Product References
Metabolomic and transcriptomic studies of improvements in myocardial infarction due to Pycr1 deletion.
Journal of cellular and molecular medicine
Xue Z,Pan Y,Kong X,Zhang J,Wu D,Zhou B
Sun Jan 01 00:00:00 EST 2023
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Cell reports
Westbrook RL,Bridges E,Roberts J,Escribano-Gonzalez C,Eales KL,Vettore LA,Walker PD,Vera-Siguenza E,Rana H,Cuozzo F,Eskla KL,Vellama H,Shaaban A,Nixon C,Luuk H,Lavery GG,Hodson DJ,Harris AL,Tennant DA
Tue Feb 01 00:00:00 EST 2022
Epigenetic modification facilitates proline synthase PYCR1 aberrant expression in gastric cancer.
Biochimica et biophysica acta. Gene regulatory mechanisms
Xiao S,Yao X,Ye J,Tian X,Yin Z,Zhou L
Mon Aug 01 00:00:00 EDT 2022
Epigenetic modification facilitates proline synthase PYCR1 aberrant expression in gastric cancer.
Biochimica et biophysica acta. Gene regulatory mechanisms
Xiao S,Yao X,Ye J,Tian X,Yin Z,Zhou L
Mon Aug 01 00:00:00 EDT 2022
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Bioengineered
Zhang J,Shang L,Jiang W,Wu W
Tue Mar 01 00:00:00 EST 2022
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
American journal of respiratory cell and molecular biology
Zhang P,Wang J,Luo W,Yuan J,Cui C,Guo L,Wu C
Thu Jul 01 00:00:00 EDT 2021
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
American journal of respiratory cell and molecular biology
Zhang P,Wang J,Luo W,Yuan J,Cui C,Guo L,Wu C
Thu Jul 01 00:00:00 EDT 2021
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
American journal of respiratory cell and molecular biology
Zhang P,Wang J,Luo W,Yuan J,Cui C,Guo L,Wu C
Thu Jul 01 00:00:00 EDT 2021
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
American journal of respiratory cell and molecular biology
Zhang P,Wang J,Luo W,Yuan J,Cui C,Guo L,Wu C
Thu Jul 01 00:00:00 EDT 2021
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
American journal of respiratory cell and molecular biology
Zhang P,Wang J,Luo W,Yuan J,Cui C,Guo L,Wu C
Thu Jul 01 00:00:00 EDT 2021
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
American journal of respiratory cell and molecular biology
Zhang P,Wang J,Luo W,Yuan J,Cui C,Guo L,Wu C
Thu Jul 01 00:00:00 EDT 2021
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
American journal of respiratory cell and molecular biology
Zhang P,Wang J,Luo W,Yuan J,Cui C,Guo L,Wu C
Thu Jul 01 00:00:00 EDT 2021
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
American journal of respiratory cell and molecular biology
Zhang P,Wang J,Luo W,Yuan J,Cui C,Guo L,Wu C
Thu Jul 01 00:00:00 EDT 2021
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth.
Nature metabolism
Tran DH,Kesavan R,Rion H,Soflaee MH,Solmonson A,Bezwada D,Vu HS,Cai F,Phillips JA,DeBerardinis RJ,Hoxhaj G
Thu Apr 01 00:00:00 EDT 2021
Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis.
The EMBO journal
Chen Z,Wang C,Feng X,Nie L,Tang M,Zhang H,Xiong Y,Swisher SK,Srivastava M,Chen J
Wed Sep 01 00:00:00 EDT 2021
Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer.
Molecular therapy. Methods & clinical development
Liu Y,Xu Y,Jiang W,Ji H,Wang ZW,Zhu X
Fri Jun 11 00:00:00 EDT 2021
Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer.
Molecular therapy. Methods & clinical development
Liu Y,Xu Y,Jiang W,Ji H,Wang ZW,Zhu X
Fri Jun 11 00:00:00 EDT 2021
Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma.
International journal of biological sciences
Xu Y,Zuo W,Wang X,Zhang Q,Gan X,Tan N,Jia W,Liu J,Li Z,Zhou B,Zhao D,Xie Z,Tan Y,Zheng S,Liu C,Li H,Chen Z,Yang X,Huang Z
Fri Mar 25 00:00:00 EDT 2022
Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma.
International journal of biological sciences
Xu Y,Zuo W,Wang X,Zhang Q,Gan X,Tan N,Jia W,Liu J,Li Z,Zhou B,Zhao D,Xie Z,Tan Y,Zheng S,Liu C,Li H,Chen Z,Yang X,Huang Z
Fri Mar 25 00:00:00 EDT 2022
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.
Scientific reports
Jones B,Balasubramaniam M,Lebowitz JJ,Taylor A,Villalta F,Khoshbouei H,Grueter C,Grueter B,Dash C,Pandhare J
Thu Jan 14 00:00:00 EST 2021
Knockdown of PYCR1 suppressed the malignant phenotype of human hepatocellular carcinoma cells via inhibiting the AKT pathway activation.
Reproductive biology
Guo J,Cheng X,Tian Y,Li B,Zhang X,Gao X,An Y
Wed Sep 01 00:00:00 EDT 2021
PINCH-1 promotes Δ1-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma.
Amino acids
Cui C,Wang J,Guo L,Wu C
Wed Dec 01 00:00:00 EST 2021
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Neuron
Escande-Beillard N,Loh A,Saleem SN,Kanata K,Hashimoto Y,Altunoglu U,Metoska A,Grandjean J,Ng FM,Pomp O,Baburajendran N,Wong J,Hill J,Beillard E,Cozzone P,Zaki M,Kayserili H,Hamada H,Shiratori H,Reversade B
Wed Jul 08 00:00:00 EDT 2020
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Neuron
Escande-Beillard N,Loh A,Saleem SN,Kanata K,Hashimoto Y,Altunoglu U,Metoska A,Grandjean J,Ng FM,Pomp O,Baburajendran N,Wong J,Hill J,Beillard E,Cozzone P,Zaki M,Kayserili H,Hamada H,Shiratori H,Reversade B
Wed Jul 08 00:00:00 EDT 2020
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Neuron
Escande-Beillard N,Loh A,Saleem SN,Kanata K,Hashimoto Y,Altunoglu U,Metoska A,Grandjean J,Ng FM,Pomp O,Baburajendran N,Wong J,Hill J,Beillard E,Cozzone P,Zaki M,Kayserili H,Hamada H,Shiratori H,Reversade B
Wed Jul 08 00:00:00 EDT 2020
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Neuron
Escande-Beillard N,Loh A,Saleem SN,Kanata K,Hashimoto Y,Altunoglu U,Metoska A,Grandjean J,Ng FM,Pomp O,Baburajendran N,Wong J,Hill J,Beillard E,Cozzone P,Zaki M,Kayserili H,Hamada H,Shiratori H,Reversade B
Wed Jul 08 00:00:00 EDT 2020
Cancer progression is mediated by proline catabolism in non-small cell lung cancer.
Oncogene
Liu Y,Mao C,Wang M,Liu N,Ouyang L,Liu S,Tang H,Cao Y,Liu S,Wang X,Xiao D,Chen C,Shi Y,Yan Q,Tao Y
Sun Mar 01 00:00:00 EST 2020
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
Journal of hepatology
Ding Z,Ericksen RE,Escande-Beillard N,Lee QY,Loh A,Denil S,Steckel M,Haegebarth A,Wai Ho TS,Chow P,Toh HC,Reversade B,Gruenewald S,Han W
Wed Apr 01 00:00:00 EDT 2020
Proteomic patterns associated with response to breast cancer neoadjuvant treatment.
Molecular systems biology
Shenoy A,Belugali Nataraj N,Perry G,Loayza Puch F,Nagel R,Marin I,Balint N,Bossel N,Pavlovsky A,Barshack I,Kaufman B,Agami R,Yarden Y,Dadiani M,Geiger T
Tue Sep 01 00:00:00 EDT 2020
Proteomic patterns associated with response to breast cancer neoadjuvant treatment.
Molecular systems biology
Shenoy A,Belugali Nataraj N,Perry G,Loayza Puch F,Nagel R,Marin I,Balint N,Bossel N,Pavlovsky A,Barshack I,Kaufman B,Agami R,Yarden Y,Dadiani M,Geiger T
Tue Sep 01 00:00:00 EDT 2020
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Wang J,Yuan J,Yang Q,Zhang P,Su W,Bao R,Ran J,Wu C
Thu Oct 01 00:00:00 EDT 2020
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Wang J,Yuan J,Yang Q,Zhang P,Su W,Bao R,Ran J,Wu C
Thu Oct 01 00:00:00 EDT 2020
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Wang J,Yuan J,Yang Q,Zhang P,Su W,Bao R,Ran J,Wu C
Thu Oct 01 00:00:00 EDT 2020
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Annals of translational medicine
Xiao S,Li S,Yuan Z,Zhou L
Sat Aug 01 00:00:00 EDT 2020
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Annals of translational medicine
Xiao S,Li S,Yuan Z,Zhou L
Sat Aug 01 00:00:00 EDT 2020
Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation.
Biochemical pharmacology
Wang J,Xue Z,Lin J,Wang Y,Ying H,Lv Q,Hua C,Wang M,Chen S,Zhou B
Sat Aug 01 00:00:00 EDT 2020
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Zhang K,Wang J,Wang Y,Lu Y,Chen K,Yuan J,Xiao G,Tang B,Sun Y,Wu C
Tue Feb 19 00:00:00 EST 2019
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Zhang K,Wang J,Wang Y,Lu Y,Chen K,Yuan J,Xiao G,Tang B,Sun Y,Wu C
Tue Feb 19 00:00:00 EST 2019
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Zhang K,Wang J,Wang Y,Lu Y,Chen K,Yuan J,Xiao G,Tang B,Sun Y,Wu C
Tue Feb 19 00:00:00 EST 2019
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Zhang K,Wang J,Wang Y,Lu Y,Chen K,Yuan J,Xiao G,Tang B,Sun Y,Wu C
Tue Feb 19 00:00:00 EST 2019
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Zhang K,Wang J,Wang Y,Lu Y,Chen K,Yuan J,Xiao G,Tang B,Sun Y,Wu C
Tue Feb 19 00:00:00 EST 2019
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Zhang K,Wang J,Wang Y,Lu Y,Chen K,Yuan J,Xiao G,Tang B,Sun Y,Wu C
Tue Feb 19 00:00:00 EST 2019
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Zhang K,Wang J,Wang Y,Lu Y,Chen K,Yuan J,Xiao G,Tang B,Sun Y,Wu C
Tue Feb 19 00:00:00 EST 2019
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Nature communications
Guo L,Cui C,Zhang K,Wang J,Wang Y,Lu Y,Chen K,Yuan J,Xiao G,Tang B,Sun Y,Wu C
Tue Feb 19 00:00:00 EST 2019
SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.
Neoplasia (New York, N.Y.)
Chen S,Yang X,Yu M,Wang Z,Liu B,Liu M,Liu L,Ren M,Qi H,Zou J,Vucenik I,Zhu WG,Luo J
Mon Jul 01 00:00:00 EDT 2019
SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.
Neoplasia (New York, N.Y.)
Chen S,Yang X,Yu M,Wang Z,Liu B,Liu M,Liu L,Ren M,Qi H,Zou J,Vucenik I,Zhu WG,Luo J
Mon Jul 01 00:00:00 EDT 2019
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
American journal of respiratory cell and molecular biology
Hamanaka RB,O'Leary EM,Witt LJ,Tian Y,Gökalp GA,Meliton AY,Dulin NO,Mutlu GM
Fri Nov 01 00:00:00 EDT 2019
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Cell metabolism
Dogan SA,Cerutti R,Benincá C,Brea-Calvo G,Jacobs HT,Zeviani M,Szibor M,Viscomi C
Tue Nov 06 00:00:00 EST 2018
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Cell metabolism
Dogan SA,Cerutti R,Benincá C,Brea-Calvo G,Jacobs HT,Zeviani M,Szibor M,Viscomi C
Tue Nov 06 00:00:00 EST 2018
A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder.
Aging and disease
Huang YW,Chiang MF,Ho CS,Hung PL,Hsu MH,Lee TH,Chu LJ,Liu H,Tang P,Victor Ng W,Lin DS
Sat Dec 01 00:00:00 EST 2018
A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder.
Aging and disease
Huang YW,Chiang MF,Ho CS,Hung PL,Hsu MH,Lee TH,Chu LJ,Liu H,Tang P,Victor Ng W,Lin DS
Sat Dec 01 00:00:00 EST 2018
Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma.
Cancer management and research
Ye Y,Wu Y,Wang J
Wed Mar 30 00:00:00 EDT 2022
Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma.
Cancer management and research
Ye Y,Wu Y,Wang J
Wed Mar 30 00:00:00 EDT 2022
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Cell reports
Hollinshead KER,Munford H,Eales KL,Bardella C,Li C,Escribano-Gonzalez C,Thakker A,Nonnenmacher Y,Kluckova K,Jeeves M,Murren R,Cuozzo F,Ye D,Laurenti G,Zhu W,Hiller K,Hodson DJ,Hua W,Tomlinson IP,Ludwig C,Mao Y,Tennant DA
Tue Mar 20 00:00:00 EDT 2018
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Cell reports
Hollinshead KER,Munford H,Eales KL,Bardella C,Li C,Escribano-Gonzalez C,Thakker A,Nonnenmacher Y,Kluckova K,Jeeves M,Murren R,Cuozzo F,Ye D,Laurenti G,Zhu W,Hiller K,Hodson DJ,Hua W,Tomlinson IP,Ludwig C,Mao Y,Tennant DA
Tue Mar 20 00:00:00 EDT 2018
Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.
Biochemical and biophysical research communications
Iyer S,Park MJ,Moons D,Kwan R,Liao J,Liu L,Omary MB
Sun Jan 22 00:00:00 EST 2017
Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.
Biochemical and biophysical research communications
Iyer S,Park MJ,Moons D,Kwan R,Liao J,Liu L,Omary MB
Sun Jan 22 00:00:00 EST 2017
Sublethal endoplasmic reticulum stress caused by the mutation of immunoglobulin heavy chain-binding protein induces the synthesis of a mitochondrial protein, pyrroline-5-carboxylate reductase 1.
Cell stress & chaperones
Jin H,Komita M,Koseki H,Aoe T
Sun Jan 01 00:00:00 EST 2017
Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals.
eLife
Kühl I,Miranda M,Atanassov I,Kuznetsova I,Hinze Y,Mourier A,Filipovska A,Larsson NG
Tue Nov 14 00:00:00 EST 2017
Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals.
eLife
Kühl I,Miranda M,Atanassov I,Kuznetsova I,Hinze Y,Mourier A,Filipovska A,Larsson NG
Tue Nov 14 00:00:00 EST 2017
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.
Nature
Loayza-Puch F,Rooijers K,Buil LC,Zijlstra J,Oude Vrielink JF,Lopes R,Ugalde AP,van Breugel P,Hofland I,Wesseling J,van Tellingen O,Bex A,Agami R
Thu Feb 25 00:00:00 EST 2016
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.
Nature
Loayza-Puch F,Rooijers K,Buil LC,Zijlstra J,Oude Vrielink JF,Lopes R,Ugalde AP,van Breugel P,Hofland I,Wesseling J,van Tellingen O,Bex A,Agami R
Thu Feb 25 00:00:00 EST 2016
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.
Nature
Loayza-Puch F,Rooijers K,Buil LC,Zijlstra J,Oude Vrielink JF,Lopes R,Ugalde AP,van Breugel P,Hofland I,Wesseling J,van Tellingen O,Bex A,Agami R
Thu Feb 25 00:00:00 EST 2016
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.
Nature
Loayza-Puch F,Rooijers K,Buil LC,Zijlstra J,Oude Vrielink JF,Lopes R,Ugalde AP,van Breugel P,Hofland I,Wesseling J,van Tellingen O,Bex A,Agami R
Thu Feb 25 00:00:00 EST 2016
PYCR2 Mutations cause a lethal syndrome of microcephaly and failure to thrive.
Annals of neurology
Zaki MS,Bhat G,Sultan T,Issa M,Jung HJ,Dikoglu E,Selim L,G Mahmoud I,Abdel-Hamid MS,Abdel-Salam G,Marin-Valencia I,Gleeson JG
Fri Jul 01 00:00:00 EDT 2016
PYCR2 Mutations cause a lethal syndrome of microcephaly and failure to thrive.
Annals of neurology
Zaki MS,Bhat G,Sultan T,Issa M,Jung HJ,Dikoglu E,Selim L,G Mahmoud I,Abdel-Hamid MS,Abdel-Salam G,Marin-Valencia I,Gleeson JG
Fri Jul 01 00:00:00 EDT 2016
Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides.
Scientific reports
Liu W,Hancock CN,Fischer JW,Harman M,Phang JM
Tue Nov 24 00:00:00 EST 2015
Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides.
Scientific reports
Liu W,Hancock CN,Fischer JW,Harman M,Phang JM
Tue Nov 24 00:00:00 EST 2015
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
Proceedings of the National Academy of Sciences of the United States of America
Liu W,Le A,Hancock C,Lane AN,Dang CV,Fan TW,Phang JM
Tue Jun 05 00:00:00 EDT 2012
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
Proceedings of the National Academy of Sciences of the United States of America
Liu W,Le A,Hancock C,Lane AN,Dang CV,Fan TW,Phang JM
Tue Jun 05 00:00:00 EDT 2012
Understanding pyrroline-5-carboxylate synthetase deficiency: clinical, molecular, functional, and expression studies, structure-based analysis, and novel therapy with arginine.
Journal of inherited metabolic disease
Martinelli D,Häberle J,Rubio V,Giunta C,Hausser I,Carrozzo R,Gougeard N,Marco-Marín C,Goffredo BM,Meschini MC,Bevivino E,Boenzi S,Colafati GS,Brancati F,Baumgartner MR,Dionisi-Vici C
Sat Sep 01 00:00:00 EDT 2012
Understanding pyrroline-5-carboxylate synthetase deficiency: clinical, molecular, functional, and expression studies, structure-based analysis, and novel therapy with arginine.
Journal of inherited metabolic disease
Martinelli D,Häberle J,Rubio V,Giunta C,Hausser I,Carrozzo R,Gougeard N,Marco-Marín C,Goffredo BM,Meschini MC,Bevivino E,Boenzi S,Colafati GS,Brancati F,Baumgartner MR,Dionisi-Vici C
Sat Sep 01 00:00:00 EDT 2012
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Nature
Possemato R,Marks KM,Shaul YD,Pacold ME,Kim D,Birsoy K,Sethumadhavan S,Woo HK,Jang HG,Jha AK,Chen WW,Barrett FG,Stransky N,Tsun ZY,Cowley GS,Barretina J,Kalaany NY,Hsu PP,Ottina K,Chan AM,Yuan B,Garraway LA,Root DE,Mino-Kenudson M,Brachtel EF,Driggers EM,Sabatini DM
Thu Aug 18 00:00:00 EDT 2011
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Nature
Possemato R,Marks KM,Shaul YD,Pacold ME,Kim D,Birsoy K,Sethumadhavan S,Woo HK,Jang HG,Jha AK,Chen WW,Barrett FG,Stransky N,Tsun ZY,Cowley GS,Barretina J,Kalaany NY,Hsu PP,Ottina K,Chan AM,Yuan B,Garraway LA,Root DE,Mino-Kenudson M,Brachtel EF,Driggers EM,Sabatini DM
Thu Aug 18 00:00:00 EDT 2011
Compound heterozygous mutations in PYCR1 further expand the phenotypic spectrum of De Barsy syndrome.
American journal of medical genetics. Part A
Lin DS,Chang JH,Liu HL,Wei CH,Yeung CY,Ho CS,Shu CH,Chiang MF,Chuang CK,Huang YW,Wu TY,Jian YR,Huang ZD,Lin SP
Thu Dec 01 00:00:00 EST 2011
Compound heterozygous mutations in PYCR1 further expand the phenotypic spectrum of De Barsy syndrome.
American journal of medical genetics. Part A
Lin DS,Chang JH,Liu HL,Wei CH,Yeung CY,Ho CS,Shu CH,Chiang MF,Chuang CK,Huang YW,Wu TY,Jian YR,Huang ZD,Lin SP
Thu Dec 01 00:00:00 EST 2011
A novel mutation in PYCR1 causes an autosomal recessive cutis laxa with premature aging features in a family.
American journal of medical genetics. Part A
Lin DS,Yeung CY,Liu HL,Ho CS,Shu CH,Chuang CK,Huang YW,Wu TY,Huang ZD,Jian YR,Lin SP
Wed Jun 01 00:00:00 EDT 2011
A novel mutation in PYCR1 causes an autosomal recessive cutis laxa with premature aging features in a family.
American journal of medical genetics. Part A
Lin DS,Yeung CY,Liu HL,Ho CS,Shu CH,Chuang CK,Huang YW,Wu TY,Huang ZD,Jian YR,Lin SP
Wed Jun 01 00:00:00 EDT 2011
Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1, encoding Δ¹-pyrroline-5-carboxylate synthase (P5CS).
American journal of medical genetics. Part A
Skidmore DL,Chitayat D,Morgan T,Hinek A,Fischer B,Dimopoulou A,Somers G,Halliday W,Blaser S,Diambomba Y,Lemire EG,Kornak U,Robertson SP
Mon Aug 01 00:00:00 EDT 2011
Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1, encoding Δ¹-pyrroline-5-carboxylate synthase (P5CS).
American journal of medical genetics. Part A
Skidmore DL,Chitayat D,Morgan T,Hinek A,Fischer B,Dimopoulou A,Somers G,Halliday W,Blaser S,Diambomba Y,Lemire EG,Kornak U,Robertson SP
Mon Aug 01 00:00:00 EDT 2011
Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1, encoding Δ¹-pyrroline-5-carboxylate synthase (P5CS).
American journal of medical genetics. Part A
Skidmore DL,Chitayat D,Morgan T,Hinek A,Fischer B,Dimopoulou A,Somers G,Halliday W,Blaser S,Diambomba Y,Lemire EG,Kornak U,Robertson SP
Mon Aug 01 00:00:00 EDT 2011
Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1, encoding Δ¹-pyrroline-5-carboxylate synthase (P5CS).
American journal of medical genetics. Part A
Skidmore DL,Chitayat D,Morgan T,Hinek A,Fischer B,Dimopoulou A,Somers G,Halliday W,Blaser S,Diambomba Y,Lemire EG,Kornak U,Robertson SP
Mon Aug 01 00:00:00 EDT 2011
Mutations in PYCR1 cause cutis laxa with progeroid features.
Nature genetics
Reversade B,Escande-Beillard N,Dimopoulou A,Fischer B,Chng SC,Li Y,Shboul M,Tham PY,Kayserili H,Al-Gazali L,Shahwan M,Brancati F,Lee H,O'Connor BD,Schmidt-von Kegler M,Merriman B,Nelson SF,Masri A,Alkazaleh F,Guerra D,Ferrari P,Nanda A,Rajab A,Markie D,Gray M,Nelson J,Grix A,Sommer A,Savarirayan R,Janecke AR,Steichen E,Sillence D,Hausser I,Budde B,Nürnberg G,Nürnberg P,Seemann P,Kunkel D,Zambruno G,Dallapiccola B,Schuelke M,Robertson S,Hamamy H,Wollnik B,Van Maldergem L,Mundlos S,Kornak U
Tue Sep 01 00:00:00 EDT 2009
Mutations in PYCR1 cause cutis laxa with progeroid features.
Nature genetics
Reversade B,Escande-Beillard N,Dimopoulou A,Fischer B,Chng SC,Li Y,Shboul M,Tham PY,Kayserili H,Al-Gazali L,Shahwan M,Brancati F,Lee H,O'Connor BD,Schmidt-von Kegler M,Merriman B,Nelson SF,Masri A,Alkazaleh F,Guerra D,Ferrari P,Nanda A,Rajab A,Markie D,Gray M,Nelson J,Grix A,Sommer A,Savarirayan R,Janecke AR,Steichen E,Sillence D,Hausser I,Budde B,Nürnberg G,Nürnberg P,Seemann P,Kunkel D,Zambruno G,Dallapiccola B,Schuelke M,Robertson S,Hamamy H,Wollnik B,Van Maldergem L,Mundlos S,Kornak U
Tue Sep 01 00:00:00 EDT 2009
Mutations in PYCR1 cause cutis laxa with progeroid features.
Nature genetics
Reversade B,Escande-Beillard N,Dimopoulou A,Fischer B,Chng SC,Li Y,Shboul M,Tham PY,Kayserili H,Al-Gazali L,Shahwan M,Brancati F,Lee H,O'Connor BD,Schmidt-von Kegler M,Merriman B,Nelson SF,Masri A,Alkazaleh F,Guerra D,Ferrari P,Nanda A,Rajab A,Markie D,Gray M,Nelson J,Grix A,Sommer A,Savarirayan R,Janecke AR,Steichen E,Sillence D,Hausser I,Budde B,Nürnberg G,Nürnberg P,Seemann P,Kunkel D,Zambruno G,Dallapiccola B,Schuelke M,Robertson S,Hamamy H,Wollnik B,Van Maldergem L,Mundlos S,Kornak U
Tue Sep 01 00:00:00 EDT 2009
Mutations in PYCR1 cause cutis laxa with progeroid features.
Nature genetics
Reversade B,Escande-Beillard N,Dimopoulou A,Fischer B,Chng SC,Li Y,Shboul M,Tham PY,Kayserili H,Al-Gazali L,Shahwan M,Brancati F,Lee H,O'Connor BD,Schmidt-von Kegler M,Merriman B,Nelson SF,Masri A,Alkazaleh F,Guerra D,Ferrari P,Nanda A,Rajab A,Markie D,Gray M,Nelson J,Grix A,Sommer A,Savarirayan R,Janecke AR,Steichen E,Sillence D,Hausser I,Budde B,Nürnberg G,Nürnberg P,Seemann P,Kunkel D,Zambruno G,Dallapiccola B,Schuelke M,Robertson S,Hamamy H,Wollnik B,Van Maldergem L,Mundlos S,Kornak U
Tue Sep 01 00:00:00 EDT 2009
