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Product Details
26161-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mcp1 Fusion Protein Ag24085
Conjugate
Form
Liquid
Concentration
250 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; H-MCP-1; HC11; MCAF; MCP-1; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; Platelet-derived growth factor-inducible protein JE; RP23-350G1.3; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; Small-inducible cytokine A2
Gene Aliases: AI323594; CCL2; GDCF-2; HC11; HSMCR30; JE; MCAF; MCP-1; MCP1; SCYA2; Sigje; SMC-CF
UniProt ID: (Human) P13500, (Mouse) P10148
Entrez Gene ID: (Human) 6347, (Mouse) 20296
MAPK cascade
angiogenesis
response to hypoxia
positive regulation of leukocyte mediated cytotoxicity
positive regulation of endothelial cell proliferation
leukocyte migration involved in inflammatory response
monocyte chemotaxis
positive regulation of cellular extravasation
protein phosphorylation
cellular calcium ion homeostasis
chemotaxis
inflammatory response
humoral immune response
cytoskeleton organization
cell adhesion
signal transduction
cell surface receptor signaling pathway
transforming growth factor beta receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
JAK-STAT cascade
aging
regulation of cell shape
response to heat
response to wounding
response to mechanical stimulus
response to bacterium
organ morphogenesis
response to gamma radiation
regulation of vascular endothelial growth factor production
positive regulation of macrophage chemotaxis
response to activity
negative regulation of angiogenesis
viral genome replication
cytokine-mediated signaling pathway
cellular homeostasis
neutrophil chemotaxis
organ regeneration
lipopolysaccharide-mediated signaling pathway
response to progesterone
positive regulation of tumor necrosis factor production
cellular response to insulin stimulus
positive regulation of collagen biosynthetic process
response to vitamin B3
negative regulation of glial cell apoptotic process
helper T cell extravasation
cellular response to drug
cellular response to macrophage colony-stimulating factor stimulus
cellular response to platelet-derived growth factor stimulus
PERK-mediated unfolded protein response
response to amino acid
protein kinase B signaling
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
astrocyte cell migration
cellular response to fibroblast growth factor stimulus
response to ethanol
response to antibiotic
vascular endothelial growth factor receptor signaling pathway
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of inflammatory response
positive regulation of synaptic transmission
positive regulation of T cell activation
positive regulation of nitric-oxide synthase biosynthetic process
maternal process involved in female pregnancy
maternal process involved in parturition
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to ATP
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to high density lipoprotein particle stimulus
cellular response to organic cyclic compound
cellular response to dexamethasone stimulus
positive regulation of monocyte chemotaxis
positive regulation of immune complex clearance by monocytes and macrophages
positive regulation of calcium ion import
positive regulation of protein targeting to membrane
positive regulation of apoptotic cell clearance
negative regulation of natural killer cell chemotaxis
positive regulation of leukocyte migration
immune response
glial cell migration
positive regulation of cell-cell adhesion
monocyte homeostasis
positive regulation of cell adhesion
eosinophil chemotaxis
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