Product References
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Journal of pharmaceutical analysis
Zhao Y,Wang Y,Wu Y,Tao C,Xu R,Chen Y,Qian L,Xu T,Lian X
Wed Feb 01 00:00:00 EST 2023
Metabolic reprogramming of cancer-associated fibroblasts in pancreatic cancer contributes to the intratumor heterogeneity of PET-CT.
Computational and structural biotechnology journal
Meng Q,Fang Z,Mao X,Tang R,Liang C,Hua J,Wang W,Shi S,Yu X,Xu J
Tue May 09 00:00:00 EDT 2023
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Communications biology
Tan J,Wang W,Liu X,Xu J,Che Y,Liu Y,Hu J,Hu L,Li J,Zhou Q
Mon Jun 05 00:00:00 EDT 2023
YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway.
Frontiers in pharmacology
Li X,Ma TK,Wang M,Zhang XD,Liu TY,Liu Y,Huang ZH,Zhu YH,Zhang S,Yin L,Xu YY,Ding H,Liu C,Shi H,Fan QL
Tue Mar 07 00:00:00 EST 2023
NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling.
BMC cancer
Ma S,Chen Y,Quan P,Zhang J,Han S,Wang G,Qi R,Zhang X,Wang F,Yuan J,Yang X,Jia W,Qin W
Tue Mar 28 00:00:00 EDT 2023
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Yang J,Bao S,Luo S,Jiang L,Li Q,Kong Y,Cao J
Wed Mar 01 00:00:00 EST 2023
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Experimental cell research
Lai X,Liang Y,Jin J,Zhang H,Wu Z,Li G,Wang J,Zhang Z,Chen H,Zeng F,Deng F
Sun Jan 01 00:00:00 EST 2023
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Experimental cell research
Lai X,Liang Y,Jin J,Zhang H,Wu Z,Li G,Wang J,Zhang Z,Chen H,Zeng F,Deng F
Sun Jan 01 00:00:00 EST 2023
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Experimental cell research
Lai X,Liang Y,Jin J,Zhang H,Wu Z,Li G,Wang J,Zhang Z,Chen H,Zeng F,Deng F
Sun Jan 01 00:00:00 EST 2023
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4.
Chemico-biological interactions
Luo S,Zhang C,Gao Z,Jiang L,Li Q,Shi X,Kong Y,Cao J
Thu Jan 05 00:00:00 EST 2023
mTOR inhibitor, gemcitabine and PD-L1 antibody blockade combination therapy suppresses pancreatic cancer progression via metabolic reprogramming and immune microenvironment remodeling in Trp53flox/+LSL-KrasG12D/+Pdx-1-Cre murine models.
Cancer letters
Qiu J,Feng M,Yang G,Cao Z,Liu Y,You L,Zhang T
Wed Feb 01 00:00:00 EST 2023
Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.
Cancer cell
Li G,Choi JE,Kryczek I,Sun Y,Liao P,Li S,Wei S,Grove S,Vatan L,Nelson R,Schaefer G,Allen SG,Sankar K,Fecher LA,Mendiratta-Lala M,Frankel TL,Qin A,Waninger JJ,Tezel A,Alva A,Lao CD,Ramnath N,Cieslik M,Harms PW,Green MD,Chinnaiyan AM,Zou W
Mon Feb 13 00:00:00 EST 2023
DEHP mediates drug resistance by metabolic reprogramming in colorectal cancer cells.
Environmental science and pollution research international
Wu Y,Lu R,Lin Y,Wang J,Lou Z,Zheng X,Zhang L,Pan R,Lu G,Fang Q
Sat Apr 01 00:00:00 EDT 2023
Pseudogene TDGF1P3 regulates the proliferation and metastasis of colorectal cancer cells via the miR-338-3p-PKM2 axis.
Biochemical and biophysical research communications
Ni Q,An M,Luo S,Li X,He G,Shen M,Xu L,Huang J,Yan M,Fan Y,Gao Z
Sun Jan 01 00:00:00 EST 2023
Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208.
Cell death & disease
Han J,Chen X,Wang J,Liu B
Fri Feb 03 00:00:00 EST 2023
Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation.
Pharmaceutical biology
Shen MY,Di YX,Wang X,Tian FX,Zhang MF,Qian FY,Jiang BP,Zhou XP,Zhou LL
Fri Dec 01 00:00:00 EST 2023
Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation.
Pharmaceutical biology
Shen MY,Di YX,Wang X,Tian FX,Zhang MF,Qian FY,Jiang BP,Zhou XP,Zhou LL
Fri Dec 01 00:00:00 EST 2023
Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC.
Molecular carcinogenesis
Fan L,Xia P,Wang J,Xu S,Qiu Z,Wu Y,Feng M,Zhao Q,Wang H,Li X
Thu Jun 01 00:00:00 EDT 2023
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Molecular carcinogenesis
Ma Y,Zhang X,Han X,Hao Z,Ji R,Li J,Guo W,Zhang Y,Guan F,Ma S
Thu Jun 01 00:00:00 EDT 2023
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Huang X,Gao L,Deng R,Peng Y,Wu S,Lu J,Liu X
Tue Aug 01 00:00:00 EDT 2023
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Huang X,Gao L,Deng R,Peng Y,Wu S,Lu J,Liu X
Tue Aug 01 00:00:00 EDT 2023
PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy.
Biomaterials
Wang L,Fu B,Hou DY,Lv YL,Yang G,Li C,Shen JC,Kong B,Zheng LB,Qiu Y,Wang HL,Liu C,Zhang JJ,Bai SY,Li LL,Wang H,Xu WH
Mon May 01 00:00:00 EDT 2023
PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy.
Biomaterials
Wang L,Fu B,Hou DY,Lv YL,Yang G,Li C,Shen JC,Kong B,Zheng LB,Qiu Y,Wang HL,Liu C,Zhang JJ,Bai SY,Li LL,Wang H,Xu WH
Mon May 01 00:00:00 EDT 2023
PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy.
Biomaterials
Wang L,Fu B,Hou DY,Lv YL,Yang G,Li C,Shen JC,Kong B,Zheng LB,Qiu Y,Wang HL,Liu C,Zhang JJ,Bai SY,Li LL,Wang H,Xu WH
Mon May 01 00:00:00 EDT 2023
PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy.
Biomaterials
Wang L,Fu B,Hou DY,Lv YL,Yang G,Li C,Shen JC,Kong B,Zheng LB,Qiu Y,Wang HL,Liu C,Zhang JJ,Bai SY,Li LL,Wang H,Xu WH
Mon May 01 00:00:00 EDT 2023
Hsa_circ_0057104, by competitive adsorption of miR-627-5p, mediates CCND2 expression to promote malignant proliferation and Warburg effect of colorectal cancer.
Biotechnology & genetic engineering reviews
Zhang L,Xu J,Jiang D,Zhang J,Li H,Zhao Z,Mei Z
Tue May 02 00:00:00 EDT 2023
Shoutai Wan regulates glycolysis imbalance at the maternal-fetal interface in threatened abortion mice.
Journal of ethnopharmacology
Zhang L,Wang S,Ma Y,Song Y,Li D,Liang X,Hao Y,Jiang M,Lv J,Du H
Thu Aug 10 00:00:00 EDT 2023
Shoutai Wan regulates glycolysis imbalance at the maternal-fetal interface in threatened abortion mice.
Journal of ethnopharmacology
Zhang L,Wang S,Ma Y,Song Y,Li D,Liang X,Hao Y,Jiang M,Lv J,Du H
Thu Aug 10 00:00:00 EDT 2023
ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.
Developmental cell
Yi J,Wang L,Du J,Wang M,Shen H,Liu Z,Qin Y,Liu J,Hu G,Xiao R,Ding J,Chen X,Wang H,Huang H,Ouyang G,Liu W
Mon May 08 00:00:00 EDT 2023
Changes in the Expression of MIF and Other Key Enzymes of Energy Metabolism in the Myocardia of Broiler Chickens with Ascites Syndrome.
Animals : an open access journal from MDPI
Li L,Jia Q,Chen L,Wang W
Tue Sep 20 00:00:00 EDT 2022
Effects of Glycolysis-Related Genes on Prognosis and the Tumor Microenvironment of Hepatocellular Carcinoma.
Frontiers in pharmacology
Zheng JY,Liu JY,Zhu T,Liu C,Gao Y,Dai WT,Zhuo W,Mao XY,He BM,Liu ZQ
Fri Aug 05 00:00:00 EDT 2022
lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization.
Research (Washington, D.C.)
Zhao K,Wang X,Zhao D,Lin Q,Zhang Y,Hu Y
Tue Aug 02 00:00:00 EDT 2022
Downregulation of HSPA12A underlies myotoxicity of local anesthetic agent bupivacaine through inhibiting PGC1α-mediated mitochondrial integrity.
Toxicology and applied pharmacology
Mao Q,Yu W,Liu S,Cao X,Dai Y,Zhang X,Min X,Liu L,Ding Z
Sat Jan 01 00:00:00 EST 2022
PT109, a novel multi-kinase inhibitor suppresses glioblastoma multiforme through cell reprogramming: Involvement of PTBP1/PKM1/2 pathway.
European journal of pharmacology
Yang Y,Tu Y,Lu J,Chen Q,Zhu Z,Peng W,Zhu W,Wen S,Zhang J,Yin W,Pi R
Tue Apr 05 00:00:00 EDT 2022
The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
Molecular cell
Zhu Y,Jin L,Shi R,Li J,Wang Y,Zhang L,Liang CZ,Narayana VK,De Souza DP,Thorne RF,Zhang LR,Zhang XD,Wu M
Thu Feb 03 00:00:00 EST 2022
The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
Molecular cell
Zhu Y,Jin L,Shi R,Li J,Wang Y,Zhang L,Liang CZ,Narayana VK,De Souza DP,Thorne RF,Zhang LR,Zhang XD,Wu M
Thu Feb 03 00:00:00 EST 2022
The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis.
International journal of molecular sciences
Cui K,Wu H,Fan J,Zhang L,Li H,Guo H,Yang R,Li Z
Tue Oct 11 00:00:00 EDT 2022
PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang C,Tang Q,Xia H,Xu H,Bi F
Sat Jan 01 00:00:00 EST 2022
PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang C,Tang Q,Xia H,Xu H,Bi F
Sat Jan 01 00:00:00 EST 2022
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
Experimental cell research
Ge Y,Zhao R,Li B,Xiao B,Zhou L,Zuo S
Thu Dec 15 00:00:00 EST 2022
Proteomic profiling of plasma exosomes reveals CD82 involvement in the development of esophageal squamous cell carcinoma.
Journal of proteomics
Yang L,Salai A,Sun X,Liu Q,Liu T,Zhang Q,Tuerxun A,Tan Y,Zheng S,Lu X
Mon Aug 15 00:00:00 EDT 2022
Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra-coronary aortic banding.
Acta physiologica (Oxford, England)
Xiong PY,Motamed M,Chen KH,Dasgupta A,Potus F,Tian L,Martin A,Mewburn J,Jones O,Thébaud A,Archer SL
Tue Feb 01 00:00:00 EST 2022
Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra-coronary aortic banding.
Acta physiologica (Oxford, England)
Xiong PY,Motamed M,Chen KH,Dasgupta A,Potus F,Tian L,Martin A,Mewburn J,Jones O,Thébaud A,Archer SL
Tue Feb 01 00:00:00 EST 2022
Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Gao J,Yao M,Zhang W,Yang B,Yuan G,Liu JX,Zhang Y
Tue Nov 01 00:00:00 EDT 2022
Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1.
European journal of pharmacology
Zheng X,Pan Y,Yang G,Liu Y,Zou J,Zhao H,Yin G,Wu Y,Li X,Wei Z,Yu S,Zhao Y,Wang A,Chen W,Lu Y
Thu Sep 15 00:00:00 EDT 2022
Triptolide inhibits Th17 differentiation via controlling PKM2-mediated glycolysis in rheumatoid arthritis.
Immunopharmacology and immunotoxicology
Shen MY,Wang X,Di YX,Zhang MF,Tian FX,Qian FY,Jiang BP,Zhou LL
Thu Dec 01 00:00:00 EST 2022
Nutritional deficiency induces nucleus pulposus cell apoptosis via the ATF4-PKM2-AKT signal ¿axis.
BMC musculoskeletal disorders
Zhou N,Shen B,Bai C,Ma L,Wang S,Wu D
Wed Nov 02 00:00:00 EDT 2022
Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy.
Pharmacological research
Luo L,Luo J,Cai Y,Fu M,Li W,Shi L,Liu J,Dong R,Xu X,Tu L,Yang Y
Thu Sep 01 00:00:00 EDT 2022
The WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders.
International journal of molecular sciences
Baryła I,Styczeń-Binkowska E,Płuciennik E,Kośla K,Bednarek AK
Sat Mar 19 00:00:00 EDT 2022
Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity.
Frontiers in oncology
Wang R,Li J,Zhang C,Guan X,Qin B,Jin R,Qin L,Xu S,Zhang X,Liu R,Ye Q,Cheng L
Sat Jul 16 00:00:00 EDT 2022
Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.
Cancer research
Wang J,Huang Q,Hu X,Zhang S,Jiang Y,Yao G,Hu K,Xu X,Liang B,Wu Q,Ma Z,Wang Y,Wang C,Wu Z,Rong X,Liao W,Shi M
Fri Apr 15 00:00:00 EDT 2022
Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress.
Metabolites
Wang Q,Huang Y,Li Y,Zhang L,Tang H,Zhang J,Cheng G,Zhao M,Lu T,Zhang Q,Luo P,Zhu Y,Xia F,Zhang Y,Liu D,Wang C,Li H,Qiu C,Wang J,Guo Q
Thu Nov 17 00:00:00 EST 2022
Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.
Oncology letters
Qi H,Chen Z,Qin Y,Wang X,Zhang Z,Li Y
Wed Jun 01 00:00:00 EDT 2022
Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis.
International journal of molecular sciences
Wu H,Du J,Li C,Li H,Guo H,Li Z
Thu Mar 24 00:00:00 EDT 2022
Long non-coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR-326/PKM2 axis.
The journal of gene medicine
Wang Y,Yang F,Peng Q,Mei K,He H,Yang Q
Mon Aug 01 00:00:00 EDT 2022
Berberine Modulates Macrophage Activation by Inducing Glycolysis.
Journal of immunology (Baltimore, Md. : 1950)
Li M,Zhang H,Zhang Y,Fan J,Zhu J,Gu X,Li Z,Zhang C,Liu Z,Li Y,Zang M,Jin G,Li G,Mi Y
Sun May 15 00:00:00 EDT 2022
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
Cell biology and toxicology
Li X,Zhang Y,Wang X,Lin F,Cheng X,Wang Z,Wang X
Thu Dec 01 00:00:00 EST 2022
HMGA2 mediates Cr (VI)-induced metabolic reprogramming through binding to mitochondrial D-Loop region.
Ecotoxicology and environmental safety
Bao S,Zhang C,Luo S,Jiang L,Li Q,Kong Y,Cao J
Sat Oct 01 00:00:00 EDT 2022
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Molecular nutrition & food research
Huang L,He C,Zheng S,Wu C,Ren M,Shan Y
Tue Feb 01 00:00:00 EST 2022
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Molecular nutrition & food research
Huang L,He C,Zheng S,Wu C,Ren M,Shan Y
Tue Feb 01 00:00:00 EST 2022
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Molecular nutrition & food research
Huang L,He C,Zheng S,Wu C,Ren M,Shan Y
Tue Feb 01 00:00:00 EST 2022
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Molecular nutrition & food research
Huang L,He C,Zheng S,Wu C,Ren M,Shan Y
Tue Feb 01 00:00:00 EST 2022
MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer.
Non-coding RNA
Miglietta S,Girolimetti G,Marchio L,Sollazzo M,Laprovitera N,Coluccelli S,De Biase D,De Leo A,Santini D,Kurelac I,Iommarini L,Ghelli A,Campana D,Ferracin M,Perrone AM,Gasparre G,Porcelli AM
Sun Sep 25 00:00:00 EDT 2022
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.
Acta pharmacologica Sinica
Xu L,Yang TY,Zhou YW,Wu MF,Shen J,Cheng JL,Liu QX,Cao SY,Wang JQ,Zhang L
Tue Feb 01 00:00:00 EST 2022
Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4-dependent manner.
Cell stress & chaperones
Min X,Cheng H,Cao X,Chen Z,Zhang X,Li Y,Mao Q,Xue B,Fang L,Liu L,Ding Z
Sat Jan 01 00:00:00 EST 2022
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.
Cell chemical biology
Zhang Q,Luo P,Xia F,Tang H,Chen J,Zhang J,Liu D,Zhu Y,Liu Y,Gu L,Zheng L,Li Z,Yang F,Dai L,Liao F,Xu C,Wang J
Thu Aug 18 00:00:00 EDT 2022
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.
Cell chemical biology
Zhang Q,Luo P,Xia F,Tang H,Chen J,Zhang J,Liu D,Zhu Y,Liu Y,Gu L,Zheng L,Li Z,Yang F,Dai L,Liao F,Xu C,Wang J
Thu Aug 18 00:00:00 EDT 2022
Shoutai Wan Improves Embryo Survival by Regulating Aerobic Glycolysis of Trophoblast Cells in a Mouse Model of Recurrent Spontaneous Abortion.
Evidence-based complementary and alternative medicine : eCAM
Liang X,Tang S,Li D,Song Y,He M,Duan Y,Du H
Tue Oct 11 00:00:00 EDT 2022
Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS.
Journal of inflammation research
Yuan Y,Wang W,Zhang Y,Hong Q,Huang W,Li L,Xie Z,Chen Y,Li X,Meng Y
Fri Apr 08 00:00:00 EDT 2022
Long noncoding RNA CERS6-AS1 modulates glucose metabolism and tumor progression in hepatocellular carcinoma by promoting the MDM2/p53 signaling pathway.
Cell death discovery
Xu B,Wei Y,Liu F,Li L,Zhou S,Peng Y,Li B
Thu Aug 04 00:00:00 EDT 2022
Long noncoding RNA CERS6-AS1 modulates glucose metabolism and tumor progression in hepatocellular carcinoma by promoting the MDM2/p53 signaling pathway.
Cell death discovery
Xu B,Wei Y,Liu F,Li L,Zhou S,Peng Y,Li B
Thu Aug 04 00:00:00 EDT 2022
TRIM35 ubiquitination regulates the expression of PKM2 tetramer and dimer and affects the malignant behaviour of breast cancer by regulating the Warburg effect.
International journal of oncology
Wu H,Guo X,Jiao Y,Wu Z,Lv Q
Thu Dec 01 00:00:00 EST 2022
TRIM35 ubiquitination regulates the expression of PKM2 tetramer and dimer and affects the malignant behaviour of breast cancer by regulating the Warburg effect.
International journal of oncology
Wu H,Guo X,Jiao Y,Wu Z,Lv Q
Thu Dec 01 00:00:00 EST 2022
TRIM35 ubiquitination regulates the expression of PKM2 tetramer and dimer and affects the malignant behaviour of breast cancer by regulating the Warburg effect.
International journal of oncology
Wu H,Guo X,Jiao Y,Wu Z,Lv Q
Thu Dec 01 00:00:00 EST 2022
Glucose consumption of vascular cell types in culture: toward optimization of experimental conditions.
American journal of physiology. Cell physiology
Torimoto K,Okuno K,Kuroda R,Shanas N,Cicalese SM,Eguchi K,Elliott KJ,Kawai T,Corbett CB,Peluzzo AM,St Paul AK,Autieri MV,Scalia R,Rizzo V,Hashimoto T,Eguchi S
Sat Jan 01 00:00:00 EST 2022
Glycometabolic reprogramming-mediated proangiogenic phenotype enhancement of cancer-associated fibroblasts in oral squamous cell carcinoma: role of PGC-1α/PFKFB3 axis.
British journal of cancer
Li X,Jiang E,Zhao H,Chen Y,Xu Y,Feng C,Li J,Shang Z
Mon Aug 01 00:00:00 EDT 2022
1H-NMR-based metabolomics reveals the biomarker panel and molecular mechanism of hepatocellular carcinoma progression.
Analytical and bioanalytical chemistry
Wang KX,Du GH,Qin XM,Gao L
Tue Feb 01 00:00:00 EST 2022
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
Biochemical pharmacology
Li M,Chen X,Wang X,Wei X,Wang D,Liu X,Xu L,Batu W,Li Y,Guo B,Zhang L
Fri Oct 01 00:00:00 EDT 2021
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
Frontiers in pharmacology
Chen W,Zhang J,Zhong W,Liu Y,Lu Y,Zeng Z,Huang H,Wan X,Meng X,Zou F,Cai S,Dong H
Tue Oct 05 00:00:00 EDT 2021
Transcriptional dysregulation of TRIM29 promotes colorectal cancer carcinogenesis via pyruvate kinase-mediated glucose metabolism.
Aging
Han J,Zhao Z,Zhang N,Yang Y,Ma L,Feng L,Zhang X,Zuo J,Fan Z,Wang Y,Song Y,Wang G
Wed Jan 20 00:00:00 EST 2021
Sorafenib-Induced Autophagy Promotes Glycolysis by Upregulating the p62/HDAC6/HSP90 Axis in Hepatocellular Carcinoma Cells.
Frontiers in pharmacology
Yan X,Tian R,Sun J,Zhao Y,Liu B,Su J,Li M,Sun W,Xu X
Tue Mar 08 00:00:00 EST 2022
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Frontiers in oncology
Dong Q,Li Q,Duan L,Yin H,Wang X,Liu Y,Wang B,Li K,Yao X,Yuan G,Pan Y
Tue Nov 07 00:00:00 EST 2023
Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial-Mesenchymal Transition.
Frontiers in cell and developmental biology
Zou J,Huang R,Chen Y,Huang X,Li H,Liang P,Chen S
Mon Apr 25 00:00:00 EDT 2022
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
Journal of agricultural and food chemistry
Wu H,Cui M,Li C,Li H,Dai Y,Cui K,Li Z
Wed Mar 17 00:00:00 EDT 2021
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Frontiers in pharmacology
Gao M,Yang J,Gong H,Lin Y,Liu J
Wed Nov 10 00:00:00 EST 2021
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Frontiers in pharmacology
Gao M,Yang J,Gong H,Lin Y,Liu J
Wed Nov 10 00:00:00 EST 2021
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Frontiers in pharmacology
Gao M,Yang J,Gong H,Lin Y,Liu J
Wed Nov 10 00:00:00 EST 2021
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Frontiers in pharmacology
Gao M,Yang J,Gong H,Lin Y,Liu J
Wed Nov 10 00:00:00 EST 2021
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy.
Journal of controlled release : official journal of the Controlled Release Society
Yang J,Ma S,Xu R,Wei Y,Zhang J,Zuo T,Wang Z,Deng H,Yang N,Shen Q
Thu Jun 10 00:00:00 EDT 2021
Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy.
Frontiers in oncology
Qian L,Li Y,Cao Y,Meng G,Peng J,Li H,Wang Y,Xu T,Zhang L,Sun B,Li B,Yu D
Wed Apr 27 00:00:00 EDT 2022
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Toxicology
Mei J,Dlamini MB,Gao Z,Jiang L,Li Q,Geng C,Shi X,Liu Y,Kong Y,Cao J
Fri Oct 01 00:00:00 EDT 2021
Differential localization patterns of pyruvate kinase isoforms in murine naïve, formative, and primed pluripotent states.
Experimental cell research
Dierolf JG,Watson AJ,Betts DH
Sun Aug 15 00:00:00 EDT 2021
Differential localization patterns of pyruvate kinase isoforms in murine naïve, formative, and primed pluripotent states.
Experimental cell research
Dierolf JG,Watson AJ,Betts DH
Sun Aug 15 00:00:00 EDT 2021
Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo.
Cell proliferation
Lin J,Wu S,Shen Q,Liu J,Huang S,Peng G,Qiao Y
Sun Aug 01 00:00:00 EDT 2021
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Frontiers in oncology
Sun Q,Yuan M,Wang H,Zhang X,Zhang R,Wang H,Chen X,Zhu M,Liu S,Wu J
Fri Apr 29 00:00:00 EDT 2022
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Frontiers in oncology
Sun Q,Yuan M,Wang H,Zhang X,Zhang R,Wang H,Chen X,Zhu M,Liu S,Wu J
Fri Apr 29 00:00:00 EDT 2022
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Frontiers in oncology
Sun Q,Yuan M,Wang H,Zhang X,Zhang R,Wang H,Chen X,Zhu M,Liu S,Wu J
Fri Apr 29 00:00:00 EDT 2022
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Frontiers in oncology
Sun Q,Yuan M,Wang H,Zhang X,Zhang R,Wang H,Chen X,Zhu M,Liu S,Wu J
Fri Apr 29 00:00:00 EDT 2022
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Frontiers in oncology
Sun Q,Yuan M,Wang H,Zhang X,Zhang R,Wang H,Chen X,Zhu M,Liu S,Wu J
Fri Apr 29 00:00:00 EDT 2022
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Frontiers in oncology
Sun Q,Yuan M,Wang H,Zhang X,Zhang R,Wang H,Chen X,Zhu M,Liu S,Wu J
Fri Apr 29 00:00:00 EDT 2022
MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis.
Frontiers in oncology
Zhang D,He Z,Shen Y,Wang J,Liu T,Jiang J
Thu Apr 28 00:00:00 EDT 2022
MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis.
Frontiers in oncology
Zhang D,He Z,Shen Y,Wang J,Liu T,Jiang J
Thu Apr 28 00:00:00 EDT 2022
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Journal of medicinal chemistry
Liu X,Wang C,Li S,Qu L,Yin F,Lu D,Luo H,Chen X,Luo Z,Cui N,Wang X,Kong L
Thu Dec 09 00:00:00 EST 2021
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Journal of medicinal chemistry
Liu X,Wang C,Li S,Qu L,Yin F,Lu D,Luo H,Chen X,Luo Z,Cui N,Wang X,Kong L
Thu Dec 09 00:00:00 EST 2021
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
The international journal of biochemistry & cell biology
Xu Z,Hu H,Fang D,Wang J,Zhao K
Sun Aug 01 00:00:00 EDT 2021
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway.
Journal of neuroinflammation
Lu L,Wang H,Liu X,Tan L,Qiao X,Ni J,Sun Y,Liang J,Hou Y,Dou H
Wed Oct 13 00:00:00 EDT 2021
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway.
Journal of neuroinflammation
Lu L,Wang H,Liu X,Tan L,Qiao X,Ni J,Sun Y,Liang J,Hou Y,Dou H
Wed Oct 13 00:00:00 EDT 2021
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Molecular oncology
Sun T,Liu Z,Bi F,Yang Q
Wed Dec 01 00:00:00 EST 2021
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Molecular oncology
Sun T,Liu Z,Bi F,Yang Q
Wed Dec 01 00:00:00 EST 2021
EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.
Mediators of inflammation
Ni S,Yang B,Xia L,Zhang H
Wed Dec 22 00:00:00 EST 2021
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
EMBO reports
Wu Z,Zuo M,Zeng L,Cui K,Liu B,Yan C,Chen L,Dong J,Shangguan F,Hu W,He H,Lu B,Song Z
Thu Jan 07 00:00:00 EST 2021
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Fitoterapia
Pei L,Le Y,Chen H,Feng J,Liu Z,Zhu J,Wang C,Chen L,Dou X,Lu D
Thu Jul 01 00:00:00 EDT 2021
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Fitoterapia
Pei L,Le Y,Chen H,Feng J,Liu Z,Zhu J,Wang C,Chen L,Dou X,Lu D
Thu Jul 01 00:00:00 EDT 2021
Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis.
Frontiers in nutrition
Lu X,Qiao S,Peng C,Yan W,Xu Z,Qu J,Hou Y,Zhao S,Chen P,Wang T
Tue Dec 07 00:00:00 EST 2021
Plasma‑derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
Oncology reports
Yang L,Zheng S,Liu Q,Liu T,Zhang Q,Han X,Tuerxun A,Lu X
Fri Oct 01 00:00:00 EDT 2021
Plasma‑derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
Oncology reports
Yang L,Zheng S,Liu Q,Liu T,Zhang Q,Han X,Tuerxun A,Lu X
Fri Oct 01 00:00:00 EDT 2021
Plasma‑derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
Oncology reports
Yang L,Zheng S,Liu Q,Liu T,Zhang Q,Han X,Tuerxun A,Lu X
Fri Oct 01 00:00:00 EDT 2021
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Nature communications
Wang C,Li Y,Yan S,Wang H,Shao X,Xiao M,Yang B,Qin G,Kong R,Chen R,Zhang N
Mon Jun 22 00:00:00 EDT 2020
Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Journal of cellular and molecular medicine
Li M,Shao J,Guo Z,Jin C,Wang L,Wang F,Jia Y,Zhu Z,Zhang Z,Zhang F,Zheng S,Wang X
Sun Mar 01 00:00:00 EST 2020
Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Journal of cellular and molecular medicine
Li M,Shao J,Guo Z,Jin C,Wang L,Wang F,Jia Y,Zhu Z,Zhang Z,Zhang F,Zheng S,Wang X
Sun Mar 01 00:00:00 EST 2020
Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism.
Environmental pollution (Barking, Essex : 1987)
Zhang Z,Su H,Ahmed RZ,Zheng Y,Jin X
Tue Sep 01 00:00:00 EDT 2020
Cadmium inhibits apoptosis of human esophageal epithelial cells by upregulating CDK6.
Ecotoxicology and environmental safety
Yang J,Guo T,Liang X,Zhai Y,Cheng Y,Sun H,Cui Y,Cheng X
Tue Dec 01 00:00:00 EST 2020
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Biochemical pharmacology
Deng X,Zhao J,Qu L,Duan Z,Fu R,Zhu C,Fan D
Sat Aug 01 00:00:00 EDT 2020
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Biochemical pharmacology
Deng X,Zhao J,Qu L,Duan Z,Fu R,Zhu C,Fan D
Sat Aug 01 00:00:00 EDT 2020
Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer.
Frontiers in oncology
Du Y,Wei N,Ma R,Jiang SH,Song D
Tue Apr 19 00:00:00 EDT 2022
PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition.
Analytical cellular pathology (Amsterdam)
Xiao H,Zhang L,Chen Y,Zhou C,Wang X,Wang D,Liu Z
Thu Aug 26 00:00:00 EDT 2021
AT1-receptor autoantibody exposure in utero contributes to cardiac dysfunction and increased glycolysis in fetal mice.
Acta biochimica et biophysica Sinica
Bai L,Wang M,Zhang S,Yue M,Guo Y,Wang P,Liu H
Tue Dec 29 00:00:00 EST 2020
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Theranostics
Hua Q,Mi B,Xu F,Wen J,Zhao L,Liu J,Huang G
Thu May 13 00:00:00 EDT 2021
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Theranostics
Hua Q,Mi B,Xu F,Wen J,Zhao L,Liu J,Huang G
Thu May 13 00:00:00 EDT 2021
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Theranostics
Hua Q,Mi B,Xu F,Wen J,Zhao L,Liu J,Huang G
Thu May 13 00:00:00 EDT 2021
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Theranostics
Hua Q,Mi B,Xu F,Wen J,Zhao L,Liu J,Huang G
Thu May 13 00:00:00 EDT 2021
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Theranostics
Hua Q,Mi B,Xu F,Wen J,Zhao L,Liu J,Huang G
Thu May 13 00:00:00 EDT 2021
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
American journal of translational research
Chen L,Peng J,Wang Y,Jiang H,Wang W,Dai J,Tang M,Wei Y,Kuang H,Xu G,Xu H,Zhou F
Mon Sep 28 00:00:00 EDT 2020
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Toxicology letters
Gao Z,Dlamini MB,Ge H,Jiang L,Geng C,Li Q,Shi X,Liu Y,Cao J
Thu Oct 01 00:00:00 EDT 2020
Platelet-rich plasma improves chronic inflammatory pain by inhibiting PKM2-mediated aerobic glycolysis in astrocytes.
Annals of translational medicine
Wei X,Jin XH,Meng XW,Hua J,Ji FH,Wang LN,Yang JP
Sun Nov 01 00:00:00 EDT 2020
Platelet-rich plasma improves chronic inflammatory pain by inhibiting PKM2-mediated aerobic glycolysis in astrocytes.
Annals of translational medicine
Wei X,Jin XH,Meng XW,Hua J,Ji FH,Wang LN,Yang JP
Sun Nov 01 00:00:00 EDT 2020
A glycolysis-based 4-mRNA signature correlates with the prognosis and cell cycle process in patients with bladder cancer.
Cancer cell international
Zhang C,Gou X,He W,Yang H,Yin H
Thu Apr 14 00:00:00 EDT 2022
E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
Theranostics
Chen D,Wang Y,Lu R,Jiang X,Chen X,Meng N,Chen M,Xie S,Yan GR
Wed May 19 00:00:00 EDT 2021
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes.
BMC molecular and cell biology
Jiang Y,Gu Y,Xu H,Tian X,Zhang X,Xu X,Yan W,Zhang X
Fri Jun 19 00:00:00 EDT 2020
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Life sciences
Dong D,Dong Y,Fu J,Lu S,Yuan C,Xia M,Sun L
Sat Aug 15 00:00:00 EDT 2020
Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells.
OncoTargets and therapy
Yuan Q,Yu H,Chen J,Song X,Sun L
Wed Apr 13 00:00:00 EDT 2022
Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells.
OncoTargets and therapy
Yuan Q,Yu H,Chen J,Song X,Sun L
Wed Apr 13 00:00:00 EDT 2022
Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells.
OncoTargets and therapy
Yuan Q,Yu H,Chen J,Song X,Sun L
Wed Apr 13 00:00:00 EDT 2022
Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells.
OncoTargets and therapy
Yuan Q,Yu H,Chen J,Song X,Sun L
Wed Apr 13 00:00:00 EDT 2022
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
Bioorganic chemistry
Liu R,Deng X,Peng Y,Feng W,Xiong R,Zou Y,Lei X,Zheng X,Xie Z,Tang G
Sun Mar 01 00:00:00 EST 2020
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
Oncology reports
Zhang X,Liu T,Zheng S,Liu Q,Shen T,Han X,Zhang Q,Yang L,Lu X
Thu Oct 01 00:00:00 EDT 2020
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
Oncology reports
Zhang X,Liu T,Zheng S,Liu Q,Shen T,Han X,Zhang Q,Yang L,Lu X
Thu Oct 01 00:00:00 EDT 2020
Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells.
OncoTargets and therapy
Zeng Z,Lan J,Lei S,Yang Y,He Z,Xue Y,Chen T
Mon Apr 18 00:00:00 EDT 2022
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Acta pharmacologica Sinica
Liu BW,Wang TJ,Li LL,Zhang L,Liu YX,Feng JY,Wu Y,Xu FF,Zhang QS,Bao MZ,Zhang WY,Ye LH
Mon Apr 01 00:00:00 EDT 2019
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Acta pharmacologica Sinica
Liu BW,Wang TJ,Li LL,Zhang L,Liu YX,Feng JY,Wu Y,Xu FF,Zhang QS,Bao MZ,Zhang WY,Ye LH
Mon Apr 01 00:00:00 EDT 2019
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Acta pharmacologica Sinica
Liu BW,Wang TJ,Li LL,Zhang L,Liu YX,Feng JY,Wu Y,Xu FF,Zhang QS,Bao MZ,Zhang WY,Ye LH
Mon Apr 01 00:00:00 EDT 2019
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Acta pharmacologica Sinica
Liu BW,Wang TJ,Li LL,Zhang L,Liu YX,Feng JY,Wu Y,Xu FF,Zhang QS,Bao MZ,Zhang WY,Ye LH
Mon Apr 01 00:00:00 EDT 2019
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Biochemistry and cell biology = Biochimie et biologie cellulaire
Liu B,Jin J,Zhang Z,Zuo L,Jiang M,Xie C
Thu Aug 01 00:00:00 EDT 2019
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Biochemistry and cell biology = Biochimie et biologie cellulaire
Liu B,Jin J,Zhang Z,Zuo L,Jiang M,Xie C
Thu Aug 01 00:00:00 EDT 2019
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Journal of food science
Chai XX,Le YF,Wang JC,Mei CX,Feng JF,Zhao H,Wang C,Lu DZ
Sun Dec 01 00:00:00 EST 2019
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Journal of food science
Chai XX,Le YF,Wang JC,Mei CX,Feng JF,Zhao H,Wang C,Lu DZ
Sun Dec 01 00:00:00 EST 2019
Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis.
Journal of Cancer
Ye M,Pang N,Wan T,Huang Y,Wei T,Jiang X,Zhou Y,Huang Y,Yang H,Zhang Z,Yang L
Thu Oct 01 00:00:00 EDT 2020
Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.
Cell communication and signaling : CCS
Wang F,Jia Y,Li M,Wang L,Shao J,Guo Q,Tan S,Ding H,Chen A,Zhang F,Zheng S
Mon Feb 11 00:00:00 EST 2019
TBC1D8 Amplification Drives Tumorigenesis through Metabolism Reprogramming in Ovarian Cancer.
Theranostics
Chen M,Sheng XJ,Qin YY,Zhu S,Wu QX,Jia L,Meng N,He YT,Yan GR
Tue Jan 14 00:00:00 EST 2020
TBC1D8 Amplification Drives Tumorigenesis through Metabolism Reprogramming in Ovarian Cancer.
Theranostics
Chen M,Sheng XJ,Qin YY,Zhu S,Wu QX,Jia L,Meng N,He YT,Yan GR
Tue Jan 14 00:00:00 EST 2020
PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-β1-induced EMT.
Journal of cellular biochemistry
Ma R,Liu Q,Zheng S,Liu T,Tan D,Lu X
Mon Jul 01 00:00:00 EDT 2019
PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-β1-induced EMT.
Journal of cellular biochemistry
Ma R,Liu Q,Zheng S,Liu T,Tan D,Lu X
Mon Jul 01 00:00:00 EDT 2019
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2.
Journal of thoracic disease
Chu X,Xiang M,Feng L,Liu H,Zhou C
Sun Sep 01 00:00:00 EDT 2019
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2.
Journal of thoracic disease
Chu X,Xiang M,Feng L,Liu H,Zhou C
Sun Sep 01 00:00:00 EDT 2019
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Cell reports
Gassaway BM,Cardone RL,Padyana AK,Petersen MC,Judd ET,Hayes S,Tong S,Barber KW,Apostolidi M,Abulizi A,Sheetz JB,Aerni HR,Gross S,Kung C,Samuel VT,Shulman GI,Kibbey RG,Rinehart J
Tue Dec 10 00:00:00 EST 2019
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
Cell death & disease
Zhang W,Shao W,Dong Z,Zhang S,Liu C,Chen S
Tue May 28 00:00:00 EDT 2019
MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma.
Cell proliferation
Chen J,Yu Y,Chen X,He Y,Hu Q,Li H,Han Q,Ren F,Li J,Li C,Bao J,Ren Z,Duan Z,Cui G,Sun R
Sat Dec 01 00:00:00 EST 2018
MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma.
Cell proliferation
Chen J,Yu Y,Chen X,He Y,Hu Q,Li H,Han Q,Ren F,Li J,Li C,Bao J,Ren Z,Duan Z,Cui G,Sun R
Sat Dec 01 00:00:00 EST 2018
MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma.
Cell proliferation
Chen J,Yu Y,Chen X,He Y,Hu Q,Li H,Han Q,Ren F,Li J,Li C,Bao J,Ren Z,Duan Z,Cui G,Sun R
Sat Dec 01 00:00:00 EST 2018
MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma.
Cell proliferation
Chen J,Yu Y,Chen X,He Y,Hu Q,Li H,Han Q,Ren F,Li J,Li C,Bao J,Ren Z,Duan Z,Cui G,Sun R
Sat Dec 01 00:00:00 EST 2018
MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma.
Cell proliferation
Chen J,Yu Y,Chen X,He Y,Hu Q,Li H,Han Q,Ren F,Li J,Li C,Bao J,Ren Z,Duan Z,Cui G,Sun R
Sat Dec 01 00:00:00 EST 2018
Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.
Oxidative medicine and cellular longevity
Yan B,Cheng L,Jiang Z,Chen K,Zhou C,Sun L,Cao J,Qian W,Li J,Shan T,Lei J,Ma Q,Ma J
Mon Oct 01 00:00:00 EDT 2018
Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.
Oxidative medicine and cellular longevity
Yan B,Cheng L,Jiang Z,Chen K,Zhou C,Sun L,Cao J,Qian W,Li J,Shan T,Lei J,Ma Q,Ma J
Mon Oct 01 00:00:00 EDT 2018
Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.
Food & function
Yang P,Ding GB,Liu W,Fu R,Sajid A,Li Z
Wed Nov 14 00:00:00 EST 2018
Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.
Food & function
Yang P,Ding GB,Liu W,Fu R,Sajid A,Li Z
Wed Nov 14 00:00:00 EST 2018
Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Li W,Qiu Y,Hao J,Zhao C,Deng X,Shu G
Thu Nov 01 00:00:00 EDT 2018
Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Li W,Qiu Y,Hao J,Zhao C,Deng X,Shu G
Thu Nov 01 00:00:00 EDT 2018
Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling.
Journal of proteome research
Xing YX,Li MH,Tao L,Ruan LY,Hong W,Chen C,Zhao WL,Xu H,Chen JF,Wang JS
Fri May 04 00:00:00 EDT 2018
Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling.
Journal of proteome research
Xing YX,Li MH,Tao L,Ruan LY,Hong W,Chen C,Zhao WL,Xu H,Chen JF,Wang JS
Fri May 04 00:00:00 EDT 2018
1H Nuclear Magnetic Resonance Based Metabolomics Approach Reveals the Metabolic Mechanism of (-)-5-Hydroxy-equol against Hepatocellular Carcinoma Cells in Vitro.
Journal of proteome research
Gao L,Wang KX,Zhang NN,Li JQ,Qin XM,Wang XL
Fri May 04 00:00:00 EDT 2018
1H Nuclear Magnetic Resonance Based Metabolomics Approach Reveals the Metabolic Mechanism of (-)-5-Hydroxy-equol against Hepatocellular Carcinoma Cells in Vitro.
Journal of proteome research
Gao L,Wang KX,Zhang NN,Li JQ,Qin XM,Wang XL
Fri May 04 00:00:00 EDT 2018
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer.
International journal of molecular medicine
Fan L,Huang C,Li J,Gao T,Lin Z,Yao T
Mon Oct 01 00:00:00 EDT 2018
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer.
International journal of molecular medicine
Fan L,Huang C,Li J,Gao T,Lin Z,Yao T
Mon Oct 01 00:00:00 EDT 2018
Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.
Journal of ethnopharmacology
Wu L,Cao KX,Ni ZH,Li WD,Chen ZP,Cheng HB,Liu X
Fri Aug 10 00:00:00 EDT 2018
Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.
Journal of ethnopharmacology
Wu L,Cao KX,Ni ZH,Li WD,Chen ZP,Cheng HB,Liu X
Fri Aug 10 00:00:00 EDT 2018
Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer.
Anticancer research
Kobierzycki C,Piotrowska A,Latkowski K,Zabel M,Nowak-Markwitz E,Spaczynski M,Kedzia W,Pula B,Podhorska-Okolow M,Dziegiel P
Mon Jan 01 00:00:00 EST 2018
Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer.
Anticancer research
Kobierzycki C,Piotrowska A,Latkowski K,Zabel M,Nowak-Markwitz E,Spaczynski M,Kedzia W,Pula B,Podhorska-Okolow M,Dziegiel P
Mon Jan 01 00:00:00 EST 2018
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Journal of experimental & clinical cancer research : CR
Zhang X,Li Y,Ma Y,Yang L,Wang T,Meng X,Zong Z,Sun X,Hua X,Li H
Tue Sep 04 00:00:00 EDT 2018
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Journal of experimental & clinical cancer research : CR
Zhang X,Li Y,Ma Y,Yang L,Wang T,Meng X,Zong Z,Sun X,Hua X,Li H
Tue Sep 04 00:00:00 EDT 2018
Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.
Frontiers in cardiovascular medicine
Xiong PY,Tian L,Dunham-Snary KJ,Chen KH,Mewburn JD,Neuber-Hess M,Martin A,Dasgupta A,Potus F,Archer SL
Wed Sep 30 00:00:00 EDT 2020
Multiomics Integration Reveals the Landscape of Prometastasis Metabolism in Hepatocellular Carcinoma.
Molecular & cellular proteomics : MCP
Li Y,Zhuang H,Zhang X,Li Y,Liu Y,Yi X,Qin G,Wei W,Chen R
Sun Apr 01 00:00:00 EDT 2018
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
Cell death & disease
Meng Q,Xu J,Liang C,Liu J,Hua J,Zhang Y,Ni Q,Shi S,Yu X
Tue Dec 11 00:00:00 EST 2018
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
Cell death & disease
Meng Q,Xu J,Liang C,Liu J,Hua J,Zhang Y,Ni Q,Shi S,Yu X
Tue Dec 11 00:00:00 EST 2018
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
Clinical and experimental pharmacology & physiology
Wu H,He L,Shi J,Hou X,Zhang H,Zhang X,An Q,Fan F
Sat Dec 01 00:00:00 EST 2018
A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.
Molecular cell
Huang JZ,Chen M,Chen D,Gao XC,Zhu S,Huang H,Hu M,Zhu H,Yan GR
Thu Oct 05 00:00:00 EDT 2017
A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.
Molecular cell
Huang JZ,Chen M,Chen D,Gao XC,Zhu S,Huang H,Hu M,Zhu H,Yan GR
Thu Oct 05 00:00:00 EDT 2017
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
American journal of cancer research
Jing C,Qu X,Li Z,Wu C,Zhao M,Wang Y,Sun S,Zhang S,Chen J,Qiao Y,Hu X,Yao X,Jin R,Wang X,Zhang L,Zhou X
Wed Sep 30 00:00:00 EDT 2020
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
American journal of cancer research
Jing C,Qu X,Li Z,Wu C,Zhao M,Wang Y,Sun S,Zhang S,Chen J,Qiao Y,Hu X,Yao X,Jin R,Wang X,Zhang L,Zhou X
Wed Sep 30 00:00:00 EDT 2020
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
American journal of cancer research
Jing C,Qu X,Li Z,Wu C,Zhao M,Wang Y,Sun S,Zhang S,Chen J,Qiao Y,Hu X,Yao X,Jin R,Wang X,Zhang L,Zhou X
Wed Sep 30 00:00:00 EDT 2020
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
American journal of cancer research
Jing C,Qu X,Li Z,Wu C,Zhao M,Wang Y,Sun S,Zhang S,Chen J,Qiao Y,Hu X,Yao X,Jin R,Wang X,Zhang L,Zhou X
Wed Sep 30 00:00:00 EDT 2020
Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells.
Cellular signalling
Horiuchi Y,Nakatsu D,Kano F,Murata M
Sun Oct 01 00:00:00 EDT 2017
Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells.
Cellular signalling
Horiuchi Y,Nakatsu D,Kano F,Murata M
Sun Oct 01 00:00:00 EDT 2017
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
Biochemical and biophysical research communications
Lian X,Zhao J,Wu X,Zhang Y,Li Q,Lin S,Bai XY,Chen X
Sat Jun 24 00:00:00 EDT 2017
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
Biochemical and biophysical research communications
Lian X,Zhao J,Wu X,Zhang Y,Li Q,Lin S,Bai XY,Chen X
Sat Jun 24 00:00:00 EDT 2017
Dahuang Zhechong Pill Combined with Doxorubicin Induces Cell Death through Regulating Energy Metabolism in Human Hepatocellular Carcinoma Cells.
Evidence-based complementary and alternative medicine : eCAM
Wu L,Zhao J,Cai H,Wang J,Chen Z,Li W,Liu X
Thu Oct 01 00:00:00 EDT 2020
Dahuang Zhechong Pill Combined with Doxorubicin Induces Cell Death through Regulating Energy Metabolism in Human Hepatocellular Carcinoma Cells.
Evidence-based complementary and alternative medicine : eCAM
Wu L,Zhao J,Cai H,Wang J,Chen Z,Li W,Liu X
Thu Oct 01 00:00:00 EDT 2020
Deciphering the protein-protein interaction network regulating hepatocellular carcinoma metastasis.
Biochimica et biophysica acta. Proteins and proteomics
Qin G,Dang M,Gao H,Wang H,Luo F,Chen R
Fri Sep 01 00:00:00 EDT 2017
18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma.
Oncotarget
Huang P,Zhao X,Xiao W,Dong Y,Hu G
Tue Jun 13 00:00:00 EDT 2017
18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma.
Oncotarget
Huang P,Zhao X,Xiao W,Dong Y,Hu G
Tue Jun 13 00:00:00 EDT 2017
MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
American journal of cancer research
Wu H,Li Z,Wang Y,Yang P,Li Z,Li H,Wu C
Thu Oct 01 00:00:00 EDT 2020
MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
American journal of cancer research
Wu H,Li Z,Wang Y,Yang P,Li Z,Li H,Wu C
Thu Oct 01 00:00:00 EDT 2020
MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
American journal of cancer research
Wu H,Li Z,Wang Y,Yang P,Li Z,Li H,Wu C
Thu Oct 01 00:00:00 EDT 2020
MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
American journal of cancer research
Wu H,Li Z,Wang Y,Yang P,Li Z,Li H,Wu C
Thu Oct 01 00:00:00 EDT 2020
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Scientific reports
Lu W,Cao Y,Zhang Y,Li S,Gao J,Wang XA,Mu J,Hu YP,Jiang L,Dong P,Gong W,Liu Y
Fri Jun 10 00:00:00 EDT 2016
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Scientific reports
Lu W,Cao Y,Zhang Y,Li S,Gao J,Wang XA,Mu J,Hu YP,Jiang L,Dong P,Gong W,Liu Y
Fri Jun 10 00:00:00 EDT 2016
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Scientific reports
Lu W,Cao Y,Zhang Y,Li S,Gao J,Wang XA,Mu J,Hu YP,Jiang L,Dong P,Gong W,Liu Y
Fri Jun 10 00:00:00 EDT 2016
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Scientific reports
Lu W,Cao Y,Zhang Y,Li S,Gao J,Wang XA,Mu J,Hu YP,Jiang L,Dong P,Gong W,Liu Y
Fri Jun 10 00:00:00 EDT 2016
L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.
Proceedings of the National Academy of Sciences of the United States of America
Nakatsu D,Horiuchi Y,Kano F,Noguchi Y,Sugawara T,Takamoto I,Kubota N,Kadowaki T,Murata M
Tue Mar 10 00:00:00 EDT 2015
L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.
Proceedings of the National Academy of Sciences of the United States of America
Nakatsu D,Horiuchi Y,Kano F,Noguchi Y,Sugawara T,Takamoto I,Kubota N,Kadowaki T,Murata M
Tue Mar 10 00:00:00 EDT 2015
A small subunit processome protein promotes cancer by altering translation.
Oncogene
Yang HW,Kim TM,Song SS,Menon L,Jiang X,Huang W,Black PM,Park PJ,Carroll RS,Johnson MD
Thu Aug 20 00:00:00 EDT 2015
A small subunit processome protein promotes cancer by altering translation.
Oncogene
Yang HW,Kim TM,Song SS,Menon L,Jiang X,Huang W,Black PM,Park PJ,Carroll RS,Johnson MD
Thu Aug 20 00:00:00 EDT 2015
Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species.
PloS one
Cautain B,de Pedro N,Schulz C,Pascual J,Sousa Tda S,Martin J,Pérez-Victoria I,Asensio F,González I,Bills GF,Reyes F,Genilloud O,Vicente F
Wed May 11 00:00:00 EDT 2016
Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species.
PloS one
Cautain B,de Pedro N,Schulz C,Pascual J,Sousa Tda S,Martin J,Pérez-Victoria I,Asensio F,González I,Bills GF,Reyes F,Genilloud O,Vicente F
Wed May 11 00:00:00 EDT 2016
Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.
Regenerative therapy
Konno M,Ishii H,Koseki J,Tanuma N,Nishida N,Kawamoto K,Nishimura T,Nakata A,Matsui H,Noguchi K,Ozaki M,Noguchi Y,Shima H,Gotoh N,Nagano H,Doki Y,Mori M
Mon Jun 01 00:00:00 EDT 2015
Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming.
PloS one
Konno M,Koseki J,Kawamoto K,Nishida N,Matsui H,Dewi DL,Ozaki M,Noguchi Y,Mimori K,Gotoh N,Tanuma N,Shima H,Doki Y,Mori M,Ishii H
Mon Apr 25 00:00:00 EDT 2016
Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming.
PloS one
Konno M,Koseki J,Kawamoto K,Nishida N,Matsui H,Dewi DL,Ozaki M,Noguchi Y,Mimori K,Gotoh N,Tanuma N,Shima H,Doki Y,Mori M,Ishii H
Mon Apr 25 00:00:00 EDT 2016
Estradiol-17β upregulates pyruvate kinase M2 expression to coactivate estrogen receptor-α and to integrate metabolic reprogramming with the mitogenic response in endometrial cells.
The Journal of clinical endocrinology and metabolism
Salama SA,Mohammad MA,Diaz-Arrastia CR,Kamel MW,Kilic GS,Ndofor BT,Abdel-Baki MS,Theiler SK
Wed Oct 01 00:00:00 EDT 2014
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Anticancer research
Kobierzycki C,Pula B,Werynska B,Piotrowska A,Muszczynska-Bernhard B,Dziegiel P,Rakus D
Tue Jul 01 00:00:00 EDT 2014
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Anticancer research
Kobierzycki C,Pula B,Werynska B,Piotrowska A,Muszczynska-Bernhard B,Dziegiel P,Rakus D
Tue Jul 01 00:00:00 EDT 2014
Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome?
Seminars in oncology
Martinez-Outschoorn UE,Whitaker-Menezes D,Valsecchi M,Martinez-Cantarin MP,Dulau-Florea A,Gong J,Howell A,Flomenberg N,Pestell RG,Wagner J,Arana-Yi C,Sharma M,Sotgia F,Lisanti MP
Thu Aug 01 00:00:00 EDT 2013
Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome?
Seminars in oncology
Martinez-Outschoorn UE,Whitaker-Menezes D,Valsecchi M,Martinez-Cantarin MP,Dulau-Florea A,Gong J,Howell A,Flomenberg N,Pestell RG,Wagner J,Arana-Yi C,Sharma M,Sotgia F,Lisanti MP
Thu Aug 01 00:00:00 EDT 2013
A study of PKM2, PFK-1, and ANT1 expressions in cervical biopsy tissues in China.
Medical oncology (Northwood, London, England)
Yuan Y,Guo-Qing P,Yan T,Hong-Lin Y,Gong-Hua H,Cai-Gao Z
Sat Dec 01 00:00:00 EST 2012
A study of PKM2, PFK-1, and ANT1 expressions in cervical biopsy tissues in China.
Medical oncology (Northwood, London, England)
Yuan Y,Guo-Qing P,Yan T,Hong-Lin Y,Gong-Hua H,Cai-Gao Z
Sat Dec 01 00:00:00 EST 2012
A study of PKM2, PFK-1, and ANT1 expressions in cervical biopsy tissues in China.
Medical oncology (Northwood, London, England)
Yuan Y,Guo-Qing P,Yan T,Hong-Lin Y,Gong-Hua H,Cai-Gao Z
Sat Dec 01 00:00:00 EST 2012
A study of PKM2, PFK-1, and ANT1 expressions in cervical biopsy tissues in China.
Medical oncology (Northwood, London, England)
Yuan Y,Guo-Qing P,Yan T,Hong-Lin Y,Gong-Hua H,Cai-Gao Z
Sat Dec 01 00:00:00 EST 2012
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Cancer biology & therapy
Chiavarina B,Whitaker-Menezes D,Martinez-Outschoorn UE,Witkiewicz AK,Birbe R,Howell A,Pestell RG,Smith J,Daniel R,Sotgia F,Lisanti MP
Thu Dec 15 00:00:00 EST 2011
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Cancer biology & therapy
Chiavarina B,Whitaker-Menezes D,Martinez-Outschoorn UE,Witkiewicz AK,Birbe R,Howell A,Pestell RG,Smith J,Daniel R,Sotgia F,Lisanti MP
Thu Dec 15 00:00:00 EST 2011
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Cancer biology & therapy
Chiavarina B,Whitaker-Menezes D,Martinez-Outschoorn UE,Witkiewicz AK,Birbe R,Howell A,Pestell RG,Smith J,Daniel R,Sotgia F,Lisanti MP
Thu Dec 15 00:00:00 EST 2011
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Cancer biology & therapy
Chiavarina B,Whitaker-Menezes D,Martinez-Outschoorn UE,Witkiewicz AK,Birbe R,Howell A,Pestell RG,Smith J,Daniel R,Sotgia F,Lisanti MP
Thu Dec 15 00:00:00 EST 2011
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Cancer biology & therapy
Chiavarina B,Whitaker-Menezes D,Martinez-Outschoorn UE,Witkiewicz AK,Birbe R,Howell A,Pestell RG,Smith J,Daniel R,Sotgia F,Lisanti MP
Thu Dec 15 00:00:00 EST 2011
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Cell cycle (Georgetown, Tex.)
Martinez-Outschoorn UE,Balliet RM,Rivadeneira DB,Chiavarina B,Pavlides S,Wang C,Whitaker-Menezes D,Daumer KM,Lin Z,Witkiewicz AK,Flomenberg N,Howell A,Pestell RG,Knudsen ES,Sotgia F,Lisanti MP
Sun Aug 15 00:00:00 EDT 2010
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Cell cycle (Georgetown, Tex.)
Martinez-Outschoorn UE,Balliet RM,Rivadeneira DB,Chiavarina B,Pavlides S,Wang C,Whitaker-Menezes D,Daumer KM,Lin Z,Witkiewicz AK,Flomenberg N,Howell A,Pestell RG,Knudsen ES,Sotgia F,Lisanti MP
Sun Aug 15 00:00:00 EDT 2010
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Cell cycle (Georgetown, Tex.)
Martinez-Outschoorn UE,Balliet RM,Rivadeneira DB,Chiavarina B,Pavlides S,Wang C,Whitaker-Menezes D,Daumer KM,Lin Z,Witkiewicz AK,Flomenberg N,Howell A,Pestell RG,Knudsen ES,Sotgia F,Lisanti MP
Sun Aug 15 00:00:00 EDT 2010
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Cell cycle (Georgetown, Tex.)
Martinez-Outschoorn UE,Balliet RM,Rivadeneira DB,Chiavarina B,Pavlides S,Wang C,Whitaker-Menezes D,Daumer KM,Lin Z,Witkiewicz AK,Flomenberg N,Howell A,Pestell RG,Knudsen ES,Sotgia F,Lisanti MP
Sun Aug 15 00:00:00 EDT 2010
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Cell cycle (Georgetown, Tex.)
Martinez-Outschoorn UE,Balliet RM,Rivadeneira DB,Chiavarina B,Pavlides S,Wang C,Whitaker-Menezes D,Daumer KM,Lin Z,Witkiewicz AK,Flomenberg N,Howell A,Pestell RG,Knudsen ES,Sotgia F,Lisanti MP
Sun Aug 15 00:00:00 EDT 2010
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Cell cycle (Georgetown, Tex.)
Bonuccelli G,Whitaker-Menezes D,Castello-Cros R,Pavlides S,Pestell RG,Fatatis A,Witkiewicz AK,Vander Heiden MG,Migneco G,Chiavarina B,Frank PG,Capozza F,Flomenberg N,Martinez-Outschoorn UE,Sotgia F,Lisanti MP
Sat May 15 00:00:00 EDT 2010
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Cell cycle (Georgetown, Tex.)
Bonuccelli G,Whitaker-Menezes D,Castello-Cros R,Pavlides S,Pestell RG,Fatatis A,Witkiewicz AK,Vander Heiden MG,Migneco G,Chiavarina B,Frank PG,Capozza F,Flomenberg N,Martinez-Outschoorn UE,Sotgia F,Lisanti MP
Sat May 15 00:00:00 EDT 2010
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Cell cycle (Georgetown, Tex.)
Bonuccelli G,Whitaker-Menezes D,Castello-Cros R,Pavlides S,Pestell RG,Fatatis A,Witkiewicz AK,Vander Heiden MG,Migneco G,Chiavarina B,Frank PG,Capozza F,Flomenberg N,Martinez-Outschoorn UE,Sotgia F,Lisanti MP
Sat May 15 00:00:00 EDT 2010
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Cell cycle (Georgetown, Tex.)
Bonuccelli G,Whitaker-Menezes D,Castello-Cros R,Pavlides S,Pestell RG,Fatatis A,Witkiewicz AK,Vander Heiden MG,Migneco G,Chiavarina B,Frank PG,Capozza F,Flomenberg N,Martinez-Outschoorn UE,Sotgia F,Lisanti MP
Sat May 15 00:00:00 EDT 2010
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
Cell cycle (Georgetown, Tex.)
Migneco G,Whitaker-Menezes D,Chiavarina B,Castello-Cros R,Pavlides S,Pestell RG,Fatatis A,Flomenberg N,Tsirigos A,Howell A,Martinez-Outschoorn UE,Sotgia F,Lisanti MP
Tue Jun 15 00:00:00 EDT 2010
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
Cell cycle (Georgetown, Tex.)
Migneco G,Whitaker-Menezes D,Chiavarina B,Castello-Cros R,Pavlides S,Pestell RG,Fatatis A,Flomenberg N,Tsirigos A,Howell A,Martinez-Outschoorn UE,Sotgia F,Lisanti MP
Tue Jun 15 00:00:00 EDT 2010
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Nature
Christofk HR,Vander Heiden MG,Harris MH,Ramanathan A,Gerszten RE,Wei R,Fleming MD,Schreiber SL,Cantley LC
Thu Mar 13 00:00:00 EDT 2008
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Nature
Christofk HR,Vander Heiden MG,Harris MH,Ramanathan A,Gerszten RE,Wei R,Fleming MD,Schreiber SL,Cantley LC
Thu Mar 13 00:00:00 EDT 2008
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Nature
Christofk HR,Vander Heiden MG,Harris MH,Ramanathan A,Gerszten RE,Wei R,Fleming MD,Schreiber SL,Cantley LC
Thu Mar 13 00:00:00 EDT 2008
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Nature
Christofk HR,Vander Heiden MG,Harris MH,Ramanathan A,Gerszten RE,Wei R,Fleming MD,Schreiber SL,Cantley LC
Thu Mar 13 00:00:00 EDT 2008
