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Product Details
PA5-100617
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human UBE2V2(Accession Q15819), corresponding to amino acid residues V67-V117.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850124
Product Specific Information
Antibody detects endogenous levels of total MMS2.
Target Information
The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains (4,5) UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1 alpha,25-dihydroxyvitamin D3-inducible; DDVit 1; EDAF-1; EDPF-1; enterocyte differentiation promoting factor; Enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; Enterocyte differentiation-promoting factor 1; meth; methyl methanesulfonate sensitive 2; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of; MMS2 homolog; Ubc-like protein MMS2; ubiquitin conjugating enzyme E2 variant 2; Ubiquitin-conjugating enzyme E2 variant 2; ubiquitin-conjugating enzyme E2v2; Ubiquitin-conjugating enzyme variant MMS2; Vitamin D3-inducible protein
Gene Aliases: 1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; AI848315; C81524; DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1; MMS2; UBE2V2; UEV-2; UEV2
UniProt ID: (Human) Q15819, (Rat) Q7M767, (Mouse) Q9D2M8
Entrez Gene ID: (Human) 7336, (Rat) 287927, (Mouse) 70620
protein polyubiquitination
DNA double-strand break processing
regulation of DNA repair
postreplication repair
double-strand break repair via nonhomologous end joining
cell proliferation
positive regulation of neuron projection development
protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
error-free postreplication DNA repair
negative regulation of neuron apoptotic process
positive regulation of DNA repair
positive regulation of synapse assembly
protein K63-linked ubiquitination
global genome nucleotide-excision repair
Performance Guarantee
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