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Phospho-DOK2 (Tyr345) Antibody (PA5-118727) in IHC (P)
Immunohistochemical analysis of Phospho-DOK2 (Tyr345) in Mouse colorectal tissue using a Phospho-DOK2 (Tyr345) polyclonal antibody (Product # PA5-118727). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the seco... View More
Product Details
PA5-118727
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DOK2(Accession O60496), corresponding to amino acid residues around phosphorylated Tyr345.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903227
Product Specific Information
Antibody detects endogenous levels of DOK2 only when phosphorylated at Tyr345.
Target Information
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 from CML cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Docking protein 2; docking protein 2, 56kD; docking protein 2, 56kDa; Dok-R; Dok-related protein; Downstream of tyrosine kinase 2; FRIP; IL-Four Receptor Interacting Protein; IL-four receptor-interacting protein; p56 dok-2; p56(dok-2)
Gene Aliases: DOK2; DokR; Frip; p56DOK; p56dok-2
UniProt ID: (Human) O60496, (Mouse) O70469
Entrez Gene ID: (Human) 9046, (Mouse) 13449
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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