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Product Details
PA5-67597
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human NO66.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2688542
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 60S ribosomal protein L8 histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; FLJ21802; Histone lysine demethylase NO66; hsNO66; lysine-specific demethylase NO66; myc associated protein with JmjC domain; MYC-associated protein with JmjC domain; Nucleolar protein 66; Ribosomal oxygenase 1; Ribosomal oxygenase NO66; ROX; up-regulated in lung cancer 2
Gene Aliases: C14orf169; hsNO66; MAPJD; MNCb-7109; NO66; RIOX1; ROX; URLC2
UniProt ID: (Mouse) Q9JJF3, (Human) Q9H6W3, (Rat) D3ZU57
Entrez Gene ID: (Mouse) 71952, (Human) 79697, (Rat) 314300
sulfonate dioxygenase activity
RNA binding
iron ion binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
histone demethylase activity (H3-K4 specific)
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
histone demethylase activity (H3-K36 specific)
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
transcription, DNA-templated
histone H3-K4 demethylation
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
oxidation-reduction process
histone H3-K36 demethylation
chromatin remodeling
regulation of transcription, DNA-templated
chromatin modification
ribosome biogenesis
peptidyl-amino acid modification
post-translational protein modification
Performance Guarantee
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