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Product Details
PA5-109275
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human WASL aa 89-295
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854686
Product Specific Information
Positive Control: SH-SY-5Y, SiHa, SK-Br-3, rat brain tissue, human small intestine tissue.
Target Information
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin nucleation-promoting factor WASL; DKFZp779G0847; MGC48327; n wasp; N-WASP; Neural Wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome-like
Gene Aliases: N-WASP; NWASP; WASL; WASPB
UniProt ID: (Human) O00401
Entrez Gene ID: (Human) 8976
transcription, DNA-templated
regulation of transcription, DNA-templated
protein complex assembly
membrane budding
movement of cell or subcellular component
mitotic nuclear division
actin polymerization or depolymerization
response to bacterium
vesicle organization
vesicle transport along actin filament
regulation of protein localization
cellular protein complex localization
Fc-gamma receptor signaling pathway involved in phagocytosis
ephrin receptor signaling pathway
regulation of nitric-oxide synthase activity
cell division
positive regulation of filopodium assembly
spindle localization
negative regulation of membrane tubulation
positive regulation of clathrin-mediated endocytosis
negative regulation of lymphocyte migration
positive regulation of Arp2/3 complex-mediated actin nucleation
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