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This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
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Protein Aliases: neurotrophic factor 4; neurotrophic factor 5; Neurotrophin 4/5; Neurotrophin 5 (neurotrophin 4/5); neurotrophin 5 (neurotrophin 4/5); Neurotrophin-4; Neurotrophin-5; Neutrophic factor 4; Neutrophic factor 5; NT-4; NT-5; NT4/NT5
Gene Aliases: 2900040K06Rik; AI462899; GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT4/5; NT4P; NT5; Ntf-5; NTF4; NTF5
UniProt ID: (Human) P34130, (Rat) P34131, (Mouse) Q80VU4
Entrez Gene ID: (Human) 4909, (Rat) 25730, (Mouse) 78405
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