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Product Details
19573-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MCM-BP Fusion Protein Ag13750 (291-640 aa encoded by BC004183)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AEEQRVHSP PASLVPRIHV ILAQKLQHIN PLLPACLNKE ESKTFVSSFM SELSPVRAEL LGFLTHALLG DSLAAEYLIL HLISTVYTRR DVLPLGKFTV NLSGCPRNST FTEHLYRIIQ HLVPASFRLQ MTIENMNHLK FIPHKDYTAN RLVSGLLQLP SNTSLVIDET LLEQGQLDTP GVHNVTALSN LITWQKVDYD FSYHQMEFPC NINVFITSEG RSLLPADCQI HLQPQLIPPN MEEYMNSLLS AVLPSVLNKF RIYLTLLRFL EYSISDEITK AVEDDFVEMR KNDPQSITAD DLHQLLVVAR CLSLSAGQTT LSRERWLRAK QLESLRRTRL QQQKCVNGNE L (291-640 aa encoded by BC004183)
Target Information
MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cj119; MCM-binding protein; MCM-BP; Mini-chromosome maintenance complex-binding protein; minichromosome maintenance complex-binding protein
Gene Aliases: 1110007A13Rik; AU017382; BC025641; C10orf119; MCM-BP; MCMBP; RGD1306730
UniProt ID: (Human) Q9BTE3, (Rat) B1H268, (Mouse) Q8R3C0
Entrez Gene ID: (Human) 79892, (Rat) 309009, (Mouse) 210711
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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