Invitrogen

Phospho-JNK1/JNK2/JNK3 (Thr183) Polyclonal Antibody

View all (30) JNK1/JNK2/JNK3 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-99374

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MAPK8(Accession P45983), corresponding to amino acid residues around phosphorylated Thr183.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2818307

Product Specific Information

Antibody detects endogenous levels of JNK1/2/3 only when phosphorylated at Threonine 183.

Target Information

C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Jun kinase 2; c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 2; c-Jun N-terminal kinase 3; FLJ12099; FLJ33785; JNK 46; JNK 55; JNK-46; JNK-55; JNK/SAPK alpha; JNK1 beta1 protein kinase; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; Jun kinase; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAP kinase 9; MAP kinase p49 3F12; MAPK 10; MAPK 8; MAPK 9; MGC50974; Mi; mitogen activated protein kinase 10; mitogen activated protein kinase 8; mitogen activated protein kinase 9; Mitogen-activated protein kinase 10; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; Mitogen-activated protein kinase 9; MK10; p54 gamma; p54-alpha; p54-beta; Phospho-JNK; protein kinase mitogen-activated 8; protein kinase, mitogen-activated 9; SAPK gamma; SAPK-alpha; SAPK-beta; SAPK/Erk/kinase 2; SAPK1a; SAPK1b; SAPK1c; stress activated protein kinase alpha II; Stress activated protein kinase beta; stress-activated protein kinase 1; Stress-activated protein kinase 1a; Stress-activated protein kinase 1b; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; Stress-activated protein kinase JNK2; Stress-activated protein kinase JNK3

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Gene Aliases: AI849689; AI851083; C230008H04Rik; JNK; JNK-46; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; MAPK8; MAPK9; p493F12; p54a; p54aSAPK; p54bSAPK; PRKM10; PRKM8; PRKM9; SAPb; SAPK; SAPK(beta); SAPK1; SAPK1A; SAPK1B; SAPK1C; SAPKC; Serk2

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UniProt ID: (Human) P53779, (Human) P45983, (Human) P45984, (Mouse) Q61831, (Rat) P49187, (Rat) P49185, (Mouse) Q91Y86, (Rat) P49186, (Mouse) Q9WTU6

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Entrez Gene ID: (Human) 5602, (Human) 5599, (Human) 5601, (Mouse) 26414, (Rat) 25272, (Rat) 116554, (Mouse) 26419, (Rat) 50658, (Mouse) 26420

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Function(s)
JUN kinase activity MAP kinase kinase activity protein binding ATP binding protein serine/threonine kinase activity kinase activity enzyme binding histone deacetylase regulator activity histone deacetylase binding transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process mitogen-activated protein kinase kinase kinase binding nucleotide binding protein kinase activity MAP kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
activation of MAPK activity protein phosphorylation signal transduction JNK cascade JUN phosphorylation response to light stimulus Fc-epsilon receptor signaling pathway regulation of circadian rhythm rhythmic process regulation of sequence-specific DNA binding transcription factor activity response to stress response to UV positive regulation of gene expression regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation regulation of histone deacetylation positive regulation of cyclase activity negative regulation of protein binding regulation of protein localization positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of protein metabolic process cellular response to lipopolysaccharide cellular response to mechanical stimulus positive regulation of deacetylase activity positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway release of cytochrome c from mitochondria positive regulation of protein phosphorylation protein targeting to mitochondrion activation of cysteine-type endopeptidase activity involved in apoptotic process central nervous system development response to mechanical stimulus response to toxic substance positive regulation of macrophage derived foam cell differentiation positive regulation of cell morphogenesis involved in differentiation response to amine neuron projection development positive regulation of prostaglandin biosynthetic process regulation of protein ubiquitination positive regulation of prostaglandin secretion positive regulation of chemokine production cellular response to UV response to drug positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated regulation of JNK cascade response to cadmium ion positive regulation of nitric-oxide synthase biosynthetic process cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to growth factor stimulus positive regulation of podosome assembly positive regulation of apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter phosphorylation locomotor rhythm MAPK cascade ossification regulation of transcription, DNA-templated inflammatory response response to osmotic stress response to heat regulation of gene expression positive regulation of cell migration positive regulation of microtubule polymerization response to hydrogen peroxide positive regulation of DNA replication determination of dorsal identity cellular response to hydrogen peroxide cellular response to nitric oxide type B pancreatic cell apoptotic process neuronal stem cell population maintenance programmed necrotic cell death positive regulation of determination of dorsal identity response to organic substance positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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