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Product Details
BS-5493R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human MAP4K4 around the phosphorylation site of Ser801.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MAP4K4 (HGK) is a serine/threonine kinase which plays an important role in stress-activated MAPK core signaling pathways, the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory protein Li 31; FLJ10410; FLJ20373; FLJ90111; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; mitogen activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4; NCK interacting kinase; Nck-interacting kinase; Ste20 group protein kinase HGK
Gene Aliases: 9430080K19Rik; AU043147; AU045934; AW046177; FLH21957; HEL-S-31; HGK; KIAA0687; MAP4K4; MEKKK4; NIK
UniProt ID: (Human) O95819, (Mouse) P97820
Entrez Gene ID: (Human) 9448, (Mouse) 26921, (Rat) 301363
creatine kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
non-receptor serine/threonine protein kinase
protein phosphorylation
signal transduction by protein phosphorylation
microvillus assembly
intracellular signal transduction
negative regulation of apoptotic process
regulation of JNK cascade
MAPK cascade
response to stress
regulation of mitotic cell cycle
negative regulation of neuron projection development
phosphorylation
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
neuron projection morphogenesis
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of neuron projection regeneration
regulation of catalytic activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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