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This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis.
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Protein Aliases: C3HC type 1; hematopoietic stem/progenitor cell protein 216; hNIPA; nuclear interacting partner of anaplastic lymphoma kinase (ALK); Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; OTTHUMP00000212330; Zinc finger C3HC-type protein 1; zinc finger, C3HC-type containing 1
Gene Aliases: HSPC216; NIPA; ZC3HC1
UniProt ID: (Human) Q86WB0
Entrez Gene ID: (Human) 51530
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