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OFD1 Antibody (PA5-112634) in IHC (P)
Immunohistochemistry (Paraffin) analysis of OFD1 in paraffin-embedded human skeletal muscle tissue. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at 37°C, then the primary antibody (1% BSA) was incubated at 4°C overnight. The sample was incubated with a OFD1 polyclonal antibody (Product # PA5-... View More
Product Details
PA5-112634
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Oral-facial-digital syndrome 1 protein (598-771AA)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2867369
Target Information
This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Centriole and centriolar satellite protein OFD1; Oral-facial-digital syndrome 1 protein; Oral-facial-digital syndrome 1 protein homolog; Protein 71-7A
Gene Aliases: 71-7A; CXorf5; DXGgc7e; JBTS10; OFD1; ORF2; RP23; SGBS2
UniProt ID: (Human) O75665, (Mouse) Q80Z25
Entrez Gene ID: (Human) 8481, (Mouse) 237222
G2/M transition of mitotic cell cycle
mitotic nuclear division
centriole replication
cilium morphogenesis
epithelial cilium movement involved in determination of left/right asymmetry
mitotic spindle assembly
embryonic body morphogenesis
cell projection organization
axoneme assembly
negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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