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Invitrogen
NECAB3 Polyclonal Antibody
FIGURE: 1 / 5
NECAB3 Antibody (PA5-101422) in IHC (P)
Immunohistochemistry analysis of NECAB3 in rat testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with NECAB3 polyclonal antibody (Product # PA5-101422) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101422
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NECAB3(Accession Q96P71), corresponding to amino acid residues Q184-L234.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850858
Product Specific Information
Antibody detects endogenous levels of total NECAB3.
Target Information
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: amyloid beta (A4) precursor protein-binding family A member 1 binding protein; amyloid beta (A4) precursor protein-binding, family A, member 1 binding protein; amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein; amyloid beta A4 protein-binding family A member 2-binding protein; Amyloid-beta A4 protein-binding family A member 2-binding protein; EF-hand calcium binding protein 3; mXB51; N-terminal EF-hand calcium-binding protein 3; Nek2-interacting protein 1; Neuronal calcium-binding protein 3; neuronal calcium-binding protein NECAB3; synaptotagmin interacting protein 2; synaptotagmin interacting protein STIP3; X11L-binding protein 51
Gene Aliases: 2900010M17Rik; AI853434; APBA2BP; dJ63M2.4; dJ63M2.5; EFCBP3; NECAB3; NIP1; STIP3; SYTIP2; XB51
UniProt ID: (Human) Q9HBW7, (Mouse) Q9D6J4
Entrez Gene ID: (Human) 63941, (Mouse) 56846
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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