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Product Details
PA5-30648
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 147 and 370 of Human Macro H2A.2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2548122
Product Specific Information
Recommended positive controls: mouse brain, human H2AFY2-transfected 293T.
Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (84%), Chicken (95%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Core histone macro-H2A.2; core histone macroH2A2.2; H2A histone family, member Y2; Histone macroH2A2; histone mH2A2; mH2A2
Gene Aliases: H2AFY2; H2afy3; MACROH2A2
UniProt ID: (Human) Q9P0M6, (Mouse) Q8CCK0
Entrez Gene ID: (Human) 55506, (Mouse) 404634
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
nucleosome assembly
chromatin silencing
brain development
dosage compensation
covalent chromatin modification
positive regulation of keratinocyte differentiation
negative regulation of gene expression, epigenetic
establishment of protein localization to chromatin
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
chromatin modification
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