Product References
X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation.
The Journal of general physiology
Tandl D,Sponagel T,Alansary D,Fuck S,Smit T,Hehlgans S,Jakob B,Fournier C,Niemeyer BA,Rödel F,Roth B,Moroni A,Thiel G
Published figure using NFATC2 monoclonal antibody (Product # MA1-025) in Immunocytochemistry
Mon May 02 00:00:00 EDT 2022
Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells.
iScience
Dölz M,Hasiuk M,Gagnon JD,Kornete M,Marone R,Bantug G,Kageyama R,Hess C,Ansel KM,Seyres D,Roux J,Jeker LT
MA1-025 was used in Flow Cytometry, ChIP Assay, Gel Shift, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to propose that miR-17∼92 constitutes a central mediator for T cell activation, integrating signals by the TCR and CD28 costimulation by dampening multiple brakes that prevent T cell activation.
Fri Nov 18 00:00:00 EST 2022
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Immunity
Xian H,Liu Y,Rundberg Nilsson A,Gatchalian R,Crother TR,Tourtellotte WG,Zhang Y,Aleman-Muench GR,Lewis G,Chen W,Kang S,Luevanos M,Trudler D,Lipton SA,Soroosh P,Teijaro J,de la Torre JC,Arditi M,Karin M,Sanchez-Lopez E
MA1-025 was used in ChIP assay to conclude that inhibition of ATP and mtDNA synthesis is sufficient for ARDS amelioration.
Tue Jul 13 00:00:00 EDT 2021
Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
Cell cycle (Georgetown, Tex.)
Maksoud MJE,Tellios V,Lu WY
MA1-025 was used in Immunocytochemistry to indicate that iNOS/NO signaling inhibits microglial proliferation through TRPV2-mediated calcium influx, nuclear translocation of the transcription factor NFATC2, and p21 expression.
Mon Feb 01 00:00:00 EST 2021
DYRK1A activates NFATC1 to increase glioblastoma migration.
Cancer medicine
Liu H,Sun Q,Chen S,Chen L,Jia W,Zhao J,Sun X
MA1-025 was used in Western Blotting to propose that the recovery of NFATC1 stability is a key oncogenic event in a large proportion of gliomas, and pharmacological inhibition of DYRK1A by polypeptides could represent a promising therapeutic intervention for GBM.
Wed Sep 01 00:00:00 EDT 2021
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.
Immunity
Tyagi AM,Yu M,Darby TM,Vaccaro C,Li JY,Owens JA,Hsu E,Adams J,Weitzmann MN,Jones RM,Pacifici R
MA1-025 was used in Western Blotting to show butyrate concentrations regulate bone anabolism via Treg cell-mediated regulation of CD8+ T cell Wnt10b production.
Tue Dec 18 00:00:00 EST 2018
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.
Immunity
Tyagi AM,Yu M,Darby TM,Vaccaro C,Li JY,Owens JA,Hsu E,Adams J,Weitzmann MN,Jones RM,Pacifici R
MA1-025 was used in Western Blotting to show butyrate concentrations regulate bone anabolism via Treg cell-mediated regulation of CD8+ T cell Wnt10b production.
Tue Dec 18 00:00:00 EST 2018
Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.
PLoS biology
Alam MS,Gaida MM,Debnath S,Tagad HD,Miller Jenkins LM,Appella E,Rahman MJ,Ashwell JD
Published figure using NFATC2 monoclonal antibody (Product # MA1-025) in Immunofluorescence
Mon Jan 01 00:00:00 EST 2018
Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.
PLoS biology
Alam MS,Gaida MM,Debnath S,Tagad HD,Miller Jenkins LM,Appella E,Rahman MJ,Ashwell JD
Published figure using NFATC2 monoclonal antibody (Product # MA1-025) in Immunofluorescence
Mon Jan 01 00:00:00 EST 2018
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
eLife
Sarikhani M,Mishra S,Maity S,Kotyada C,Wolfgeher D,Gupta MP,Singh M,Sundaresan NR
Published figure using NFATC2 monoclonal antibody (Product # MA1-025) in Western Blot
Mon Mar 05 00:00:00 EST 2018
Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis.
The Journal of clinical investigation
Cao P,Aoki Y,Badri L,Walker NM,Manning CM,Lagstein A,Fearon ER,Lama VN
Published figure using NFATC2 monoclonal antibody (Product # MA1-025) in Western Blot
Mon Apr 03 00:00:00 EDT 2017
Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells.
Journal of leukocyte biology
Rampoldi F,Brunk F,Bonrouhi M,Federico G,Krunic D,Porubsky S,Gröne HJ,Popovic ZV
MA1025 was used in immunocytochemistry to evaluate the potential role of the attachment of myristic acid to the N-terminal glycine of proteins on the activation of gamma delta T cells
Sat Apr 01 00:00:00 EDT 2017
Dual-specificity tyrosine-phosphorylation regulated kinase 1A Gene Transcription is regulated by Myocyte Enhancer Factor 2D.
Scientific reports
Wang P,Wang L,Chen L,Sun X
MA1-025 was used in Chromatin immunoprecipitation to demonstrate that MEF2D could upregulate DYRK1A gene expression through specific activation of DYRK1A isoform 5 gene transcription.
Thu Aug 03 00:00:00 EDT 2017
Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ma B,Yu J,Xie C,Sun L,Lin S,Ding J,Luo J,Cai H
MA1-025 was used in Western Blotting to reveal a previously undescribed mitochondrial translocation of NFAT in microglia responding to extended activation of Toll-like receptor-mediated signalling transduction pathways.
Wed Jul 29 00:00:00 EDT 2015
Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ma B,Yu J,Xie C,Sun L,Lin S,Ding J,Luo J,Cai H
MA1-025 was used in Western Blotting to reveal a previously undescribed mitochondrial translocation of NFAT in microglia responding to extended activation of Toll-like receptor-mediated signalling transduction pathways.
Wed Jul 29 00:00:00 EDT 2015
Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts.
The Journal of biological chemistry
Zanotti S,Smerdel-Ramoya A,Canalis E
MA1-025 was used in western blot to study the ability of NFATc2 to inhibit osteoblast Notch signaling
Fri Jan 04 00:00:00 EST 2013
Calcineurin/NFAT signalling inhibits myeloid haematopoiesis.
EMBO molecular medicine
Fric J,Lim CX,Koh EG,Hofmann B,Chen J,Tay HS,Mohammad Isa SA,Mortellaro A,Ruedl C,Ricciardi-Castagnoli P
Published figure using NFATC2 monoclonal antibody (Product # MA1-025) in Western Blot
Sun Apr 01 00:00:00 EDT 2012
Calcineurin/NFAT signalling inhibits myeloid haematopoiesis.
EMBO molecular medicine
Fric J,Lim CX,Koh EG,Hofmann B,Chen J,Tay HS,Mohammad Isa SA,Mortellaro A,Ruedl C,Ricciardi-Castagnoli P
Published figure using NFATC2 monoclonal antibody (Product # MA1-025) in Western Blot
Sun Apr 01 00:00:00 EDT 2012
Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-κB nuclear accumulation in CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Huang YH,Sojka DK,Fowell DJ
MA1-025 was used in flow cytometry to investigate the mechanism of the suppression of CD4 T cell signaling by regulatory T cells
Wed Feb 01 00:00:00 EST 2012
Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion.
Journal of cell science
Gaudineau B,Fougère M,Guaddachi F,Lemoine F,de la Grange P,Jauliac S
MA1-025 was used in ChIP assay to study the regulation of breast cancer invasiveness by NFAT1 and the role played by lipocalin-2, TWEAKR and TWEAK
Mon Oct 01 00:00:00 EDT 2012
Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex.
Journal of immunology (Baltimore, Md. : 1950)
Ohoka Y,Yokota A,Takeuchi H,Maeda N,Iwata M
MA1-025 was used in immunoprecipitation to investigate the cooperativity between NFATc2 and the RAR/RXR and its effect on CCR9 expression
Sat Jan 15 00:00:00 EST 2011
NFATc1 regulation of TRAIL expression in human intestinal cells.
PloS one
Wang Q,Zhou Y,Weiss HL,Chow CW,Evers BM
MA1-025 was used in EMSA to investigate the regulatory effect of NFATc1 on TRAIL in human intestinal cells
Fri Oct 21 00:00:00 EDT 2011
Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1.
Journal of leukocyte biology
Arimilli S,Sharma SK,Yammani R,Reid SD,Parks GD,Alexander-Miller MA
MA1-025 was used in immunocytochemistry to identify how the function of lung effector cells is inactivated
Tue Jun 01 00:00:00 EDT 2010
FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.
Journal of immunology (Baltimore, Md. : 1950)
Torgerson TR,Genin A,Chen C,Zhang M,Zhou B,Añover-Sombke S,Frank MB,Dozmorov I,Ocheltree E,Kulmala P,Centola M,Ochs HD,Wells AD,Cron RQ
MA1-025 was used in chromatin immunoprecipitation to study the effect of FOXP3 on NFAT-mediated inflammatory gene expression.
Wed Jul 15 00:00:00 EDT 2009
Hypertrophy and transcriptional regulation induced in myogenic cell line L6-C5 by an increase of extracellular calcium.
Journal of cellular physiology
De Arcangelis V,Coletti D,Canato M,Molinaro M,Adamo S,Reggiani C,Naro F
MA1-025 was used in western blot to investigate the effect of calcium concentration on cell growth and gene expresion in myogenic cell line L6-C5
Tue Mar 01 00:00:00 EST 2005
Calcium-dependent activation of interleukin-21 gene expression in T cells.
The Journal of biological chemistry
Kim HP,Korn LL,Gamero AM,Leonard WJ
MA1-025 was used in EMSA to demonstrate the induction of the IL-21 in preactivated T lymphocytes by a calcium signal.
Fri Jul 01 00:00:00 EDT 2005
TRPC3 channels confer cellular memory of recent neuromuscular activity.
Proceedings of the National Academy of Sciences of the United States of America
Rosenberg P,Hawkins A,Stiber J,Shelton JM,Hutcheson K,Bassel-Duby R,Shin DM,Yan Z,Williams RS
Tue Jun 22 00:00:00 EDT 2004
Regulation of the murine Nfatc1 gene by NFATc2.
The Journal of biological chemistry
Zhou B,Cron RQ,Wu B,Genin A,Wang Z,Liu S,Robson P,Baldwin HS
MA1-025 was used in EMSA to investigate the regulatory effect of NFATc2 on the murine Nfatc1 gene.
Fri Mar 22 00:00:00 EST 2002
A T cell-specific enhancer of the human CD40 ligand gene.
The Journal of biological chemistry
Schubert LA,Cron RQ,Cleary AM,Brunner M,Song A,Lu LS,Jullien P,Krensky AM,Lewis DB
MA1-025 was used in EMSA assay to study the transcriptional regulation of human CD40 ligand gene
Fri Mar 01 00:00:00 EST 2002
Double-stranded RNA regulates IL-4 expression.
Journal of immunology (Baltimore, Md. : 1950)
Kehoe KE,Brown MA,Imani F
MA1-025 was used in EMSA to investigate the role of the low concentrations of dsRNA towards the IL-4 expression.
Sat Sep 01 00:00:00 EDT 2001
Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain.
The Journal of biological chemistry
Plyte S,Boncristiano M,Fattori E,Galvagni F,Paccani SR,Majolini MB,Oliviero S,Ciliberto G,Telford JL,Baldari CT
MA1-025 was used in western blot to show that NFAT1-D is expressed in the mouse brain
Fri Apr 27 00:00:00 EDT 2001
The calcineurin-NFAT pathway and muscle fiber-type gene expression.
American journal of physiology. Cell physiology
Swoap SJ,Hunter RB,Stevenson EJ,Felton HM,Kansagra NV,Lang JM,Esser KA,Kandarian SC
MA1-025 was used in western blot to investigate the role of calcineurin-NFAT pathway in the regulation of muscle fiber-type gene expression
Sun Oct 01 00:00:00 EDT 2000
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.
Science (New York, N.Y.)
Chow CW,Rincón M,Cavanagh J,Dickens M,Davis RJ
MA1-025 was used in immunohistochemistry to demonstrate that nuclear accumulation of NFAT4 is regulated by JNK
Fri Nov 28 00:00:00 EST 1997