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Invitrogen
Phospho-VANGL2 (Ser14, Ser17) Recombinant Rabbit Monoclonal Antibody (4C7Y1)
FIGURE: 1 / 1
Phospho-VANGL2 (Ser14, Ser17) Antibody (MA5-42957) in WB
Western blot analysis of Phospho-VANGL2 (Ser14, Ser17) in C6 cells. Samples were incubated with Phospho-VANGL2 (Ser14, Ser17) Monoclonal antibody (Product # MA5-42957) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. C6 cells were treated by wnt (100 ng/mL) for 30 minutes. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry mi... View More
Product Details
MA5-42957
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4C7Y1
Immunogen
A phospho specific peptide corresponding to residues surrounding S14/S17 of human VANGL2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2912098
Product Specific Information
Positive test controls include: HeLa. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.
Target Information
Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Loop-tail protein 1 homolog; loop-tail-associated protein; MGC119403; MGC119404; Strabismus 1; Van Gogh-like protein 2; vang; vang-like 2 (van gogh, Drosophila); Vang-like protein 2
Gene Aliases: KIAA1215; LPP1; LTAP; STB1; STBM; STBM1; VANGL2
UniProt ID: (Human) Q9ULK5
Entrez Gene ID: (Human) 57216
establishment of planar polarity
neural tube closure
hair follicle development
heart looping
membranous septum morphogenesis
muscular septum morphogenesis
planar cell polarity pathway involved in axis elongation
Rho protein signal transduction
anterior/posterior pattern specification
heparan sulfate proteoglycan biosynthetic process
convergent extension involved in neural plate elongation
regulation of Wnt signaling pathway
glomerulus development
regulation of actin cytoskeleton organization
somatic stem cell population maintenance
nonmotile primary cilium assembly
cell migration involved in kidney development
post-anal tail morphogenesis
dopaminergic neuron axon guidance
serotonergic neuron axon guidance
wound healing
positive regulation of JUN kinase activity
apical protein localization
establishment or maintenance of epithelial cell apical/basal polarity
somatic stem cell division
establishment of body hair planar orientation
digestive tract morphogenesis
convergent extension involved in axis elongation
inner ear receptor stereocilium organization
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
lateral sprouting involved in lung morphogenesis
kidney morphogenesis
planar cell polarity pathway involved in heart morphogenesis
cochlea morphogenesis
establishment of planar polarity involved in neural tube closure
planar cell polarity pathway involved in neural tube closure
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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