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Product Details
PA5-67501
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide sequence derived from Human DAXX around phosphorylation site of serine 739 (L-S-D-S(p)-D).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2692163
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CENP-C binding protein; DADB-159G18.9; Daxx; Death domain-associated protein 6; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126245; MGC126246; SMIM40
Gene Aliases: BING2; DAP6; DAXX; EAP1
UniProt ID: (Human) F5ANJ6, (Mouse) O35613
Entrez Gene ID: (Human) 1616, (Mouse) 13163, (Rat) 140926
p53 binding
transcription corepressor activity
receptor signaling protein activity
protein binding
transcription factor binding
enzyme binding
protein kinase binding
protein kinase activator activity
heat shock protein binding
ubiquitin protein ligase binding
histone binding
protein N-terminus binding
androgen receptor binding
transcription coactivator activity
protein homodimerization activity
general transcription factor
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of JUN kinase activity
extrinsic apoptotic signaling pathway via death domain receptors
response to metal ion
negative regulation of myotube differentiation
viral process
covalent chromatin modification
androgen receptor signaling pathway
PML body organization
regulation of protein ubiquitination
positive regulation of histone phosphorylation
positive regulation of apoptotic process
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
cellular response to tumor necrosis factor
cellular response to anoxia
positive regulation of neuron death
mitotic cytokinesis
chromatin modification
positive regulation of transcription from RNA polymerase II promoter
apoptotic signaling pathway
negative regulation of nucleic acid-templated transcription
positive regulation of apoptotic signaling pathway
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