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Product Details
H00004221-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEN1 (AAH02544.1, 1 a.a. approximately 575 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED HAWSWLYLKG SYMRCDRKME VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA QVPAPAASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP SDYTLSFLKR QRKGL
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Menin; multiple endocrine neoplasia I
Gene Aliases: MEAI; MEN1; SCG2
UniProt ID: (Human) O00255
Entrez Gene ID: (Human) 4221
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
mitotic cell cycle
negative regulation of protein phosphorylation
osteoblast development
type B pancreatic cell differentiation
DNA repair
transcription, DNA-templated
cellular response to DNA damage stimulus
brain development
negative regulation of cell proliferation
response to UV
response to gamma radiation
negative regulation of cell-substrate adhesion
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of protein binding
regulation of activin receptor signaling pathway
histone lysine methylation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of osteoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
decidualization
negative regulation of epithelial cell proliferation
negative regulation of telomerase activity
regulation of type B pancreatic cell proliferation
cellular response to glucose stimulus
cellular response to peptide hormone stimulus
response to transforming growth factor beta
negative regulation of cell cycle G1/S phase transition
beta-catenin-TCF complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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