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Product Details
PA1-24624
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Guinea pig,
Human,
Mouse,
Non-human primate,
Pig,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues D(460) S T S T D P K G L A Q L(472) of rat P2X2.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2157912
Product Specific Information
PA1-24624 is expected to cross react with mouse (100% conserved) and guinea pig (100% conserved) due to sequence homology.
Target Information
P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP receptor; MGC129601; P2X purinoceptor 2; P2X Receptor, subunit 2; P2X2; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 2; purinergic receptor P2X, ligand-gated ion channel, 2
Gene Aliases: DFNA41; P2RX2; P2X2; P2X2a
UniProt ID: (Human) Q9UBL9, (Guinea pig) O70397, (Rat) P49653, (Mouse) Q8K3P1
Entrez Gene ID: (Human) 22953, (Pig) 100736581, (Guinea pig) 100135591, (Rat) 114115, (Mouse) 231602
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ATP binding
ligand-gated ion channel activity
identical protein binding
ion channel activity
copper ion binding
protein binding
drug binding
zinc ion binding
nickel cation binding
phosphatidylinositol binding
mercury ion binding
cadmium ion binding
cobalt ion binding
ligand-gated ion channel
response to hypoxia
detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
neuromuscular synaptic transmission
neuromuscular junction development
blood coagulation
sensory perception of sound
response to carbohydrate
positive regulation of calcium ion transport into cytosol
urinary bladder smooth muscle contraction
peristalsis
response to ATP
purinergic nucleotide receptor signaling pathway
behavioral response to pain
skeletal muscle fiber development
positive regulation of calcium-mediated signaling
sensory perception of taste
protein homooligomerization
cation transmembrane transport
cation transport
chemical synaptic transmission
response to organic substance
neuronal action potential
ion transmembrane transport
protein heterooligomerization
transport
ion transport
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