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Phospho-GAB2 (Ser159) Antibody (PA5-105241) in IHC (P)
Immunohistochemistry analysis of Phospho-GAB2 (Ser159) in human pancreatic cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-GAB2 (Ser159) polyclonal antibody (Product # PA5-105241) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-105241
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GAB2(Accession Q9UQC2), corresponding to amino acid residues around phosphorylated Ser159.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2816714
Product Specific Information
Antibody detects endogenous levels of Gab2 only when phosphorylated at Ser159.
Target Information
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Grb2 associated binder 2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; GRB3-3; Growth factor receptor bound protein 2-associated protein 2; PH domain-containing adaptor molecule p97; pp100
Gene Aliases: AI463667; D130058I17Rik; GAB2; KIAA0571; p97
UniProt ID: (Human) Q9UQC2, (Rat) Q9EQH1
Entrez Gene ID: (Human) 9846, (Rat) 84477, (Mouse) 14389
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
osteoclast differentiation
Fc-epsilon receptor signaling pathway
positive regulation of mast cell degranulation
phosphatidylinositol-mediated signaling
integrin-mediated signaling pathway
cell migration
intracellular signal transduction
positive regulation of signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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