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Product Details
PA5-36819
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide derived from human AKT2 around the phosphorylation site of Serine 474
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2553754
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 60 kDa. It does not cross-react with AKT1 and AKT3 protein when phosphorylated at the corresponding residues.
Purity is >95% by SDS-PAGE.
Target Information
AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AKT2 kinase; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; RAC protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2
Gene Aliases: 2410016A19Rik; AKT2; AW554154; HIHGHH; PKB; PKBB; PKBBETA; PRKBB; RAC-BETA
UniProt ID: (Human) Q0VAN1, (Rat) P47197, (Mouse) Q60823
Entrez Gene ID: (Human) 208, (Rat) 25233, (Mouse) 11652
protein serine/threonine kinase activity
protein kinase C binding
protein binding
ATP binding
protein kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
positive regulation of protein phosphorylation
glycogen biosynthetic process
glucose metabolic process
regulation of translation
cellular protein modification process
apoptotic process
response to osmotic stress
signal transduction
insulin receptor signaling pathway
carbohydrate transport
positive regulation of signal transduction
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of glucose metabolic process
response to muscle activity
peptidyl-serine phosphorylation
regulation of cell migration
positive regulation of cell migration
positive regulation of vesicle fusion
response to nutrient levels
positive regulation of fatty acid beta-oxidation
peripheral nervous system myelin maintenance
cellular response to insulin stimulus
negative regulation of RNA splicing
positive regulation of peptidyl-serine phosphorylation
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
positive regulation of glycogen biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
positive regulation of positive chemotaxis
mammary gland epithelial cell differentiation
intracellular protein transmembrane transport
regulation of cell cycle arrest
cellular response to organic cyclic compound
protein localization to plasma membrane
positive regulation of protein targeting to membrane
activation of GTPase activity
positive regulation of cell motility
positive regulation of glucose import in response to insulin stimulus
protein phosphorylation
multicellular organism development
positive regulation of gene expression
positive regulation of sodium ion transport
response to insulin
cellular response to hormone stimulus
negative regulation of apoptotic process
carbohydrate metabolic process
glycogen metabolic process
transport
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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