Proteintech

OGT Polyclonal Antibody

OGT Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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OGT Antibody (11576-2-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using (Product # 11576-2-AP) (OGT antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

OGT Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11576-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 31 publications 31 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OGT Fusion Protein Ag2160 (1-400 aa encoded by BC014434)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASSVGNVA DSTGLAELAH REYQAGDFEA AERHCMQLWR QEPDNTGVLL LLSSIHFQCR RLDRSAHFST LAIKQNPLLA EAYSNLGNVY KERGQLQEAI EHYRHALRLK PDFIDGYINL AAALVAAGDM EGAVQAYVSA LQYNPDLYCV RSDLGNLLKA LGRLEEAKAC YLKAIETQPN FAVAWSNLGC VFNAQGEIWL AIHHFEKAVT LDPNFLDAYI NLGNVLKEAR IFDRAVAAYL RALSLSPNHA VVHGNLACVY YEQGLIDLAI DTYRRAIELQ PHFPDAYCNL ANALKEKGSV AEAEDCYNTA LRLCPTHADS LNNLANIKRE QGNIEEAVRL YRKALEVFPE FAAAHSNLAS VLQQQGKLQE ALMHYKEAIR ISPTFADAYS NMGNTLKEMQ D (1-400 aa encoded by BC014434)

Target Information

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

[WITHDRAWN] Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction.

Research square

Tatekoshi Y,Shapiro JS,Liu M,Bianco GM,Tatekoshi A,De Jesus A,Koleini N,Wasserstrom JA,Dillmann WH,Weinberg SE,Ardehali H

Wed Jan 25 00:00:00 EST 2023

[WITHDRAWN] Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction.

Research square

Tatekoshi Y,Shapiro JS,Liu M,Bianco GM,Tatekoshi A,De Jesus A,Koleini N,Wasserstrom JA,Dillmann WH,Weinberg SE,Ardehali H

Wed Jan 25 00:00:00 EST 2023

[WITHDRAWN] Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction.

Research square

Tatekoshi Y,Shapiro JS,Liu M,Bianco GM,Tatekoshi A,De Jesus A,Koleini N,Wasserstrom JA,Dillmann WH,Weinberg SE,Ardehali H

Wed Jan 25 00:00:00 EST 2023

O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.

Respiratory research

Xuefei Y,Dongyan L,Tianming L,Hejuan Z,Jianhua F

Mon Jan 16 00:00:00 EST 2023

O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.

Respiratory research

Xuefei Y,Dongyan L,Tianming L,Hejuan Z,Jianhua F

Mon Jan 16 00:00:00 EST 2023

Cancer-associated fibroblast-secreted glucosamine alters the androgen biosynthesis program in prostate cancer via HSD3B1 upregulation.

The Journal of clinical investigation

Cui D,Li J,Zhu Z,Berk M,Hardaway A,McManus J,Chung YM,Alyamani M,Valle S,Tiwari R,Han B,Goudarzi M,Willard B,Sharifi N

Mon Apr 03 00:00:00 EDT 2023

Astragalus Polysaccharide Promotes Doxorubicin-Induced Apoptosis by Reducing O-GlcNAcylation in Hepatocellular Carcinoma.

Cells

Li M,Duan F,Pan Z,Liu X,Lu W,Liang C,Fang Z,Peng P,Jia D

Fri Mar 10 00:00:00 EST 2023

Astragalus Polysaccharide Promotes Doxorubicin-Induced Apoptosis by Reducing O-GlcNAcylation in Hepatocellular Carcinoma.

Cells

Li M,Duan F,Pan Z,Liu X,Lu W,Liang C,Fang Z,Peng P,Jia D

Fri Mar 10 00:00:00 EST 2023

O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression.

Cell death and differentiation

Liu YY,Liu HY,Yu TJ,Lu Q,Zhang FL,Liu GY,Shao ZM,Li DQ

Fri Apr 01 00:00:00 EDT 2022

Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.

Nature chemical biology

Shu XE,Mao Y,Jia L,Qian SB

Tue Feb 01 00:00:00 EST 2022

Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.

Nature chemical biology

Shu XE,Mao Y,Jia L,Qian SB

Tue Feb 01 00:00:00 EST 2022

Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.

Nature chemical biology

Shu XE,Mao Y,Jia L,Qian SB

Tue Feb 01 00:00:00 EST 2022

Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.

Nature chemical biology

Shu XE,Mao Y,Jia L,Qian SB

Tue Feb 01 00:00:00 EST 2022

Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation.

The Journal of biological chemistry

Xu B,Zhang C,Jiang A,Zhang X,Liang F,Wang X,Li D,Liu C,Liu X,Xia J,Li Y,Wang Y,Yang Z,Chen J,Zhou Y,Chen L,Sun H

Fri Jul 01 00:00:00 EDT 2022

Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression.

Cell reports

Yang D,Liu H,Cai Y,Lu K,Zhong X,Xing S,Song W,Zhang Y,Ye L,Zhu X,Wang T,Zhang P,Li ST,Feng J,Jia W,Zhang H,Gao P

Tue Nov 22 00:00:00 EST 2022

The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.

In vitro cellular & developmental biology. Animal

Chen L,Li Y,Zeng S,Duan S,Huang Z,Liang Y

Sun May 01 00:00:00 EDT 2022

The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.

In vitro cellular & developmental biology. Animal

Chen L,Li Y,Zeng S,Duan S,Huang Z,Liang Y

Sun May 01 00:00:00 EDT 2022

Comparative O-GlcNAc Proteomic Analysis Reveals a Role of O-GlcNAcylated SAM68 in Lung Cancer Aggressiveness.

Cancers

Lin CH,Liao CC,Wang SY,Peng CY,Yeh YC,Chen MY,Chou TY

Tue Jan 04 00:00:00 EST 2022

Comparative O-GlcNAc Proteomic Analysis Reveals a Role of O-GlcNAcylated SAM68 in Lung Cancer Aggressiveness.

Cancers

Lin CH,Liao CC,Wang SY,Peng CY,Yeh YC,Chen MY,Chou TY

Tue Jan 04 00:00:00 EST 2022

Comparative O-GlcNAc Proteomic Analysis Reveals a Role of O-GlcNAcylated SAM68 in Lung Cancer Aggressiveness.

Cancers

Lin CH,Liao CC,Wang SY,Peng CY,Yeh YC,Chen MY,Chou TY

Tue Jan 04 00:00:00 EST 2022

O-GlcNAc transferase promotes the nuclear localization of the focal adhesion-associated protein Zyxin to regulate UV-induced cell death.

The Journal of biological chemistry

Zhao Y,Yue S,Zhou X,Guo J,Ma S,Chen Q

Fri Apr 01 00:00:00 EDT 2022

O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation.

Journal of advanced research

Zhang H,Qi J,Pei J,Zhang M,Shang Y,Li Z,Wang Y,Guo J,Sun K,Fan J,Sui L,Xu Y,Kong L,Kong Y

Tue Mar 01 00:00:00 EST 2022

The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity.

Life science alliance

Dragic H,Barthelaix A,Duret C,Le Goupil S,Laprade H,Martin S,Brugière S,Couté Y,Machon C,Guitton J,Rudewicz J,Hofman P,Lebecque S,Chaveroux C,Ferraro-Peyret C,Renno T,Manié SN

Fri Jul 01 00:00:00 EDT 2022

Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation.

Redox biology

Ou W,Liang Y,Qin Y,Wu W,Xie M,Zhang Y,Zhang Y,Ji L,Yu H,Li T

Thu Jul 01 00:00:00 EDT 2021

Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation.

Chinese medicine

Wu F,Shao Q,Cheng Z,Xiong X,Fang K,Zhao Y,Dong R,Xu L,Lu F,Chen G

Mon Aug 16 00:00:00 EDT 2021

Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation.

Chinese medicine

Wu F,Shao Q,Cheng Z,Xiong X,Fang K,Zhao Y,Dong R,Xu L,Lu F,Chen G

Mon Aug 16 00:00:00 EDT 2021

O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.

Biochimica et biophysica acta. General subjects

Xie X,Wu Q,Zhang K,Liu Y,Zhang N,Chen Q,Wang L,Li W,Zhang J,Liu Y

Sun Aug 01 00:00:00 EDT 2021

OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.

Pathology, research and practice

Ge X,Peng X,Li M,Ji F,Chen J,Zhang D

Wed Sep 01 00:00:00 EDT 2021

OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.

Pathology, research and practice

Ge X,Peng X,Li M,Ji F,Chen J,Zhang D

Wed Sep 01 00:00:00 EDT 2021

OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.

Pathology, research and practice

Ge X,Peng X,Li M,Ji F,Chen J,Zhang D

Wed Sep 01 00:00:00 EDT 2021

Dihydroartemisinin Induces O-GlcNAcylation and Improves Cognitive Function in a Mouse Model of Tauopathy.

Journal of Alzheimer's disease : JAD

Xia L,Pang Y,Li J,Wu B,Du Y,Chen Y,Luo M,Wang Y,Dong Z

Tue Jan 04 00:00:00 EST 2022

DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation.

Frontiers in oncology

Su Z,Gao A,Li X,Zou S,He C,Wu J,Ding WQ,Zhou J

Sat Aug 07 00:00:00 EDT 2021

DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation.

Frontiers in oncology

Su Z,Gao A,Li X,Zou S,He C,Wu J,Ding WQ,Zhou J

Sat Aug 07 00:00:00 EDT 2021

DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation.

Frontiers in oncology

Su Z,Gao A,Li X,Zou S,He C,Wu J,Ding WQ,Zhou J

Sat Aug 07 00:00:00 EDT 2021

DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation.

Frontiers in oncology

Su Z,Gao A,Li X,Zou S,He C,Wu J,Ding WQ,Zhou J

Sat Aug 07 00:00:00 EDT 2021

O‑GlcNAcylation contributes to intermittent hypoxia‑associated vascular dysfunction via modulation of MAPKs but not CaMKII pathways.

Molecular medicine reports

Guo X,Deng Y,Zhan L,Shang J,Liu H

Mon Nov 01 00:00:00 EDT 2021

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.

Molecular cell

Marmor-Kollet H,Siany A,Kedersha N,Knafo N,Rivkin N,Danino YM,Moens TG,Olender T,Sheban D,Cohen N,Dadosh T,Addadi Y,Ravid R,Eitan C,Toth Cohen B,Hofmann S,Riggs CL,Advani VM,Higginbottom A,Cooper-Knock J,Hanna JH,Merbl Y,Van Den Bosch L,Anderson P,Ivanov P,Geiger T,Hornstein E

Thu Dec 03 00:00:00 EST 2020

GFPT2 promotes metastasis and forms a positive feedback loop with p65 in colorectal cancer.

American journal of cancer research

Liu L,Pan Y,Ren X,Zeng Z,Sun J,Zhou K,Liang Y,Wang F,Yan Y,Liao W,Ding Y,Liu X,Liang L

Mon Sep 28 00:00:00 EDT 2020

Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.

Nature communications

Liu Y,Chen Q,Zhang N,Zhang K,Dou T,Cao Y,Liu Y,Li K,Hao X,Xie X,Li W,Ren Y,Zhang J

Thu Nov 19 00:00:00 EST 2020

Long non-coding RNA LINC00707 acts as a competing endogenous RNA to enhance cell proliferation in colorectal cancer.

Experimental and therapeutic medicine

Wang H,Luan H,Zhan T,Liu X,Song J,Dai H

Sat Feb 01 00:00:00 EST 2020

O‑GlcNAc modification influences endometrial receptivity by promoting endometrial cell proliferation, migration and invasion.

Oncology reports

Han X,Li X,Liu H,Zhang H,Li A,Dong M,Xu Y,Yan B,Sui L,Kong Y

Fri Nov 01 00:00:00 EDT 2019

MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.

Atherosclerosis

Zhang J,Cai W,Fan Z,Yang C,Wang W,Xiong M,Ma C,Yang J

Fri Nov 01 00:00:00 EDT 2019

O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.

Nature chemical biology

Zhang X,Shu XE,Qian SB

Mon Oct 01 00:00:00 EDT 2018

O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.

Nature chemical biology

Zhang X,Shu XE,Qian SB

Mon Oct 01 00:00:00 EDT 2018

GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion.

Developmental cell

Zhang X,Wang L,Lak B,Li J,Jokitalo E,Wang Y

Mon Apr 23 00:00:00 EDT 2018

GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion.

Developmental cell

Zhang X,Wang L,Lak B,Li J,Jokitalo E,Wang Y

Mon Apr 23 00:00:00 EDT 2018

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.

Haematologica

Wu D,Wang W,Chen W,Lian F,Lang L,Huang Y,Xu Y,Zhang N,Chen Y,Liu M,Nussinov R,Cheng F,Lu W,Huang J

Sat Sep 01 00:00:00 EDT 2018

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.

Haematologica

Wu D,Wang W,Chen W,Lian F,Lang L,Huang Y,Xu Y,Zhang N,Chen Y,Liu M,Nussinov R,Cheng F,Lu W,Huang J

Sat Sep 01 00:00:00 EDT 2018

High O-linked N-acetylglucosamine transferase expression predicts poor survival in patients with early stage lung adenocarcinoma.

Oncotarget

Lin YC,Lin CH,Yeh YC,Ho HL,Wu YC,Chen MY,Chou TY

Tue Jul 24 00:00:00 EDT 2018

High O-linked N-acetylglucosamine transferase expression predicts poor survival in patients with early stage lung adenocarcinoma.

Oncotarget

Lin YC,Lin CH,Yeh YC,Ho HL,Wu YC,Chen MY,Chou TY

Tue Jul 24 00:00:00 EDT 2018

O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress.

Journal of hepatology

Xu W,Zhang X,Wu JL,Fu L,Liu K,Liu D,Chen GG,Lai PB,Wong N,Yu J

Tue Aug 01 00:00:00 EDT 2017

O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress.

Journal of hepatology

Xu W,Zhang X,Wu JL,Fu L,Liu K,Liu D,Chen GG,Lai PB,Wong N,Yu J

Tue Aug 01 00:00:00 EDT 2017

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.

Nature chemical biology

Hu CW,Worth M,Fan D,Li B,Li H,Lu L,Zhong X,Lin Z,Wei L,Ge Y,Li L,Jiang J

Fri Dec 01 00:00:00 EST 2017

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.

Nature chemical biology

Hu CW,Worth M,Fan D,Li B,Li H,Lu L,Zhong X,Lin Z,Wei L,Ge Y,Li L,Jiang J

Fri Dec 01 00:00:00 EST 2017

Identification and characterization of a missense mutation in the O-linked β-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability.

The Journal of biological chemistry

Vaidyanathan K,Niranjan T,Selvan N,Teo CF,May M,Patel S,Weatherly B,Skinner C,Opitz J,Carey J,Viskochil D,Gecz J,Shaw M,Peng Y,Alexov E,Wang T,Schwartz C,Wells L

Fri May 26 00:00:00 EDT 2017

Identification and characterization of a missense mutation in the O-linked β-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability.

The Journal of biological chemistry

Vaidyanathan K,Niranjan T,Selvan N,Teo CF,May M,Patel S,Weatherly B,Skinner C,Opitz J,Carey J,Viskochil D,Gecz J,Shaw M,Peng Y,Alexov E,Wang T,Schwartz C,Wells L

Fri May 26 00:00:00 EDT 2017

Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells.

Oncology letters

Qiao Z,Dang C,Zhou B,Li S,Zhang W,Jiang J,Zhang J,Ma Y,Kong R,Ma Z

Sun May 01 00:00:00 EDT 2016

Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells.

Oncology letters

Qiao Z,Dang C,Zhou B,Li S,Zhang W,Jiang J,Zhang J,Ma Y,Kong R,Ma Z

Sun May 01 00:00:00 EDT 2016

Differential membranous E-cadherin expression, cell proliferation and O-GlcNAcylation between primary and metastatic nodal lesion in colorectal cancer.

Pathology, research and practice

Jang TJ

Mon Feb 01 00:00:00 EST 2016

Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling.

International journal of molecular medicine

Guo X,Shang J,Deng Y,Yuan X,Zhu D,Liu H

Wed Jul 01 00:00:00 EDT 2015

Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling.

International journal of molecular medicine

Guo X,Shang J,Deng Y,Yuan X,Zhu D,Liu H

Wed Jul 01 00:00:00 EDT 2015

Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling.

International journal of molecular medicine

Guo X,Shang J,Deng Y,Yuan X,Zhu D,Liu H

Wed Jul 01 00:00:00 EDT 2015

Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling.

International journal of molecular medicine

Guo X,Shang J,Deng Y,Yuan X,Zhu D,Liu H

Wed Jul 01 00:00:00 EDT 2015

Glucose-insulin-potassium solution protects ventricular myocytes of neonatal rat in an in vitro coverslip ischemia/reperfusion model.

Korean circulation journal

Chun WJ,Nah DY,Bae JH,Chung JW,Lee H,Moon IS

Fri May 01 00:00:00 EDT 2015

Glucose-insulin-potassium solution protects ventricular myocytes of neonatal rat in an in vitro coverslip ischemia/reperfusion model.

Korean circulation journal

Chun WJ,Nah DY,Bae JH,Chung JW,Lee H,Moon IS

Fri May 01 00:00:00 EDT 2015

O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation.

Medical oncology (Northwood, London, England)

Zhu Q,Zhou L,Yang Z,Lai M,Xie H,Wu L,Xing C,Zhang F,Zheng S

Fri Jun 01 00:00:00 EDT 2012

O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation.

Medical oncology (Northwood, London, England)

Zhu Q,Zhou L,Yang Z,Lai M,Xie H,Wu L,Xing C,Zhang F,Zheng S

Fri Jun 01 00:00:00 EDT 2012

O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma.

Journal of biomedical research

Qiao Z,Dang C,Zhou B,Li S,Zhang W,Jiang J,Zhang J,Kong R,Ma Y

Sun Jul 01 00:00:00 EDT 2012

O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma.

Journal of biomedical research

Qiao Z,Dang C,Zhou B,Li S,Zhang W,Jiang J,Zhang J,Kong R,Ma Y

Sun Jul 01 00:00:00 EDT 2012

A Modified Coupled Enzyme Method for O-linked GlcNAc Transferase Activity Assay.

Biological procedures online

Zhang L,Ren F,Li J,Ma X,Wang P

Thu Dec 03 00:00:00 EST 2009

A Modified Coupled Enzyme Method for O-linked GlcNAc Transferase Activity Assay.

Biological procedures online

Zhang L,Ren F,Li J,Ma X,Wang P

Thu Dec 03 00:00:00 EST 2009

Bioinformatics

Protein Aliases: FLJ23071; MGC22921; O linked N-acetylglucosamine transferase; o-glcnac transferase; O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase

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Gene Aliases: 1110038P24Rik; 4831420N21Rik; AI115525; HINCUT-1; HRNT1; O-GLCNAC; OGT; Ogtl

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UniProt ID: (Human) O15294, (Mouse) Q8CGY8, (Rat) P56558

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Entrez Gene ID: (Human) 8473, (Mouse) 108155, (Rat) 26295

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Function(s)

protein binding phosphatidylinositol-3,4,5-trisphosphate binding enzyme activator activity transcription factor binding acetylglucosaminyltransferase activity protein N-acetylglucosaminyltransferase activity protein domain specific binding peptide binding histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K16 specific) monosaccharide binding protein O-GlcNAc transferase activity catalytic activity N-acetyltransferase activity lipid binding transferase activity transferase activity, transferring glycosyl groups protein modifying enzyme

Process(es)

positive regulation of protein phosphorylation glucosamine metabolic process regulation of glycolytic process protein O-linked glycosylation apoptotic process signal transduction response to nutrient negative regulation of peptidyl-threonine phosphorylation positive regulation of granulocyte differentiation forebrain development negative regulation of protein ubiquitination response to insulin cellular response to insulin stimulus circadian regulation of gene expression negative regulation of peptidyl-serine phosphorylation regulation of Rac protein signal transduction positive regulation of catalytic activity histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation positive regulation of cell size positive regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter regulation of insulin receptor signaling pathway phosphatidylinositol-mediated signaling intracellular distribution of mitochondria positive regulation of histone H3-K4 methylation negative regulation of cell death positive regulation of histone H3-K27 methylation protein homotrimerization protein heterotrimerization cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to glucose stimulus histone H3-K4 trimethylation negative regulation of protein targeting to membrane regulation of gluconeogenesis involved in cellular glucose homeostasis cellular response to toxic substance negative regulation of cellular response to hypoxia positive regulation of protein localization to nucleus positive regulation of reactive oxygen species biosynthetic process negative regulation of protein phosphorylation positive regulation of gene expression chromatin modification rhythmic process

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OGT Polyclonal Antibody

OGT Antibody (11576-2-AP) in IHC (P)

Product Details

11576-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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