Proteintech

OGDHL Polyclonal Antibody

OGDHL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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OGDHL Antibody (17110-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain using 17110-1-AP (OGDHL antibody) at dilution of 1:100 (under 40x lens).

OGDHL Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17110-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OGDHL Fusion Protein Ag10794 (661-1010 aa encoded by BC026320)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SGQDVERGT FSHRHHVLHD QEVDRRTCVP MNHLWPDQAP YTVCNSSLSE YGVLGFELGY AMASPNALVL WEAQFGDFHN TAQCIIDQFI STGQAKWVRH NGIVLLLPHG MEGMGPEHSS ARPERFLQMS NDDSDAYPAF TKDFEVSQLY DCNWIVVNCS TPANYFHVLR RQILLPFRKP LIIFTPKSLL RHPEAKSSFD QMVSGTSFQR VIPEDGAAAR APEQVQRLIF CTGKVYYDLV KERSSQDLEE KVAITRLEQI SPFPFDLIKQ EAEKYPGAEL AWCQEEHKNM GYYDYISPRF MTILRRARPI WYVGRDPAAA PATGNRNTHL VSLKKFLDTA FNLQAFEGKT F (661-1010 aa encoded by BC026320)

Target Information

The function of OGDHL remains unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.

Cancer science

Dai W,Li Y,Sun W,Ji M,Bao R,Chen J,Xu S,Dai Y,Chen Y,Liu W,Ge C,Sun W,Mo W,Guo C,Xu X

Sat Apr 01 00:00:00 EDT 2023

Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.

Cancer science

Dai W,Li Y,Sun W,Ji M,Bao R,Chen J,Xu S,Dai Y,Chen Y,Liu W,Ge C,Sun W,Mo W,Guo C,Xu X

Sat Apr 01 00:00:00 EDT 2023

Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.

Cancer science

Dai W,Li Y,Sun W,Ji M,Bao R,Chen J,Xu S,Dai Y,Chen Y,Liu W,Ge C,Sun W,Mo W,Guo C,Xu X

Sat Apr 01 00:00:00 EDT 2023

Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.

Cancer science

Dai W,Li Y,Sun W,Ji M,Bao R,Chen J,Xu S,Dai Y,Chen Y,Liu W,Ge C,Sun W,Mo W,Guo C,Xu X

Sat Apr 01 00:00:00 EDT 2023

CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis.

The Journal of experimental medicine

Xu X,Dennett P,Zhang J,Sherrard A,Zhao Y,Masubuchi T,Bui JD,Chen X,Hui E

Mon Jul 03 00:00:00 EDT 2023

OGDHL ameliorates cognitive impairment and Alzheimer's disease-like pathology via activating Wnt/β-catenin signaling in Alzheimer's disease mice.

Behavioural brain research

Yao L,Xu X,Xu Y,Li C,Xie F,Guo M,Liu Z,Liu X

Thu Feb 10 00:00:00 EST 2022

OGDHL ameliorates cognitive impairment and Alzheimer's disease-like pathology via activating Wnt/β-catenin signaling in Alzheimer's disease mice.

Behavioural brain research

Yao L,Xu X,Xu Y,Li C,Xie F,Guo M,Liu Z,Liu X

Thu Feb 10 00:00:00 EST 2022

Bi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia.

American journal of human genetics

Yap ZY,Efthymiou S,Seiffert S,Vargas Parra K,Lee S,Nasca A,Maroofian R,Schrauwen I,Pendziwiat M,Jung S,Bhoj E,Striano P,Mankad K,Vona B,Cuddapah S,Wagner A,Alvi JR,Davoudi-Dehaghani E,Fallah MS,Gannavarapu S,Lamperti C,Legati A,Murtaza BN,Nadeem MS,Rehman MU,Saeidi K,Salpietro V,von Spiczak S,Sandoval A,Zeinali S,Zeviani M,Reich A,Jang C,Helbig I,Barakat TS,Ghezzi D,Leal SM,Weber Y,Houlden H,Yoon WH

Thu Dec 02 00:00:00 EST 2021

Cardioprotective Role of SIRT5 in Response to Acute Ischemia Through a Novel Liver-Cardiac Crosstalk Mechanism.

Frontiers in cell and developmental biology

Zhou B,Xiao M,Hu H,Pei X,Xue Y,Miao G,Wang J,Li W,Du Y,Zhang P,Wei T

Tue Aug 10 00:00:00 EDT 2021

OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.

Journal of hepatology

Dai W,Xu L,Yu X,Zhang G,Guo H,Liu H,Song G,Weng S,Dong L,Zhu J,Liu T,Guo C,Shen X

Fri May 01 00:00:00 EDT 2020

Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation.

Brain structure & function

Dobolyi A,Bago A,Palkovits M,Nemeria NS,Jordan F,Doczi J,Ambrus A,Adam-Vizi V,Chinopoulos C

Sun Mar 01 00:00:00 EST 2020

Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation.

Brain structure & function

Dobolyi A,Bago A,Palkovits M,Nemeria NS,Jordan F,Doczi J,Ambrus A,Adam-Vizi V,Chinopoulos C

Sun Mar 01 00:00:00 EST 2020

Osteopontin and LDLR Are Upregulated in Hearts of Sudden Cardiac Death Victims With Heart Failure With Preserved Ejection Fraction and Diabetes Mellitus.

Frontiers in cardiovascular medicine

Patel M,Rodriguez D,Yousefi K,John-Williams K,Mendez AJ,Goldberg RB,Lymperopoulos A,Tamariz LJ,Goldberger JJ,Myerburg RJ,Junttila J,Shehadeh LA

Fri Dec 18 00:00:00 EST 2020

Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress.

Translational psychiatry

Tang M,Huang H,Li S,Zhou M,Liu Z,Huang R,Liao W,Xie P,Zhou J

Thu Oct 17 00:00:00 EDT 2019

OGDHL is a modifier of AKT-dependent signaling and NF-κB function.

PloS one

Sen T,Sen N,Noordhuis MG,Ravi R,Wu TC,Ha PK,Sidransky D,Hoque MO

Wed May 01 00:00:00 EDT 2013

OGDHL is a modifier of AKT-dependent signaling and NF-κB function.

PloS one

Sen T,Sen N,Noordhuis MG,Ravi R,Wu TC,Ha PK,Sidransky D,Hoque MO

Wed May 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: 2-oxoglutarate dehydrogenase complex component E1-like; 2-oxoglutarate dehydrogenase-like, mitochondrial; Alpha-ketoglutarate dehydrogenase-like; OGDC-E1-like

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Gene Aliases: KIAA1290; OGDHL

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UniProt ID: (Human) Q9ULD0

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Entrez Gene ID: (Human) 55753, (Mouse) 239017, (Rat) 290566

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Function(s)

oxoglutarate dehydrogenase (succinyl-transferring) activity protein binding thiamine pyrophosphate binding metal ion binding molecular_function dehydrogenase

Process(es)

glycolytic process tricarboxylic acid cycle biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OGDHL Polyclonal Antibody

OGDHL Antibody (17110-1-AP) in IHC (P)

Product Details

17110-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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