Li W,Ouyang SH,Tu LF,Wu YP,Gong HB,Yan CY,Jiang S,Lu YH,Liu T,Jiang Z,Kurihara H,Yu Y,Yao XS,Li YF,He RR

Fri Sep 18 00:00:00 EDT 2020

Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS.

Signal transduction and targeted therapy

Luo Z,Liu LF,Jiang YN,Tang LP,Li W,Ouyang SH,Tu LF,Wu YP,Gong HB,Yan CY,Jiang S,Lu YH,Liu T,Jiang Z,Kurihara H,Yu Y,Yao XS,Li YF,He RR

Fri Sep 18 00:00:00 EDT 2020

TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.

The Journal of experimental medicine

Zhu Q,Yu T,Gan S,Wang Y,Pei Y,Zhao Q,Pei S,Hao S,Yuan J,Xu J,Hou F,Wu X,Peng C,Wu P,Qin J,Xiao Y

Mon Jul 06 00:00:00 EDT 2020

The Japanese Encephalitis Virus NS1' Protein Inhibits Type I IFN Production by Targeting MAVS.

Journal of immunology (Baltimore, Md. : 1950)

Zhou D,Li Q,Jia F,Zhang L,Wan S,Li Y,Song Y,Chen H,Cao S,Ye J

Sun Mar 01 00:00:00 EST 2020

Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation.

Immunity

Wang Y,Wang P,Zhang Y,Xu J,Li Z,Li Z,Zhou Z,Liu L,Cao X

Tue Dec 15 00:00:00 EST 2020

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.

Autophagy

Wang R,Zhu Y,Lin X,Ren C,Zhao J,Wang F,Gao X,Xiao R,Zhao L,Chen H,Jin M,Ma W,Zhou H

Mon Jul 01 00:00:00 EDT 2019

NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.

Journal of immunology (Baltimore, Md. : 1950)

Xia Z,Xu G,Nie L,Liu L,Peng N,He Q,Zuo Q,Zhou Y,Cao Z,Liu S,Zhu Y

Thu Aug 15 00:00:00 EDT 2019

Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells.

Veterinary and comparative oncology

Igase M,Shousu K,Fujiki N,Sakurai M,Bonkobara M,Hwang CC,Coffey M,Noguchi S,Nemoto Y,Mizuno T

Sat Jun 01 00:00:00 EDT 2019

Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro.

Frontiers in pharmacology

Luo Z,Liu LF,Wang XH,Li W,Jie C,Chen H,Wei FQ,Lu DH,Yan CY,Liu B,Kurihara H,Li YF,He RR

Tue Sep 29 00:00:00 EDT 2020

The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.

Cell reports

Wang K,Ma H,Liu H,Ye W,Li Z,Cheng L,Zhang L,Lei Y,Shen L,Zhang F

Tue May 14 00:00:00 EDT 2019

Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.

Journal of virology

Burgess HM,Mohr I

Wed Aug 01 00:00:00 EDT 2018

Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.

Journal of virology

Burgess HM,Mohr I

Wed Aug 01 00:00:00 EDT 2018

TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.

Journal of immunology (Baltimore, Md. : 1950)

Xing J,Zhang A,Minze LJ,Li XC,Zhang Z

Sun Jul 01 00:00:00 EDT 2018

TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.

Journal of immunology (Baltimore, Md. : 1950)

Xing J,Zhang A,Minze LJ,Li XC,Zhang Z

Sun Jul 01 00:00:00 EDT 2018

MiR-3470b promotes bovine ephemeral fever virus replication via directly targeting mitochondrial antiviral signaling protein (MAVS) in baby hamster Syrian kidney cells.

BMC microbiology

Hou P,Wang H,Zhao G,Hu G,Xia X,He H

Thu Dec 27 00:00:00 EST 2018

MiR-3470b promotes bovine ephemeral fever virus replication via directly targeting mitochondrial antiviral signaling protein (MAVS) in baby hamster Syrian kidney cells.

BMC microbiology

Hou P,Wang H,Zhao G,Hu G,Xia X,He H

Thu Dec 27 00:00:00 EST 2018

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.

Nature communications

Zhou P,Ding X,Wan X,Liu L,Yuan X,Zhang W,Hui X,Meng G,Xiao H,Li B,Zhong J,Hou F,Deng L,Zhang Y

Wed Mar 28 00:00:00 EDT 2018

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.

Nature communications

Zhou P,Ding X,Wan X,Liu L,Yuan X,Zhang W,Hui X,Meng G,Xiao H,Li B,Zhong J,Hou F,Deng L,Zhang Y

Wed Mar 28 00:00:00 EDT 2018

GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation.

PLoS pathogens

Zhang X,Zhu C,Wang T,Jiang H,Ren Y,Zhang Q,Wu K,Liu F,Liu Y,Wu J

Sat Apr 01 00:00:00 EDT 2017

GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation.

PLoS pathogens

Zhang X,Zhu C,Wang T,Jiang H,Ren Y,Zhang Q,Wu K,Liu F,Liu Y,Wu J

Sat Apr 01 00:00:00 EDT 2017

Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.

Oncotarget

Jie C,Luo Z,Chen H,Wang M,Yan C,Mao ZF,Xiao GK,Kurihara H,Li YF,He RR

Fri Dec 01 00:00:00 EST 2017

Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.

Oncotarget

Jie C,Luo Z,Chen H,Wang M,Yan C,Mao ZF,Xiao GK,Kurihara H,Li YF,He RR

Fri Dec 01 00:00:00 EST 2017

Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.

Oncotarget

Jie C,Luo Z,Chen H,Wang M,Yan C,Mao ZF,Xiao GK,Kurihara H,Li YF,He RR

Fri Dec 01 00:00:00 EST 2017

Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.

Oncotarget

Jie C,Luo Z,Chen H,Wang M,Yan C,Mao ZF,Xiao GK,Kurihara H,Li YF,He RR

Fri Dec 01 00:00:00 EST 2017

RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.

The EMBO journal

Gu M,Liu Z,Lai R,Liu S,Lin W,Ouyang C,Ye S,Huang H,Wang X

Thu Dec 01 00:00:00 EST 2016

RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.

The EMBO journal

Gu M,Liu Z,Lai R,Liu S,Lin W,Ouyang C,Ye S,Huang H,Wang X

Thu Dec 01 00:00:00 EST 2016

Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1.

Journal of virology

Hwang KY,Choi YB

Fri Jan 01 00:00:00 EST 2016

Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1.

Journal of virology

Hwang KY,Choi YB

Fri Jan 01 00:00:00 EST 2016

Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.

Journal of virology

Zhang LK,Xin QL,Zhu SL,Wan WW,Wang W,Xiao G

Tue Nov 15 00:00:00 EST 2016

Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.

Journal of virology

Zhang LK,Xin QL,Zhu SL,Wan WW,Wang W,Xiao G

Tue Nov 15 00:00:00 EST 2016

MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS).

Oncotarget

Wan S,Ashraf U,Ye J,Duan X,Zohaib A,Wang W,Chen Z,Zhu B,Li Y,Chen H,Cao S

Tue Nov 22 00:00:00 EST 2016

Porcine reproductive and respiratory syndrome virus 3C protease cleaves the mitochondrial antiviral signalling complex to antagonize IFN-β expression.

The Journal of general virology

Dong J,Xu S,Wang J,Luo R,Wang D,Xiao S,Fang L,Chen H,Jiang Y

Thu Oct 01 00:00:00 EDT 2015

Porcine reproductive and respiratory syndrome virus 3C protease cleaves the mitochondrial antiviral signalling complex to antagonize IFN-β expression.

The Journal of general virology

Dong J,Xu S,Wang J,Luo R,Wang D,Xiao S,Fang L,Chen H,Jiang Y

Thu Oct 01 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; Cardif; IFN-B promoter stimulator 1; Interferon beta promoter stimulator protein 1; IPS-1; MAVS; Mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adaptor; Virus-induced-signaling adapter; VISA

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Gene Aliases: CARDIF; IPS-1; IPS1; KIAA1271; MAVS; VISA

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UniProt ID: (Human) Q7Z434

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Entrez Gene ID: (Human) 57506

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Function(s)

signal transducer activity protein binding protein kinase binding CARD domain binding

Process(es)

Performance Guarantee

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MAVS/VISA Polyclonal Antibody

MAVS/VISA Antibody (14341-1-AP) in ICC/IF

Product Details

14341-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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