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Invitrogen
Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) Polyclonal Antibody
FIGURE: 1 / 5
Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) Antibody (PA5-105874) in IHC (P)
Immunohistochemistry analysis of Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) in human normal tissues adjacent to pancreatic cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) polyclonal antibody (Product # PA5-105874) using a dilution of 1:100 (4°C overnight) followed by HRP conju... View More
Product Details
PA5-105874
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DYRK1A(Accession Q13627), corresponding to amino acid residues around phosphorylated Tyr321.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2817273
Product Specific Information
Antibody detects endogenous levels of DYRK1A/B only when phosphorylated at Tyr321/273.
Target Information
DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual Specificity Yak1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; hMNB; HP86; Minibrain-related kinase; Mirk protein kinase; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MP86; Protein kinase minibrain homolog; RP86; serine/threonine kinase MNB; serine/threonine-specific protein kinase
Gene Aliases: 2310043O08Rik; AOMS3; D16Ertd272e; D16Ertd493e; DYRK; DYRK1; DYRK1A; DYRK1B; ENSMUSG00000074897; Gm10783; HP86; MIRK; mmb; MNB; MNBH; Mp86; MRD7; PSK47
UniProt ID: (Human) Q13627, (Human) Q9Y463, (Mouse) Q61214, (Rat) Q63470, (Mouse) Q9Z188
Entrez Gene ID: (Human) 1859, (Human) 9149, (Mouse) 13548, (Rat) 25255, (Mouse) 13549, (Rat) 308468
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
identical protein binding
protein self-association
tau protein binding
transcription coactivator activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
myoblast fusion
peptidyl-tyrosine phosphorylation
positive regulation of transcription, DNA-templated
adipose tissue development
regulation of alternative mRNA splicing, via spliceosome
circadian rhythm
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
negative regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
negative regulation of mRNA splicing, via spliceosome
positive regulation of protein deacetylation
nervous system development
regulation of endocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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