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Product Details
66672-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2E6F12
Immunogen
PLZF Fusion Protein Ag25180 (101-400 aa encoded by BC026902)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DLLYAAEIL EIEYLEEQCL KMLETIQASD DNDTEATMAD GGAEEEEDRK ARYLKNIFIS KHSSEESGYA SVAGQSLPGP MVDQSPSVST SFGLSAMSPT KAAVDSLMTI GQSLLQGTLQ PPAGPEEPTL AGGGRHPGVA EVKTEMMQVD EVPSQDSPGA AESSISGGMG DKVEERGKEG PGTPTRSSVI TSARELHYGR EESAEQVPPP AEAGQAPTGR PEHPAPPPEK HLGIYSVLPN HKADAVLSMP SSVTSGLHVQ PALAVSMDFS TYGGLLPQGF IQRELFSKLG ELAVGMKSES R (101-400 aa encoded by BC026902)
Target Information
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Polydactyly-luxate syndrome; promyelocytic leukaemia zinc finger; promyelocytic leukemia zinc finger; Promyelocytic leukemia zinc finger protein; zinc finger and BTB domain containing 16 protein; Zinc finger and BTB domain-containing protein 16; Zinc finger protein 145; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); Zinc finger protein PLZF
Gene Aliases: Lx; PLZF; ZBTB16; Zfp145; ZNF145
UniProt ID: (Human) Q05516
Entrez Gene ID: (Human) 7704, (Rat) 353227
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
protein binding
protein C-terminus binding
protein domain specific binding
identical protein binding
protein homodimerization activity
metal ion binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
mesonephros development
transcription, DNA-templated
apoptotic process
central nervous system development
negative regulation of cell proliferation
embryonic pattern specification
anterior/posterior pattern specification
protein ubiquitination
hemopoiesis
myeloid cell differentiation
positive regulation of chondrocyte differentiation
protein localization to nucleus
embryonic hindlimb morphogenesis
forelimb morphogenesis
embryonic digit morphogenesis
positive regulation of apoptotic process
positive regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of ossification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
male germ-line stem cell asymmetric division
positive regulation of NK T cell differentiation
cartilage development
positive regulation of cartilage development
skeletal system development
regulation of transcription, DNA-templated
embryonic limb morphogenesis
hindlimb morphogenesis
Performance Guarantee
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