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Product Details
BS-3719R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human Talin around the phosphorylation site of Ser425.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: talin 2; Talin-1; Talin-2
Gene Aliases: 5730421P04Rik; AI507121; AI787438; AL118320; ILWEQ; KIAA0320; KIAA1027; mKIAA0320; RGD1565416; TLN; TLN1; TLN2
UniProt ID: (Human) Q9Y490, (Human) Q9Y4G6, (Mouse) P26039, (Mouse) Q71LX4
Entrez Gene ID: (Human) 7094, (Human) 83660, (Rat) 313494, (Mouse) 21894, (Mouse) 70549, (Rat) 315776
integrin binding
structural constituent of cytoskeleton
protein binding
vinculin binding
LIM domain binding
actin filament binding
cadherin binding involved in cell-cell adhesion
actin binding
structural molecule activity
molecular_function
insulin receptor binding
protein complex binding
non-motor actin binding protein
platelet degranulation
movement of cell or subcellular component
muscle contraction
cytoskeletal anchoring at plasma membrane
cell-cell junction assembly
cell-substrate junction assembly
viral process
cortical actin cytoskeleton organization
IRE1-mediated unfolded protein response
platelet aggregation
cell adhesion
biological_process
Performance Guarantee
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