AbboMax

Phospho-TGFBR1 (Ser187, Ser189, Ser191) Polyclonal Antibody

View all (22) TGFBR1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

620-900

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide derived from internal sequence (-TS*GS*GS*G-) with a phosphorylation sites at Serine 187, 189 and 191 of mouse TGFbeta receptor type-1
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

Positive control: MCF7

Cellular location: Membrane, Cytoplasm.

Target Information

TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ESK2; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; Transforming growth factor-beta receptor type I

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Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; AU017191; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TbetaR-I; TbetaRI; TGFBR1; TGFR-1

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UniProt ID: (Human) P36897, (Rat) P80204, (Mouse) Q64729

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Entrez Gene ID: (Human) 7046, (Rat) 29591, (Mouse) 21812

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Function(s)
protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I receptor signaling protein activity type II transforming growth factor beta receptor binding protein binding ATP binding growth factor binding SMAD binding metal ion binding transforming growth factor beta binding I-SMAD binding ubiquitin protein ligase binding protein complex binding protein heterodimerization activity nucleotide binding transmembrane receptor protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
activation of MAPKK activity skeletal system development angiogenesis in utero embryonic development kidney development blastocyst development epithelial to mesenchymal transition negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lens development in camera-type eye ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis proepicardium development regulation of transcription, DNA-templated protein phosphorylation apoptotic process cell cycle arrest signal transduction transforming growth factor beta receptor signaling pathway heart development positive regulation of cell proliferation germ cell migration male gonad development post-embryonic development anterior/posterior pattern specification regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation collagen fibril organization positive regulation of cell growth positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of chondrocyte differentiation activin receptor signaling pathway intracellular signal transduction wound healing endothelial cell activation extracellular structure organization regulation of protein binding endothelial cell migration positive regulation of transcription, DNA-templated thymus development neuron fate commitment embryonic cranial skeleton morphogenesis skeletal system morphogenesis mesenchymal cell differentiation artery morphogenesis cell motility positive regulation of cellular component movement positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of protein kinase B signaling parathyroid gland development palate development pharyngeal system development regulation of cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis coronary artery morphogenesis response to cholesterol cellular response to transforming growth factor beta stimulus positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway response to hypoxia transmembrane receptor protein serine/threonine kinase signaling pathway embryo implantation aging response to toxic substance regulation of gene expression positive regulation of gene expression response to organic cyclic compound lung development organ regeneration response to prostaglandin E regulation of growth negative regulation of apoptotic process response to estrogen negative regulation of endothelial cell differentiation protein autophosphorylation digestive tract development response to electrical stimulus embryo development phosphorylation cell differentiation
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