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Product Details
PA5-37572
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of threonine 38(L-L-T(p)-P-S) derived from Human ETS1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2554180
Product Specific Information
A suggested positive control for Western blot is HepG2 cells; suggested positive control for IHC is human breast carcinoma; suggested positive control for ICC/IF is Hela cells.
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54), a 441 A. A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; avian erythroblastosis virus E26 oncogene 1; ets protein; Ets-1Delta(III-VI); FLJ10768; p54; Protein C-ets-1; tumor progression locus 1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1
Gene Aliases: AI196000; AI448617; c-ets-1; D230050P06; ETS-1; ETS1; EWSR2; p54; Tpl1
UniProt ID: (Human) P14921, (Mouse) P27577
Entrez Gene ID: (Human) 2113, (Mouse) 23871
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
histone acetyltransferase binding
identical protein binding
sequence-specific DNA binding
winged helix/forkhead transcription factor
response to hypoxia
immune response
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
response to mechanical stimulus
positive regulation of endothelial cell migration
regulation of extracellular matrix disassembly
hypothalamus development
pituitary gland development
PML body organization
response to estradiol
response to laminar fluid shear stress
estrous cycle
positive regulation of erythrocyte differentiation
regulation of angiogenesis
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell motility
negative regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of cellular component movement
angiogenesis involved in wound healing
pri-miRNA transcription from RNA polymerase II promoter
cellular response to hydrogen peroxide
response to interleukin-1
positive regulation of leukocyte adhesion to vascular endothelial cell
immune system process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cell differentiation
positive regulation of cell migration
regulation of apoptotic process
negative regulation of cell cycle
response to antibiotic
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