Product References
Lack of Paxillin phosphorylation promotes single-cell migration in vivo.
The Journal of cell biology
Xue Q,Varady SRS,Waddell TQA,Roman MR,Carrington J,Roh-Johnson M
44-720G was used in Western Blotting to provide significant new insight into the intrinsic regulation of focal adhesions in cells migrating in their native environment.
Mon Mar 06 00:00:00 EST 2023
Lack of Paxillin phosphorylation promotes single-cell migration in vivo.
The Journal of cell biology
Xue Q,Varady SRS,Waddell TQA,Roman MR,Carrington J,Roh-Johnson M
44-720G was used in Western Blotting to provide significant new insight into the intrinsic regulation of focal adhesions in cells migrating in their native environment.
Mon Mar 06 00:00:00 EST 2023
Oxidative stress-induced FAK activation contributes to uterine serous carcinoma aggressiveness.
Molecular oncology
Lopez-Mejia IC,Pijuan J,Navaridas R,Santacana M,Gatius S,Velasco A,Castellà G,Panosa A,Cabiscol E,Pinyol M,Coll L,Bonifaci N,Peña LP,Vidal A,Villanueva A,Gari E,Llobet-Navàs D,Fajas L,Matias-Guiu X,Yeramian A
44-720G was used in Western Blotting to quantify the changes in tyrosine kinase activation between uterine serous carcinoma (USC) and endometrioid endometrial carcinoma (EEC).
Sun Jan 01 00:00:00 EST 2023
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
Bioactive materials
Guo Y,Mei F,Huang Y,Ma S,Wei Y,Zhang X,Xu M,He Y,Heng BC,Chen L,Deng X
Published figure using Phospho-Paxillin (Tyr31) polyclonal antibody (Product # 44-720G) in Western Blot
Sat Jan 01 00:00:00 EST 2022
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
Bioactive materials
Guo Y,Mei F,Huang Y,Ma S,Wei Y,Zhang X,Xu M,He Y,Heng BC,Chen L,Deng X
Published figure using Phospho-Paxillin (Tyr31) polyclonal antibody (Product # 44-720G) in Western Blot
Sat Jan 01 00:00:00 EST 2022
Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity.
Aging
Haroon M,Boers HE,Bakker AD,Bloks NGC,Hoogaars WMH,Giordani L,Musters RJP,Deldicque L,Koppo K,Le Grand F,Klein-Nulend J,Jaspers RT
44-720G was used in Immunohistochemistry to study how muscle stem cell (MuSC) alterations and dysfunctional mechanosensitivity cause aging-associated impaired muscle regenerative capacity and muscle wasting.
Thu Jan 13 00:00:00 EST 2022
ARHGEF9 regulates melanoma morphogenesis in environments with diverse geometry and elasticity by promoting filopodial-driven adhesion.
iScience
Bousgouni V,Inge O,Robertson D,Jones I,Clatworthy I,Bakal C
44-720G was used in Immunocytochemistry-immunoflourescence to show that ARHGEF9 promotes the formation of actin-rich filopodia, which serves to establish and stabilize adhesions and determine melanoma cell shape.
Fri Aug 19 00:00:00 EDT 2022
Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.
Cell
Nava MM,Miroshnikova YA,Biggs LC,Whitefield DB,Metge F,Boucas J,Vihinen H,Jokitalo E,Li X,García Arcos JM,Hoffmann B,Merkel R,Niessen CM,Dahl KN,Wickström SA
44-720G was used in Western Blotting to identify an unconventional role of chromatin in altering its own mechanical state to maintain genome integrity in response to deformation.
Thu May 14 00:00:00 EDT 2020
Basement Membrane Regulates Fibronectin Organization Using Sliding Focal Adhesions Driven by a Contractile Winch.
Developmental cell
Lu J,Doyle AD,Shinsato Y,Wang S,Bodendorfer MA,Zheng M,Yamada KM
44-720G was used in Immunocytochemistry to describe a type of dynamic cell-BM matrix assembly mechanism that produces rapid, extensive FN fibrillogenesis in a process that can explain the characteristic pattern of FN matrix deposition on BMs.
Mon Mar 09 00:00:00 EDT 2020
RGD-functionalized supported lipid bilayers modulate pre-osteoblast adherence and promote osteogenic differentiation.
Journal of biomedical materials research. Part A
Verstappen JFM,Jin J,Koçer G,Haroon M,Jonkheijm P,Bakker AD,Klein-Nulend J,Jaspers RT
44-720G was used in Immunocytochemistry-immunoflourescence to demonstrate that pre-osteoblast adhesion and enhanced differentiation were realized for the first time on RGD-functionalized SLBs, pointing to a new horizon in the management of bone regeneration using biomaterials.
Wed Apr 01 00:00:00 EDT 2020
Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity.
Experimental cell research
Tilve S,Iweka CA,Bao J,Hawken N,Mencio CP,Geller HM
44-720G was used in Immunocytochemistry to show that PLPPR1 decreases active Rac1 levels that leads to cascade of events which increases cell adhesion.
Wed Apr 15 00:00:00 EDT 2020
Coupling of β2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis.
Nature cell biology
Jaumouillé V,Cartagena-Rivera AX,Waterman CM
44-720G was used in Immunocytochemistry-immunoflourescence to investigate whether mechanical coupling of αMβ2 integrin to the actin cytoskeleton mediates phagocytosis.
Fri Nov 01 00:00:00 EDT 2019
Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling.
Journal of cell science
Rahikainen R,Öhman T,Turkki P,Varjosalo M,Hytönen VP
44-720G was used in Immunocytochemistry to identify specific adhesome components that are recruited and activated either in a talin rod-dependent manner or independently of the rod subdomains through the use of proteomics tools.
Wed Apr 03 00:00:00 EDT 2019
Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma.
Scientific reports
Rezey AC,Gerlach BD,Wang R,Liao G,Tang DD
Published figure using Phospho-Paxillin (Tyr31) polyclonal antibody (Product # 44-720G) in Immunocytochemistry
Fri May 17 00:00:00 EDT 2019
Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2.
International journal of oncology
Iwasawa T,Zhang P,Ohkawa Y,Momota H,Wakabayashi T,Ohmi Y,Bhuiyan RH,Furukawa K,Furukawa K
44-720G was used in Western Blotting to suggest that GD3 and GD2 highly expressed in gliomas confer increased invasion and mobility, cell growth abilities under low serum conditions, and increased ratios of the S-G2/M phase in the cell cycle.
Sun Apr 01 00:00:00 EDT 2018
Nicotinic acid impairs assembly of leading edge in glioma cells.
Oncology reports
Yang X,Mei S,Niu H,Li J
44-720G was used in Immunocytochemistry to propose that NA treatment may be developed into a potential therapy for malignant glioma.
Tue Aug 01 00:00:00 EDT 2017
15-Deoxy-Δ12,14-prostaglandin J2 inhibits migration of human thyroid carcinoma cells by disrupting focal adhesion complex and adherens junction.
Oncology letters
Wu YC,Jhao YT,Cheng YC,Chen Y
44720G was used in western blot to elucidate the mechanism by which 15d-PGJ2 suppresses human thyroid carcinoma cell migration
Sat Apr 01 00:00:00 EDT 2017
Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion.
Developmental cell
Kraft-Sheleg O,Zaffryar-Eilot S,Genin O,Yaseen W,Soueid-Baumgarten S,Kessler O,Smolkin T,Akiri G,Neufeld G,Cinnamon Y,Hasson P
44-720G was used in immunohistochemistry to study regulation of myofiber stretch and integrin-mediated adhesion due to localized LoxL3-dependent fibronectin oxidation
Mon Mar 07 00:00:00 EST 2016
RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border.
The Journal of cell biology
Marcos-Ramiro B,García-Weber D,Barroso S,Feito J,Ortega MC,Cernuda-Morollón E,Reglero-Real N,Fernández-Martín L,Durán MC,Alonso MA,Correas I,Cox S,Ridley AJ,Millán J
44-720G was used in western blot to study inhibition of Rac1 trafficking to the cell border by RhoB control of the endothelial barrier recovery
Mon May 09 00:00:00 EDT 2016
Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.
The Journal of cell biology
Kumar A,Ouyang M,Van den Dries K,McGhee EJ,Tanaka K,Anderson MD,Groisman A,Goult BT,Anderson KI,Schwartz MA
44-720G was used in immunocytochemistry to learn the revelation of novel features of focal adhesion force transmission and mechanosensitivity by talin tension sensor
Mon May 09 00:00:00 EDT 2016
The Integrin-Mediated ILK-Parvin-αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells.
Journal of cellular physiology
Rooney N,Wang P,Brennan K,Gilmore AP,Streuli CH
44-720G was used in immunocytochemistry and western blot to learn about the control of differentiation in mammary epithelial cells by the integrin-mediated ILK-parvin-alpha-Pix signaling axis
Tue Nov 01 00:00:00 EDT 2016
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.
eLife
Theodosiou M,Widmaier M,Böttcher RT,Rognoni E,Veelders M,Bharadwaj M,Lambacher A,Austen K,Müller DJ,Zent R,Fässler R
44-720G was used in western blot to determine the role of Kindlin-2 tp activate integrins by cooperating with talin and induction of cell spreading by directly binding paxillin
Wed Jan 27 00:00:00 EST 2016
Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration.
Scientific reports
Wu JC,Chen YC,Kuo CT,Wenshin Yu H,Chen YQ,Chiou A,Kuo JC
44-720G was used in western blot to test if SRC, SHP1, and SHP2 target focal adhesions via their SH2 domains
Fri Dec 18 00:00:00 EST 2015
Dissecting motility signaling through activation of specific Src-effector complexes.
Nature chemical biology
Karginov AV,Tsygankov D,Berginski M,Chu PH,Trudeau ED,Yi JJ,Gomez S,Elston TC,Hahn KM
44-720G was used in western blot to describe a method to selectively and quickly activate a kinase in a specific protein complex or at a specific subcellular location within living cells.
Tue Apr 01 00:00:00 EDT 2014
Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Livshits G,Kobielak A,Fuchs E
Tue Mar 27 00:00:00 EDT 2012
Biophysical stimulation induces demyelination via an integrin-dependent mechanism.
Annals of neurology
Lin MY,Frieboes LS,Forootan M,Palispis WA,Mozaffar T,Jafari M,Steward O,Gall CM,Gupta R
Sun Jul 01 00:00:00 EDT 2012
Biophysical stimulation induces demyelination via an integrin-dependent mechanism.
Annals of neurology
Lin MY,Frieboes LS,Forootan M,Palispis WA,Mozaffar T,Jafari M,Steward O,Gall CM,Gupta R
Sun Jul 01 00:00:00 EDT 2012
Biophysical stimulation induces demyelination via an integrin-dependent mechanism.
Annals of neurology
Lin MY,Frieboes LS,Forootan M,Palispis WA,Mozaffar T,Jafari M,Steward O,Gall CM,Gupta R
Sun Jul 01 00:00:00 EDT 2012
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.
The Journal of biological chemistry
Lim ST,Chen XL,Tomar A,Miller NL,Yoo J,Schlaepfer DD
44-720G was used in immunocytochemistry and western blot to determine the role of FAK activity during development
Fri Jul 09 00:00:00 EDT 2010
Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK.
Cell death and differentiation
Owens TW,Valentijn AJ,Upton JP,Keeble J,Zhang L,Lindsay J,Zouq NK,Gilmore AP
44-720G was used in western blot to identify p38MAPK as an activator of Bax
Sun Nov 01 00:00:00 EDT 2009
Src inhibitors in early breast cancer: a methodology, feasibility and variability study.
Breast cancer research and treatment
Jones RJ,Young O,Renshaw L,Jacobs V,Fennell M,Marshall A,Green TP,Elvin P,Womack C,Clack G,Dixon JM
Sun Mar 01 00:00:00 EST 2009
Src inhibitors in early breast cancer: a methodology, feasibility and variability study.
Breast cancer research and treatment
Jones RJ,Young O,Renshaw L,Jacobs V,Fennell M,Marshall A,Green TP,Elvin P,Womack C,Clack G,Dixon JM
Sun Mar 01 00:00:00 EST 2009
Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.
BMC cancer
Sachdev S,Bu Y,Gelman IH
44-720G was used in western blot to review the functional consequences of interactions between focal adhesion kinase and Src are protein tyrosine kinases
Mon Jan 12 00:00:00 EST 2009
Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contraction.
American journal of physiology. Cell physiology
Rembold CM,Tejani AD,Ripley ML,Han S
44-720G was used in Western Blotting to show that some part of the sustained phase of swine carotid artery contraction may depend on stimulated actin polymerisation and/or a transition to a more solid rheology.
Sat Sep 01 00:00:00 EDT 2007
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST.
The Journal of biological chemistry
Lu TJ,Lai WY,Huang CY,Hsieh WJ,Yu JS,Hsieh YJ,Chang WT,Leu TH,Chang WC,Chuang WJ,Tang MJ,Chen TY,Lu TL,Lai MD
44-720G was used in western blot to report that MST3 inhibits cell migration
Fri Dec 15 00:00:00 EST 2006
p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV.
The Journal of biological chemistry
Sanders MA,Basson MD
44-720G was used in western blot to study the essential role for Caco-2 intestinal epithelial cell spreading and migration on collagen IV by p130cas but not paxillin
Fri Jun 24 00:00:00 EDT 2005
Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling.
The Journal of biological chemistry
Liu Y,Yerushalmi GM,Grigera PR,Parsons JT
Fri Mar 11 00:00:00 EST 2005
Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Grace EA,Busciglio J
Wed Jan 15 00:00:00 EST 2003
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.
The Journal of biological chemistry
Nakamura K,Yano H,Uchida H,Hashimoto S,Schaefer E,Sabe H
Fri Sep 01 00:00:00 EDT 2000
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.
The Journal of biological chemistry
Nakamura K,Yano H,Uchida H,Hashimoto S,Schaefer E,Sabe H
Fri Sep 01 00:00:00 EDT 2000
