Invitrogen

P glycoprotein Recombinant Rabbit Monoclonal Antibody (ARC0470)

View all (103) P-Glycoprotein (ABCB1) antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-35257

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0470

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 393-710 of human P Glycoprotein (P08183)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849160

Product Specific Information

Immunogen sequence: EFRNVHFSYP SRKEVKILKG LNLKVQSGQT VALVGNSGCG KSTTVQLMQR LYDPTEGMVS VDGQDIRTIN VRFLREIIGV VSQEPVLFAT TIAENIRYGR ENVTMDEIEK AVKEANAYDF IMKLPHKFDT LVGERGAQLS GGQKQRIAIA RALVRNPKIL LLDEATSALD TESEAVVQVA LDKARKGRTT IVIAHRLSTV RNADVIAGFD DGVIVEKGNH DELMKEKGIY FKLVTMQTAG NEVELENAAD ESKSEIDALE MSSNDSRSSL IRKRSTRRSV RGSQAQDRKL STKEALDESI PPVSFWRIMK LNLTEWPY

Target Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette sub-family B member 1; ATP-binding cassette sub-family B member 1A; ATP-binding cassette sub-family B member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B, member 1A; ATP-binding cassette, subfamily B, member 1B; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; ecotropic viral integration site 32; MDR1A; multi-drug resistance 3; Multidrug resistance protein 1; Multidrug resistance protein 1A; Multidrug resistance protein 1B; Multidrug resistance protein 3; multiple drug resistant 1a; P glycoprotein 1; P glycoprotein 3; P-glycoprotein 1; P-glycoprotein 3; P-glycoprotein/multidrug resistance 1; Phospholipid transporter ABCB1

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Gene Aliases: ABC20; ABCB1; Abcb1a; Abcb1b; Abcb4; CD243; CLCS; Evi32; GP170; mdr; mdr-3; MDR1; Mdr1a; Mdr1b; Mdr3; P-GP; Pgp; Pgy-1; Pgy-3; PGY1; Pgy1-1; Pgy3

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UniProt ID: (Human) P08183, (Mouse) P21447, (Mouse) P06795

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Entrez Gene ID: (Human) 5243, (Mouse) 18671, (Rat) 170913, (Mouse) 18669, (Rat) 24646

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Function(s)
transporter activity protein binding ATP binding xenobiotic-transporting ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding hydrolase activity ATPase activity ATPase activity, coupled drug transmembrane transporter activity ATP-binding cassette (ABC) transporter
Process(es)
G2/M transition of mitotic cell cycle antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent positive regulation of antigen processing and presentation of peptide antigen via MHC class I transport drug transmembrane transport response to drug xenobiotic transport transmembrane transport stem cell proliferation hormone transport drug transport daunorubicin transport drug export negative regulation of cell death establishment of blood-brain barrier positive regulation of response to drug response to hypoxia placenta development lactation circadian rhythm metabolic process response to organic cyclic compound response to nutrient levels response to vitamin D cellular response to mycotoxin response to cadmium ion cellular response to antibiotic cellular response to alkaloid cellular response to estradiol stimulus cellular response to organic cyclic compound cellular hyperosmotic salinity response response to dexamethasone cellular response to dexamethasone stimulus response to thyroxine response to L-glutamate establishment of endothelial blood-brain barrier response to ionizing radiation response to arsenic-containing substance response to steroid hormone cellular response to tumor necrosis factor
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