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Product Details
PALB2-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1,130-1,186 on human PALB2 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ21816; Partner and localizer of BRCA2
Gene Aliases: BC066140; FANCN; PALB2; PNCA3; RGD1304759
UniProt ID: (Human) Q86YC2, (Mouse) Q3U0P1
Entrez Gene ID: (Human) 79728, (Rat) 293452, (Mouse) 233826
double-strand break repair via homologous recombination
somitogenesis
inner cell mass cell proliferation
mesoderm development
biological_process
organ morphogenesis
post-anal tail morphogenesis
negative regulation of apoptotic process
in utero embryonic development
DNA repair
DNA recombination
cellular response to DNA damage stimulus
chromosome breakage
multicellular organism growth
embryonic organ development
DNA synthesis involved in DNA repair
strand displacement
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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