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Invitrogen
Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody
Product Details
PA5-64591
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LATS1/2 (Phospho-Ser909/872)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2664907
Product Specific Information
Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody detects endogenous levels of LATS1/LATS2 only when phosphorylated at Ser909, Ser872.
Target Information
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: h-warts; Kinase phosphorylated during mitosis protein; large tumor suppressor 2; Large tumor suppressor homolog 1; Large tumor suppressor homolog 2; large tumor suppressor, homolog 2; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 1; LATS, large tumor suppressor, homolog 2; LATS1; LATS2; serine/threonine kinase KPM; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS1; Serine/threonine-protein kinase LATS2; WARTS protein kinase; Warts-like kinase
Gene Aliases: 4932411G09Rik; AV277261; AW208599; AW228608; KPM; LATS1; LATS2; RGD1564085; WARTS; wts
UniProt ID: (Human) O95835, (Human) Q9NRM7, (Mouse) Q8BYR2, (Mouse) Q7TSJ6
Entrez Gene ID: (Human) 9113, (Human) 26524, (Rat) 308265, (Mouse) 16798, (Mouse) 50523, (Rat) 305922
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase binding
metal ion binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
sister chromatid segregation
inner cell mass cell fate commitment
inner cell mass cellular morphogenesis
protein phosphorylation
mitotic nuclear division
hormone-mediated signaling pathway
keratinocyte differentiation
regulation of actin filament polymerization
positive regulation of peptidyl-serine phosphorylation
hippo signaling
positive regulation of apoptotic process
regulation of protein complex assembly
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of organ growth
cytoplasmic sequestering of protein
cell division
negative regulation of canonical Wnt signaling pathway
peptidyl-serine phosphorylation
cellular protein localization
intracellular signal transduction
cell cycle
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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